Clinical trials: Small Airways Disease
COPD, Smoking
Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD
Early changes associated with the development of smoking-induced diseases, e.g., COPD and lung cancer (the two commonest causes of death in U.S.) are often characterized by abnormal airway epithelial differentiation.
- Conditions
- COPD, Smoking, Lung Disorder
- Trial name
- NCT02341326
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
COPD, Small Airway Disease
The Prevalence of Small Airways Dysfunction In COPD Patients and The Impact on COPD Control
Chronic obstructive pulmonary disease (COPD) is a worldwide prevalent disease. During recent years, increasing attention has been directed to the importance of the contribution of small airways in respiratory diseases.
- Trial name
- NCT04384133
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Healthy, COPD
Closing Volume Interpretation and Bronchodilators Effect
The gold standard measures to evaluate small airways (SAW) "in vivo" is not well understood Two tests are today used to measure SAW but real results concordance is not clear These problems have a small evidence Data about real…
- Trial name
- NCT01437748
- Testing
- Indacaterol maleate, Tiotropium bromide
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Milan
Chronic Obstructive Pulmonary Disease, Lower Respiratory Disease
Small Airway Chronic Obstructive Disease Syndrome Following Exposure to WTC Dust
Many "Survivors" in the World Trade Center (WTC) clinical program have a clinical syndrome characterized by chronic obstruction in small airways and persistence of lower respiratory symptoms despite therapy.
- Trial name
- NCT03089515
- Testing
- Cardio-Pulmonary Exercise Testing (CPET)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Smoking, COPD
Integrative-omics of the Disordered COPD Small Airway Epithelium
We aim to use an integrated network systems approach to analyze certain existing small airway epithelium (SAE) omic data sets at the genetic, epigenetic (methylation), gene expression, microRNA and metabolomic levels, to develop…
- Trial name
- NCT02183818
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Asthma, Airway Hyperresponsiveness
Small Airways Disease in Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness (AHR)
The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.
- Trial name
- ABHR (NCT01549483)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Asthma
Small Airway Inflammation and Dysfunction in Different Asthma Phenotypes
Small airway inflammation and dysfunction will be measured in 40 children and 40 adults with asthma before and after 8 weeks of treatment with inhaled budesonide.
- Trial name
- NCT03718793
- Testing
- Peripheral exhaled nitric oxide
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Obesity
Expiratory Airflow Limitation in Subjects With Obesity
The purpose of this study is to investigate posture dependent small airway obstruction in subjects with obesity, and to study the capacity of FOT as a measurement tool for small airways obstruction.
- Trial name
- EFL (NCT00865293)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Cystic Fibrosis
Bronchial Inflammation of Small Airways in Patients With Cystic Fibrosis
In the planned study, 60 patients with mild cystic fibrosis (CF) with and without the involvement of small airways (small airway disease - SAD) are to be compared with a historical control group matched in age and gender.
- Trial name
- FRA-MUKO (NCT01479166)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Early Adult Lung Function, Small Airway Disease
Factors Affecting Early Adult Lung Function
Attainment of peak healthy lung function during the 18-26 yr window is a strong determinant of the rate of lung function decline during the later years of life.
- Conditions
- Early Adult Lung Function, Small Airway Disease, Metabolic Syndrome
- Trial name
- FEAL (NCT03187158)
- Testing
- Forced Oscillation Technique
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Council of Scientific and Industrial Research, India
Small Airways Diseases, Vaping
The Canadian Lung Outcomes in Users of Vaping Devices Study
Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient…
- Conditions
- Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
- Trial name
- CLOUD (NCT06819969)
- Where
- 8 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Lung Disease
Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease
To determine the utility and sensitivity of the lung clearance index (LCI) technique as a marker of small airways disease in adults with chronic lung conditions compared to healthy adults, adjusting for age, sex and smoking…
- Trial name
- NCT03241420
- Testing
- lung clearance index (LCI)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Asthma, Small Airway Disease
The Prevalence Of Small Airways Dysfunction In Asthma Patients And The Impact On The Asthma Control
Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden.
- Trial name
- NCT04375995
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Asthma
AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS)
Multinational, multicentre, non-pharmacological intervention, cross-sectional and longitudinal study.
- Trial name
- ATLANTIS (NCT02123667)
- Where
- 26 sites in United States, Brazil and 6 more
- Volunteers
- 872 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Apnea, Airway Obstruction, Nasal
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least.
- Conditions
- Apnea, Airway Obstruction, Nasal, Mandible Small, Maxillary Hypoplasia
- Trial name
- NCT04190953
- Testing
- Twin block then Hyrax, Hyrax then Twin block
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
COPD, Asthma
Imaging Lung Function Using Oxygen Enhanced MRI
The goal of this study is to perform a pilot study to evaluate the utilization of oxygen as an inhaled contrast agent to image the airway spaces in normal and diseased human lungs to allow an effect size estimate to power future…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01731015
- Testing
- Medical Grade Oxygen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
COPD, Asthma
Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen
An open label study in 40-60 subjects with diagnosed lung airway disease and in 10-20 normal controls. Each subject will receive PFP as a contrast agent to visualize the airway and alveolar spaces in their lungs using magnetic…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01710449
- Testing
- perfluorinated gas/oxygen mixture
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease (COPD) experience breathing difficulties because the airways deep in their lungs become narrowed. COPD patients use inhaler drugs to provide relief from breathlessness.
- Conditions
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HEALTHY SUBJECTS
- Trial name
- NCT01721291
- Testing
- SALBUTAMOL
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Imperial College London