Clinical trials: Small Bowel Bacterial Overgrowth Syndrome
Decompensated Cirrhosis, Small Bowel Bacterial Overgrowth Syndrome
Primary Prophylaxis for Spontaneous Bacterial Peritonitis
Patient with liver cirrhosis commonly have co-existing small bowel bacterial overgrowth (SIBO) yet may be asymptomatic. It is unclear as to the value of treating SIBO in asymptomatic individuals.
- Trial name
- SIBOC (NCT04775329)
- Testing
- Rifaximin
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Changi General Hospital
Irritable Bowel Syndrome
EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth
Primary objective: to assess the efficacy of Bacillus clausii versus metronidazole in the eradication of the small intestinal bacterial overgrowth, 30 days after the end of treatment.
- Trial name
- NCT00331994
- Testing
- Bacillus clausii, Metronidazole
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Sanofi
Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Combined Lactulose H2-breath Test With Abdominal Imaging
Hydrogen (H₂) breath tests serve several purposes. (i) detect malabsorption of carbohydrates such as lactose and fructose, (ii) measurement of oro-caecal transit time (iii) associate hydrogen production with the onset of…
- Conditions
- Food Intolerance Syndromes, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Breath Tests
- Trial name
- NCT07145580
- Where
- Switzerland
- Volunteers
- 510 people
- Sponsor
- Klinik Arlesheim
Celiac Disease
Rifaximin for the Treatment of Persistent Symptoms in Patients With Celiac Disease
Celiac disease is a condition in which the small intestine is damaged by gluten, the storage protein of wheat and similar proteins in barley and rye.
- Trial name
- NCT01137955
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
Effect of a Probiotic Formula on Reducing SIBO in IBS Patients
This randomized study evaluates the effectiveness of the a probiotic formula, compared with the antibiotic rifaximin, in the treatment of Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome (IBS) patients.
- Trial name
- NCT04316806
- Testing
- Probiotic, Rifaximin
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- AB Biotics, SA
Functional Dyspepsia, Small Intestinal Bacterial Overgrowth
Small Intestinal Bacterial Overgrowth: A Prospective Registry
The purpose of this study is to investigate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients who will be undergoing an enteroscopy as an outpatient procedure with symptoms of functional dyspepsia.
- Trial name
- SIBO (NCT01822470)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Bacterial Overgrowth Syndrome Small Bowel, Heart Failure with Preserved Ejection Fraction
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
Single-center, double-blind, randomized, controlled intervention study of the effect of correction of bacterial overgrowth syndrome in the small intestine (SIBO) on cardiac function in patients with heart failure with preserved…
- Trial name
- SIBO-HFpEF (NCT06652087)
- Testing
- Rifaximin, Standard HFpEF treatment
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Irritable Bowel Syndrome
Rifaximin for the Treatment of Irritable Bowel Syndrome
We have recently shown that the majority of patients with irritable bowel syndrome (IBS) have an abnormal lactulose breath test to suggest the presence of bacterial overgrowth of the small intestine.
- Trial name
- NCT00259155
- Testing
- Rifaximin
- Volunteers
- 92 people
- Sponsor
- Cedars-Sinai Medical Center
Diarrhea Predominant Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
Use of SBI in IBS Subjects Following a Successful Treatment of Small Intestinal Bacterial Overgrowth
The primary objective of this study is to determine whether giving SBI as a medical food starting with maintenance of health in the management of chronic loose and frequent stools in IBS-D subjects with SIBO after successful…
- Trial name
- NCT02251483
- Testing
- Serum-derived bovine immunoglobulin protein isolate (SBI)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Cedars-Sinai Medical Center
Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Comparison of the Efficacy of Saccharomyces Boulardii and Rifaximin in the Treatment of Small Intestinal Bacterial Overgrowth
This multicenter randomized controlled study aims to systematically evaluate the efficacy and safety of Saccharomyces boulardii sachets versus rifaximin in the treatment of small intestinal bacterial overgrowth (SIBO), with a…
- Trial name
- NCT07815548
- Testing
- Saccharomyces boulardii sachets, Rifaximin (Xifaxan)
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Shandong University
Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Evaluation Of Artemisia Annua For Small Intestinal Bacterial Overgrowth
Small intestinal bacterial overgrowth (SIBO) can cause symptoms like bloating, stomach pain, and changes in bowel movements, significantly affecting quality of life.
- Trial name
- HERBA-SIBO (NCT06721884)
- Testing
- Artemisia Annua Leaf
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National University of Natural Medicine
SEPSIS, MALNUTRITION, CHILD
Pancreatic Enzymes and Bile Acids in Acutely Ill Severely Malnourished Children
Children with severe malnutrition who are sick and admitted to hospitals have high mortality, usually because of infection. Malnourished children have more potentially harmful bacteria in their upper intestines than…
- Trial name
- PB-SAM (NCT04542473)
- Testing
- Pancreatic Enzyme, Ursodeoxycholic acid
- Where
- 4 sites in Bangladesh, Kenya and 2 more
- Volunteers
- 400 people
- Sponsor
- University of Oxford
Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
Gulf War Digestive Health Study
The purposes of this study are to estimate the burden of disease due to chronic gastrointestinal illness in PG veterans, to evaluate whether Small Bowel Bacterial Overgrowth (SBBO) is associated with chronic diarrhea in PG…
- Trial name
- NCT00680836
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- US Department of Veterans Affairs
Malabsorption Syndromes
Validation of Breath Tests in Diagnosing Small Bowel Bacterial Overgrowth
Normally the gastrointestinal tract is only sparsely colonized with bacteria. The normal flora of the duodenal or jejunal aspirate contains no more than 10^5 bacteria per milliliter.
- Trial name
- BTO (NCT00872092)
- Testing
- Stable-isotope labeled lactose ureide breath test
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bonn
Small Intestinal Bacterial Overgrowth, SIBO
The Safety And Efficacy Of A Probiotic Intervention On Lactulose Hydrogen Breath Test-Positive Patients And Related Gastrointestinal Symptoms
The goal of this study is to test the effect of a probiotic formulation on gastrointestinal symptoms, gut and small intestine microbiota in participants suffering from small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT06317441
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Nimble Science Ltd.
Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome
The goal of this clinical trial is to learn if an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS).
- Trial name
- NCT07768267
- Testing
- Biocidin REMOVE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Cancer
The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms"
The aim of the study is to identify how often gastrointestinal problems interfere with quality of life as a result of treatment for cancer with chemotherapy.
- Trial name
- FOCCUS (NCT02121626)
- Where
- United Kingdom
- Volunteers
- 248 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
The Efficacy of Probiotics as an Adjunct to Treatment of SIBO With Rifaximin
The goal of this clinical trial is to test the effectiveness of probiotic bacterial supplements as an additional therapeutic modality in patients with small intestine bacterial overgrowth who receive oral antibiotic treatment…
- Conditions
- Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth, SIBO
- Trial name
- NCT06223685
- Testing
- Rifaximin (Xifaxan) 1200mg/day, Probiotic, XIFAXAN® (Rifaximin) 1600mg/day
- Where
- Poland
- Volunteers
- 129 people
- Sponsor
- Pomeranian Medical University Szczecin
Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome
SIBO, Immune Activation, and FGIDs in Children
PURPOSE: This study will evaluate the relationships between small intestinal bacterial overgrowth (SIBO), immune activation, inflammation, and symptoms in pediatric abdominal pain-related functional gastrointestinal disorders…
- Conditions
- Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome, Functional Dyspepsia, Functional Abdominal Pain
- Trial name
- SIBO (NCT02872961)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The University of Texas Health Science Center, Houston
Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Small Bowel Bacterial Overgrowth Syndrome (SBBOS)
Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing
The objective of this study is to compare the efficacy of prokinetics versus antibiotics versus a combination of antibiotics plus prokinetics in the eradication of Small-Intestinal Bacterial Over-Growth Syndrome (SIBO) in those…
- Trial name
- SIBO (NCT01324895)
- Where
- United States
- Volunteers
- 944 people
- Sponsor
- University of Florida