Clinical trials: Smokers
Healthy, Healthy Smoker
Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With Chronic Obstructive Pulmonary Disease
This is a 4-part, randomised, double-blind, placebo-controlled, first in human study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of inhaled RB042.
- Conditions
- Healthy, Healthy Smoker, COPD (Chronic Obstructive Pulmonary Disease), COPD
- Trial name
- NCT07285122
- Testing
- RB042
- Where
- Australia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Atisama Therapeutics
Periodontal Disease
Evaluation of Photodynamic Therapy as an Adjunct to Non-surgical Treatment in Periodontitis in Smokers vs. Non-smokers
Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant.
- Trial name
- NCT07697963
- Testing
- Photodynamic therapy (PDT)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pristina
Cigarette Smoking
Contingency Management for Smoking Abstinence With Adolescent Smokers
The primary objective of this research is to evaluate the effectiveness of this type of smoking cessation program by comparing a treatment group with a control group.
- Trial name
- CM (NCT01056588)
- Testing
- CO-Contingent, Control condition
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Tobacco Use Disorder
Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers
This randomized phase II trial studies the effects of aspirin and zileuton on genes related to tobacco use in current smokers. Aspirin and zileuton may interfere with genes related to tobacco use and may be useful in preventing…
- Trial name
- NCT02348203
- Testing
- Aspirin, Laboratory Biomarker Analysis, Zileuton
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Tobacco Use Cessation, Tobacco Use Disorder
Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1
Schizophrenic individuals are typically nicotine dependent smokers who find it difficult to quit smoking. The purpose of this study is to determine the effectiveness of bupropion SR (commonly known as Zyban) in combination with a…
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Schizophrenia
- Trial name
- NCT00124683
- Testing
- Bupropion, nicotine transdermal patch
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoker
Methods Project 4: Clinical Trial
Cigarette smokers who are eligible will enter a Camel Snus sampling phase. Smokers interested in continuing with the study after the sampling phase will undergo a 2 week baseline assessment phase and will then be randomized to…
- Trial name
- NCT01867242
- Testing
- Cigarettes, Snus
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Nicotine Dependence
Testing Financial Incentive Interventions in Dyadic-Smoker Couples
The proposed study investigates the feasibility and efficacy of FITs in dual-smoker couples [DSCs]. The core design is a three-group mixed repeated measures design, in which participants are randomized into one of three…
- Trial name
- NCT04832360
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Current Smoker, Tobacco Smoking
Project MARS: Mobile-Assistance for Regulating Smoking
This study aims to investigate approaches to capitalize on states of vulnerability and receptivity to deliver real-time self-regulation prompts among smokers.
- Trial name
- MARS (NCT04376489)
- Testing
- Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants not experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are not available)
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Utah
Smoking Cessation
Mobile Cessation Support for Latino Smokers
The primary aim of this study is to examine the efficacy of Decídetexto, an innovative mobile smoking cessation intervention that incorporates two elements: 1) a tablet-based e-Health platform that collects personal…
- Trial name
- NCT03586596
- Testing
- The Decídetext program, Standard Care Control
- Where
- 3 sites in United States
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Tobacco Use Cessation, Cancer Prevention
Project Impact 2: A Culturally Tailored Smoking Cessation Intervention for Latino Smokers
The goal of this research study is to learn how 3 different kinds of counseling treatments may help individuals to quit smoking.
- Trial name
- NCT02596711
- Testing
- Nicotine Patch, Questionnaires, Carbon Monoxide (CO) Test
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Nicotine Dependence, Cigarettes
Penn State TXT2STAYQUIT Study- a Texting Study to Help Hospitalized Smokers Stay Quit
This study aims to pilot a method of collecting the post-discharge follow-up data required by the Joint Commission Tobacco Measure Set, using text messages sent to and received from patients' cellular-telephones.
- Trial name
- NCT02986711
- Testing
- Motivational Text Messages, Control
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Influenza, Human, Smoking
Effects of Tobacco Products on Live Attenuated Influenza Virus (LAIV) Infections in Human Volunteers
Chronic exposure to (cigarette smoke) CS causes biological changes, including airway remodeling and changes in baseline gene expression profiles at the level of the epithelium.
- Conditions
- Influenza, Human, Smoking, Respiratory Tract Infections, Habits
- Trial name
- NCT02019745
- Testing
- LAIV
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Smoking, Tobacco Smoking
Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
This was a randomized, controlled, open-label, 4 parallel arm study with a stratified randomization by sex (a quota for each sex [females and males] of at least 40% overall).
- Conditions
- Smoking, Tobacco Smoking, Tobacco Use
- Trial name
- NCT05599451
- Testing
- THS Blade device, THS Induction Mono device, THS Induction Mid device
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cessation
Mixed and Match vs One-size-fits-all
Most existing smoking cessation services are based on '5A's' and '5R's' models which are recognized by the World Health Organization as a standardized tool for smoking cessation.
- Trial name
- NCT05297370
- Testing
- Mixed and match Intervention, Control
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy, Periodontitis
Effect of Non-Surgical Periodontal Treatment on Biomarker Levels
Periodontitis is a destructive disease that follows untreated gingivitis and is characterized by gingival inflammation, clinical attachment loss, alveolar bone loss and periodontal pocket formation, increased tooth mobility and…
- Trial name
- NCT06178081
- Testing
- Periodontal Healthy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biruni University
Smoking, Tobacco, Smoking
GeoScan and Remote Geo Smoking Study: Neural and Behavioral Correlates of Smokers' Exposure to Retail Environments
The purpose of the study is to learn more about the relationships between the brain, behavior, and natural daily exposure to particular environments, including the places where smokers regularly spend time and specific retail…
- Conditions
- Smoking, Tobacco, Smoking, Smoking, Cigarette
- Trial name
- NCT04279483
- Testing
- Tobacco retailer, Non-tobacco retailer
- Where
- United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Waterpipe Smoking
Understanding the Effect of Flavor on Hookah Smoking Experience
This project addresses the need for evidence about the effect of flavoring manipulation on waterpipe smokers' satisfaction, dependence, harm perception, and toxicants exposure.
- Trial name
- NCT03589599
- Testing
- Flavored tobacco, Non-flavored tobacco
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Florida International University
Mental Disorders
A Study to Examine the Pharmacodynamic Effects of GSK1034702 on Neurophysiological Biomarkers of Cognition in Nicotine Abstained Otherwise Healthy Smokers
This will be a double blind, randomised, placebo controlled, cross over study in which up to 20 otherwise healthy male nicotine abstinent smokers will be tested following 3 acute treatment conditions (placebo, 4 and 8mg of…
- Trial name
- MAA113746 (NCT01371799)
- Testing
- Drug
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smokers
Acute IMT Intensity Effects in Male Smokers
Acute IMT Intensity Effects in Male Smokers
- Trial name
- NCT07200895
- Testing
- Inspiratory Muscle Training (30% MIP), Inspiratory Muscle Training (60% MIP)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- FATMA DİLARA AKAR ÇAMYAR
Smoking
European Exposure Study
The current study was designed to determine the exposure of adult smokers and non-smokers to cigarette smoke constituents through evaluation of selected biomarkers of exposure.
- Trial name
- NCT01237912
- Where
- United Kingdom
- Volunteers
- 1,667 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.