Clinical trials: Smoking Addiction
Nicotine Use Disorder, Tobacco Use Disorder
Evaluation of the Addictive Potential of E-Cigarettes
This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.
- Trial name
- EVAPE (NCT04772014)
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Nicotine Use Disorder
Behavioral Memory Modulation in Nicotine Addiction
The purpose of the study is to see if a behavioral intervention known as retrieval-extinction training (RET) might affect craving in response to nicotine cues (e.g., pictures, videos and objects) and smoking behavior in men and…
- Trial name
- NCT03744559
- Testing
- Retrieval Extinction Training (RET), Control Retrieval Extinction Training (RET)
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Addiction, Vaping
Acute Effects of Vaping Nicotine on Cognition in Young Adults
To examine reward processing and cognitive control both with and without the influence of vaporized nicotine in young adults with no history of cigarette use using EEG and fMRI.
- Trial name
- NCT04901208
- Testing
- Nicotine pod
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Smoking, Smoking Behaviors
Human Perception of Odors and Odor Blockers
The goal of this clinical trial is to determine whether blockers of perception of key odorants in cigarette smoke have any utility in smoking cessation.
- Trial name
- NCT06191419
- Testing
- Odorants
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Tim McClintock
Nicotine Addiction, Drug Addiction
Clinical Trial of an Innovative Digital Therapeutic for Smoking Cessation With Biochemical Verification
This study is evaluating the efficacy of Treatment A for short-term smoking cessation through a blinded randomized controlled trial (RCT) vs.Treatment B.
- Conditions
- Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder
- Trial name
- NCT05440721
- Testing
- Treatment A with device Clickotine® (Active intervention), Treatment B with smoking education (control)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Click Therapeutics, Inc.
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Drug Addiction, Nicotine Dependence
Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray
Background: Smoking is the leading cause of preventable death in the United States, and researchers are interested in gaining a better understanding of the perceived beneficial effects of nicotine to help improve treatment…
- Trial name
- NCT01136642
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Addiction
Effect of Varenicline on Tobacco Addiction and on Abstinence-induced Cognitive Impairment
Background: Varenicline (Chantix ) is a drug that is approved by the Food and Drug Administration (FDA) to help people stop smoking.
- Trial name
- NCT01309685
- Testing
- Varenicline
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Smoking Behaviors
ACT Lung Health Intervention: Phase Two
This study aims to test a counseling and educational program designed to improve lung health through smoking cessation for Chinese and Korean American smokers at high risk for lung cancer.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking, Tobacco, Smoking, Cigarette
- Trial name
- NCT06945120
- Testing
- ACT Lung Health Intervention
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Smoking Cessation, Nicotine Addiction
Nicotine Receptor Levels and Smoking Cessation
The investigators propose to use positron emission tomography (PET) imaging to determine whether nicotinic receptor availability at pretreatment predicts smoking cessation success.
- Trial name
- NCT01788943
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Electronic Cigarette Use
Effect of Menthol on ENDS Users' Addiction and Exposure
The use of electronic nicotine delivery systems (ENDS; e-cigarettes) has reached epidemic levels among young people in the United States (US).
- Trial name
- NCT05338801
- Testing
- Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Florida International University
Tobacco Dependence
Improving Health for Aboriginal People Through Tobacco Related Research
Aim: To identify barriers and facilitators in the uptake of smoking cessation pharmacotherapies, tobacco prevention, doctor visits, smoking amongst youth, community held health priorities and barriers to research in Aboriginal…
- Trial name
- NCT01735448
- Testing
- Focus group, One-on-one interviews, Survey
- Where
- 3 sites in Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Queen Elizabeth Hospital
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Addiction, Smoking
Anodal Transcranial Direct Current Stimulation (tDCS) in the Treatment of Tobacco Addiction
The aim of this study is to determine whether a powerful technique of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), could reduce cigarette smoking and constitute a treatment of tobacco addiction.
- Trial name
- NCT01288183
- Testing
- active tDCS
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Nicotine Addiction, Smoking Cessation
Computer-Facilitated 5A's for Smoking Cessation in Primary Care
This study tests the use of handheld computer tablets to promote the integration of 5A's (Ask, Advise, Assess, Assist, Arrange) for smoking cessation in academic and community primary care clinics.
- Trial name
- NCT02046408
- Testing
- Computer Tablet
- Where
- 2 sites in United States
- Volunteers
- 961 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking (Tobacco) Addiction
Short-bout Handgrip Exercise Intervention
This study aims to examine the effect of practicing short-bout handgrip and isometric exercises on nicotine craving, smoking urges and withdrawal symptoms in adult smokers undergoing acute tobacco abstinence.
- Trial name
- NCT04059497
- Testing
- Exercise condition, Healthy diet condition
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Behavior, Addictive, Adolescent - Emotional Problem
"Juego de LLaves": Study Protocol of a Universal School-based Drug Use Prevention Program (PSIDUP)
"Juego de Llaves" is a universal school-based drug prevention program for adolescents aged 12-15 years. The outcome evaluation is critical to determine the quality of preventive interventions.
- Conditions
- Behavior, Addictive, Adolescent - Emotional Problem, Alcohol Abuse, Smoking Behaviors
- Trial name
- PSIDUP (NCT05442294)
- Testing
- Juego de Llaves
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Susana Al-Halabí
Nicotine Use Disorder
Neural Basis of Eating Behavior in Abstinent Smokers
The purpose of this research study is to better understand why people gain weight when they quit smoking by examining food intake and changes in brain activity in smokers when they are smoking as usual compared to when they have…
- Trial name
- SIT (NCT03438188)
- Testing
- Practice Quit Attempt
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania