Clinical trials: Small Fiber Neuropathy
Small Fiber Neuropathy
Detection of Small Fiber Neuropathy Using Skin Properties
Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating.
- Trial name
- NCT04759443
- Testing
- Image processing of skin
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Neuropathic Pain
Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)
This research is being done to study a possible treatment for refractory pain due to small fiber neuropathy (SFN). ST-503 is intended to deliver a modified copy of the gene which will ideally repress Nav1.7 tissue-related pain…
- Trial name
- NCT06980948
- Testing
- ST-503
- Where
- 11 sites in United States
- Volunteers
- 27 people
- Sponsor
- Sangamo Therapeutics
Primary Sjögren Syndrome, Small Fiber Neuropathy
Medico-economic and Quality of Life Impact of Sjogren-associated Small Fiber Neuropathy
BACKGROUND Sjögren's syndrome is an autoimmune disease whose prevalence is estimated between 200 and 500 patients per 100,000 persons in France (120 to 500,000 patients).
- Conditions
- Primary Sjögren Syndrome, Small Fiber Neuropathy, Quality of Life, Medico-economic Impact
- Trial name
- SFINESS-QoLEco (NCT03509064)
- Testing
- Collection sheet
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Painful Peripheral Diabetic Neuropathy
Nociceptive Pain Fiber Response
This study is designed to evaluate the effectiveness of the Provant Therapy System in improving localized nerve growth and skin perfusion in subjects with painful peripheral diabetic neuropathy of the foot.
- Trial name
- NCT02696070
- Testing
- Provant Therapy System
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Small Fiber Neuropathy, Diabetic Neuropathies
Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study
The aim of work is to study the clinical, electrodiagnostic and neurosonographic characteristics of diabetic patients with small fiber neuropathy in the Egyptian population, and to evaluate both the diagnostic and the prognostic…
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Autonomic Neuropathy, Diabetic Peripheral Neuropathy
- Trial name
- NCT05993871
- Testing
- Clinical Evaluation/Questionnaires, Nerve Conduction Study, Small fiber electrodiagnostic tests
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tanta University
Chemotherapy-induced Peripheral Neuropathy
Diagnostic of Chemotherapy Induced Neuropathy in Children
The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific…
- Trial name
- SUDOPED (NCT04262778)
- Testing
- electrochemical skin conductance measurement
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Small Fiber Neuropathy
Spinal Cord Stimulation in Small Fibre Neuropathy
Small fibre neuropathy (SFN) is a disorder in which selectively thinly myelinated and unmyelinated nerve fibres are involved. SFN can cause severe and chronic symptoms such as burning pain in the extremities in combination with…
- Trial name
- SFN-SCS (NCT02905396)
- Testing
- Spinal cord stimulation
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Small Fiber Neuropathy
Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy
Small fiber neuropathy (SFN) is the most common cause of neuropathic pain in peripheral neuropathies, with a prevalence of at least 53/100.000.
- Trial name
- IVIg-SFN (NCT02637700)
- Testing
- Intravenous Immunoglobulin
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Small Fiber Neuropathy, Diabetes Mellitus
Efficacy and Safety Study of BIIB074 in Participants With Small Fiber Neuropathy
The primary objective of this study is to evaluate the efficacy of BIIB074 in treating pain experienced by participants with confirmed small fiber neuropathy (SFN) that is idiopathic or associated with diabetes mellitus.
- Trial name
- NCT03339336
- Testing
- BIIB074
- Where
- 97 sites in Bulgaria, Canada and 12 more
- Volunteers
- 265 people
- Sponsor
- Biogen
Small Fiber Neuropathy
fMRI-study in Patients With Small Fiber Neuropathy
Small fiber neuropathy (SFN) is a form of peripheral neuropathy, which is characterized by neuropathic pain and autonomic dysfunction.
- Trial name
- NCT03889080
- Testing
- functional MRI
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Academisch Ziekenhuis Maastricht
Fibromyalgia
The Effect of Transcutaneous Posterior Tibial Nerve Stimulation in Patients With Fibromyalgia
This study aimed to investigate the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing pain, improving quality of life, and decreasing disease severity in patients with fibromyalgia.
- Trial name
- NCT05937711
- Testing
- Transcutaneous Posterior Tibial Nerve Stimulation + Duloxetine 30 MG, Duloxetine 30 MG
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ilker Fatih Sari
Systemic Autoimmune Pathologies, Unexplained Pain Syndrome
Detection of Small Fiber Neuropathies by the Non-invasive SUDOSCAN Method During Chronic Autoimmune Pathologies and / or Unexplained Pain Syndromes
Very few studies have evaluated the prevalence of small fiber neuropathy (SFN) during pathologies that may be responsible for small fibers damage.
- Trial name
- SUDOCU (NCT04927832)
- Testing
- SUDOSCAN and EMG (electromyogram)
- Where
- France
- Volunteers
- 139 people
- Sponsor
- Hôpital Européen Marseille
Small-Fiber Neuropathy, Chronic Kidney Disease
Small-fiber Neuropathy in Chronic Kidney Disease
Neurological dysfunction is a common complication of late stage chronic kidney disease (CKD) and peripheral nerve system is often involved in such complication.
- Trial name
- NCT01078857
- Testing
- Skin biopsy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Small Fiber Neuropathy
Establishing Normative Values for Thermal Detection and Pain Threshold Established by the Psi Method
The study aims to compare different methods to assess thermal detection ability in diabetic patients, as a way to monitor and diagnose neurological complications of diabetes mellitus.
- Trial name
- NCT04611048
- Testing
- Thermal QST (CDT, WDT, CPT, HPT) with the method of limits, Thermal QST (cold and warm detection, heat pain) with the psi method, Neurological examination
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Small Fiber Neuropathy, Diabetic Neuropathies
Skin Biopsy in the Diagnosis of Small Fiber Neuropathy in Chinese Patients With Diabetes
To detect small fiber neuropathy in patients with possible or established diabetic peripheral neuropathy (DPN) by skin biopsy and explore clinical characteristics and pathological features in Chinese patients with diabetes.
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Diabetes Mellitus
- Trial name
- NCT04071535
- Testing
- sudoscan、nerve conduction tests
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy
IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 Antibodies
This study will enroll patients with small fiber neuropathy (SFN). The study will look at an intravenous immunoglobulin (IVIG) called Panzyga.
- Conditions
- Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy, Inflammatory Polyneuropathy, Immune-Mediated Neuropathy
- Trial name
- NCT04153422
- Testing
- Panzyga IVIG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Chronic Pain Syndrome
Fibromyalgia and Small Fiber Neuropathy
The primary objective of this study will be to assess the proportion of fibromyalgia patients with diffuse small-fiber neuropathy (i.e.
- Trial name
- FIBRO-NEP (NCT06527183)
- Testing
- Skin punch biopsy to demonstrate small fiber neuropathy
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital Ambroise Paré Paris
Neuropathy, Small Fiber, Diabete Mellitus
Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy
Tirzepatide is a dual agonist of GLP-1 Receptor and the GIP receptor, producing substantial improvement in glycaemic control, weight reduction and insulin sensitivity.
- Trial name
- T-DPN (NCT07706088)
- Testing
- Tirzepatide 2.5mg weekly, all standard of care to diabetic patient besides tirzepatide
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh