Clinical trials: Smoker, open to volunteers
Lung Carcinoma
Educating Smokers About Lung Cancer Screening Using Tobacco Quitlines
This implementation study will examine the best ways to refer heavy smokers to information about lung cancer screening.
- Trial name
- NCT04595422
- Testing
- Educational Intervention, Questionnaire Administration, Survey Administration
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
COPD, Lung Cancer (NSCLC)
Tumors and Respiratory System Diseases Due to Air Pollution: New Biomarkers of Exposure and Effects
This study aims to examine the exposure to atmospheric pollutants in a group of non-smoking patients suffering from lung cancer, chronic obstructive pulmonary disease (COPD), and leukemia.
- Conditions
- COPD, Lung Cancer (NSCLC), Leukemia
- Trial name
- RECAP (NCT06800586)
- Where
- 3 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Smoking
Comparison of the Effects of Different Chest Techniques on University Students With Smoking Addiction
Smoking is a significant risk factor for heart, lung, and respiratory system diseases, and is particularly prevalent among young people and university students.
- Trial name
- NCT07488741
- Testing
- Chest PNF Techniques Group, Chest Mobility Exercises Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Smoking
An Internet-based Dialectical Behaviour Therapy-informed Skills Training for Promoting Smoking Cessation and Improving Psychological Distress of Adult Smokers.
1. To determine the feasibility, acceptability, and preliminary effects of an internet-based DBT-ST for promoting smoking abstinence/reduction and improving psychological distress/emotional regulation in adult smokers 2.
- Trial name
- NCT06575673
- Testing
- Internet-based dialectical behaviour therapy-informed skills training, Monthly health education
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Heavy Smokers, Lung Cancer Screening
Akershus Cardiac Examination (ACE) 5 Study
Individuals with extensive smoking history have 2- to 3-fold increased risk of dying prematurely compared to age- and gender-matched peers.
- Conditions
- Heavy Smokers, Lung Cancer Screening, Cardiovascular Risk Profile, Cardiovascular Disease Prevention
- Trial name
- ACE5 (NCT07301489)
- Testing
- Lung Cancer Screening Plus Program, Standard of Care
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Smoking, Smoking Behaviors
Take A Break - Rural
The study team proposes a multi-level trial to test 1) novel implementation programs in rural counties designed to increase access to 2) recent advances in tobacco control services for people who are not-yet-ready-to-quit…
- Conditions
- Smoking, Smoking Behaviors, Smoking Cessation
- Trial name
- TABR (NCT05790486)
- Testing
- Take a Break plus Nicotine replacement therapy (NRT) Sampling, The Comparison, Community Paramedicine Standard Plus Enhanced Implementation Program
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cigarette Smoker, Current Smoker
Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer
This randomized clinical trial studies the Beating Lung Cancer in Ohio protocol in improving survival in patients with stage IV non-small cell lung cancer.
- Conditions
- Cigarette Smoker, Current Smoker, Lung Adenocarcinoma, Squamous Cell Lung Carcinoma
- Trial name
- BLCIO (NCT03199651)
- Testing
- Best Practice, Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 3,584 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use
Impact of Semaglutide on Tobacco Use and Related Health Behaviors
This pilot randomized trial will assess the impact of 12 weeks of semaglutide administration (vs placebo) on changes in: (i) tobacco use and related factors (nicotine craving, withdrawal, motivation to quit, etc.) and (ii)…
- Trial name
- ONSET (NCT06986993)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Smoking Electronic Cigarettes (Vaping), With Moderate and High Dependence for Nicotine
EFFECT OF WIM HOF BREATHING EXERCISE ON VENTILATORY FUNCTIONS IN SMOKERS
Cigarette smoking is the most common form of tobacco use worldwide, but other tobacco products, such as e-cigarettes, cigars, cigarillos, roll-your-own, pipes, and various smokeless tobacco products are also damaging.
- Trial name
- NCT07153640
- Testing
- 1 ) Wim Hof Breathing Exercise, 2) Aerobic exercises
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October 6 University
Thromboangiitis Obliterans (Buerger's Disease)
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the…
- Trial name
- NCT07215923
- Testing
- ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Antidote Therapeutics, Inc
Lazertinib
A Randomized Phase II Study of LAZE rtiNib Alone Versus Lazertinib Plus bevaCizumab for NSCLC With EGFR + & Smoker
Using gefitinib or Osimertinib, an EGFR tyrosine kinase inhibitor (TKI), in patients with active mutations in epithelial cell growth factor receptors (EGFR), 70% response rate (CR+PR) and 90% disease control rate (CR+PR+SD)…
- Trial name
- NCT06156527
- Testing
- Lazertinib, Bevacizumab Injectable Product
- Where
- 5 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- National Cancer Center, Korea
Tobacco Use Cessation
VergeRx for Smokers Not Ready to Quit
This study uses a factorial optimization experiment to identify which treatment components help adults who smoke and are not ready to quit in the next 30 days (smokers not ready to quit, or SNRTQ) achieve smoking cessation.
- Trial name
- NCT07693660
- Testing
- VergeRx, SmokefreeTXT, NRT Lozenge (Combination)
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Preserved Ratio Impaired Spirometry (PRISM)
Role of Exercise in PRISm and Subsequent Development of COPD
Preserved Ratio Impaired Spirometry (PRISm) describes individual with spirometry findings of forced expiratory volume (FEV1) and forced vital capacity (FVC) ratio greater than 0.7 but with the FEV1 less than 80% predicted.
- Trial name
- NCT07387432
- Testing
- Exercise with telehealth group, Exercise group, No exercise group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Smoking, Pain
Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
PASS2 aims to expand upon the recently completed study (PASS intervention), which tested the telephone delivery of a cognitive behavioral intervention (CBI).
- Conditions
- Smoking, Pain, Smoking Cessation
- Trial name
- PASS2 (NCT06442514)
- Testing
- PASS2, Treatment as Usual
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
A Culturally Tailored Smartphone Application for African American Smokers
The overall objectives of this research proposal, are to (a) create a smartphone application for smoking cessation (i.e., HealthyCells), which will be achieved by integrating two pre-existing evidence-based smartphone…
- Trial name
- HC (NCT05188287)
- Testing
- HealthyCells
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Ostracism
Experiment Among Smokers in Which Two Variables Are Manipulated: Ostracism and Concealability
The goal of this experimental study is to learn about the effects of ostracism and concealment among adult smokers. The main aims are: 1. Determine the causal consequences of gendered stigmatization.
- Trial name
- NCT06462950
- Testing
- Do men and women differ in their reactions to the experimental conditions.
- Volunteers
- 340 people
- Sponsor
- Dickinson College
Periodontal Disease
Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis
The aim of this study is to evaluate the effects of adjunctive synbiotic supplementation combined with non-surgical periodontal therapy in smokers with periodontitis.
- Trial name
- NCT07672379
- Testing
- Synbiotic supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Biruni University
Healthy, Healthy Smoker
Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With Chronic Obstructive Pulmonary Disease
This is a 4-part, randomised, double-blind, placebo-controlled, first in human study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of inhaled RB042.
- Conditions
- Healthy, Healthy Smoker, COPD (Chronic Obstructive Pulmonary Disease), COPD
- Trial name
- NCT07285122
- Testing
- RB042
- Where
- Australia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Atisama Therapeutics
Smoking (Tobacco) Addiction
Impact of Exercise Associated With Cognitive-behavioral Therapy in Smokers
Smoking remains one of the leading causes of global morbidity and mortality, responsible for more than 8 million deaths annually, according to data from the World Health Organization.
- Trial name
- NCT07186049
- Testing
- Thesis Sessions, General Health Guidelines, Thesis and Exercises
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Agnaldo José Lopes
Superoxide Dismutase, Acupuncture
The Effects of Manual Acupuncture on Superoxide Dismutase Enzyme Activity and Questionnaire of Smoking Urges-Brief Scores in Active Smokers: A Randomized Controlled Trial
The goal of this randomized, double-blind clinical trial is to evaluate the effects of a single session of manual acupuncture on superoxide dismutase (SOD) enzyme activity and smoking cravings in active smokers aged 21-40 years.
- Trial name
- NCT07895550
- Testing
- Acupuncture
- Where
- Indonesia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia