Clinical trials: Smoking ( Cigarette)
Cardiovascular Diseases, Smoking
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
The purpose of this study is to demonstrate improvement in flow mediated dilation (FMD), a functional endpoint associated with the progression of atherosclerosis, when switching from cigarettes to the Tobacco Heating System (THS)…
- Conditions
- Cardiovascular Diseases, Smoking, Tobacco Use, Peripheral Arterial Disease
- Trial name
- NCT05566678
- Testing
- Cigarette, THS, Smoking Abstinence
- Sponsor
- Philip Morris Products S.A.
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Electronic Cigarettes vs Combustible Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three electronic cigarettes versus…
- Trial name
- NCT02269514
- Testing
- Own Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Smokers
Study to Evaluate the Efficacy, Safety, Tolerability and Immunogenicity of 100µg NIC002 Vaccine in Cigarette Smokers Who Are Motivated to Quit Smoking.
This study is designed to determine the efficacy of high nicotine-specific antibody titers in smoking cessation.
- Trial name
- NCT00736047
- Testing
- NIC002
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Novartis
Second Hand Tobacco Smoke
Study to Evaluate Constituents in Exhaled Breath and Room Air From Use of E-vapor Products and Conventional Cigarettes
An open-label, single center, three-arm observational study to examine emissions from e-cigarettes versus conventional cigarettes under three environmental settings of typical residential, office and hospitality facilities.
- Trial name
- NCT03605641
- Testing
- JUUL, VUSE Solo, Conventional Cigarette
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking
User Acceptability of a Nicotine Lactate Delivery System (P3L)
This study will provide an initial assessment of the acceptability of the Nicotine Lactate Delivery System (P3L) after ad libitum use and the ability of combustible cigarette (CC) smokers to use P3L to maintain their customary…
- Trial name
- NCT02643693
- Testing
- P3L, VUSE, CC
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Addiction Nicotine
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction.
- Trial name
- CONQUER (NCT07322432)
- Testing
- VapeAway filter system
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VapeAway
Drug Drug Interaction (DDI)
Drug-Drug Interaction (DDI) Study for TD-9855
This study is designed to assess the effect of fluvoxamine, itraconazole and smoking on the PK disposition of multiple doses TD-9855 in healthy male subjects.
- Trial name
- NCT03432793
- Testing
- TD-9855, Fluvoxamine, Itraconazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Smoking
Exploratory THS 2.1 Nicotine Pharmacokinetics and Safety Study
The main goal of this exploratory study is to evaluate the pharmacokinetic profile of nicotine for the candidate modified risk tobacco product THS 2.1 and for conventional cigarettes (CC).
- Trial name
- NCT01780688
- Testing
- Conventional cigarettes (CC), THS 2.1
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
CSD170302: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes
To determine the rate and amount of nicotine uptake with 10-minute ad libitum use of four different marketed electronic cigarettes.
- Trial name
- NCT03233997
- Testing
- FT21018, FT21033, FT21034
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three menthol electronic cigarettes…
- Trial name
- NCT02664012
- Testing
- Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Smoking, Tobacco Smoking
Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
This was a randomized, controlled, open-label, 4 parallel arm study with a stratified randomization by sex (a quota for each sex [females and males] of at least 40% overall).
- Conditions
- Smoking, Tobacco Smoking, Tobacco Use
- Trial name
- NCT05599451
- Testing
- THS Blade device, THS Induction Mono device, THS Induction Mid device
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Healthy
Determination of Biomarkers of Exposure and Biomarkers of Potential Harm in Asian Adult Cigarette Smokers
The purpose of this study is to determine biomarkers of exposure to Harmful and Potentially Harmful Constituents (HPHCs) in Cigarette Smoke and cardiovascular-related biomarkers in smokers and non smokers.
- Trial name
- NCT02103751
- Where
- Japan
- Volunteers
- 1,069 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Behaviors, Smoking ( Cigarette)
A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products
This will be a randomized, open-label, 8-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking Behaviors, Smoking ( Cigarette), Tobacco Use
- Trial name
- NCT07739797
- Testing
- Golden Tobacco Chill 5% (4) 6.5W, Glacier Menthol 5% (4) 6.5W, Fresh Mint 5% (4) 6.5W
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation
The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette
This three-group randomized double-blind placebo-controlled trial (N=180) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CCs) to an e-cigarette.
- Trial name
- NCT05205811
- Testing
- Bupropion, Zonisamide, E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking
European Exposure Study
The current study was designed to determine the exposure of adult smokers and non-smokers to cigarette smoke constituents through evaluation of selected biomarkers of exposure.
- Trial name
- NCT01237912
- Where
- United Kingdom
- Volunteers
- 1,667 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
CSD170303: Study to Assess Nicotine Uptake in Smokers From Electronic Cigarettes
To determine the rate and amount of nicotine uptake with 10-minute ad libitum use of four different marketed electronic cigarettes.
- Trial name
- NCT03234010
- Testing
- FT21092, FT21093, FT21096
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation
Study of a Smartphone-Based Switch Program
Prospective, open label, single center clinical study enrolling up to 120 participants to evaluate the Pivot cigarette smoking cessation program in adult smokers, previously unable to quit, who also use other smoke-free nicotine…
- Trial name
- NCT06544772
- Testing
- Pivot cigarette smoking cessation program
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Pivot Health Technologies Inc.
Tobacco Use, Smoking
CSD231005 Nicotine Pouch Biomarkers of Exposure
This will be a multi center open label, randomized, controlled, switching parallel-group study designed to assess changes in select biomarkers of exposure (BoE) in generally healthy smokers following a 5 day in-clinic switch to…
- Trial name
- NCT06303115
- Testing
- Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine
- Where
- 5 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cigarette
A Consumer Use Behavior Study to Evaluate Puffing Topography and Average Daily Consumption of Heated Tobacco Products
This is a parallel design cohort consumer use study to measure the puffing topography of two HTP devices, with three variants of HTP consumables ("sticks,"), collectively referred to as the study investigational products (Study…
- Trial name
- NCT07175987
- Testing
- RDTH002581, RDTH002580, RDTH002582
- Where
- United Kingdom
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- RAI Services Company