Clinical trials: Smoking Behaviors
Stress Disorders, Post-Traumatic, Smoking
CPT and Smoking Cessation
Posttraumatic stress disorder (PTSD) and cigarette smoking are both associated with significant impairment in Veterans and cost to the Veterans' Affairs (VA) system.
- Trial name
- NCT01901848
- Testing
- Cognitive Processing Therapy (CPT), Bupropion, nicotine replacement therapy (NRT)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Lung Cancer
Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers
This research study involves taking an experimental anti-cancer dietary supplement called Sulforaphane (SF) or a placebo (product without any supplement content) over a period of twelve months in order to determine if it is a…
- Trial name
- NCT03232138
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Jian-Min Yuan, MD
Lung Cancer
Budesonide in Treating Patients With Lung Nodules at High Risk of Developing Lung Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of budesonide may keep lung cancer from forming in patients with lung nodules.
- Trial name
- NCT00321893
- Testing
- Budesonide
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- National Cancer Institute (NCI)
Smoking Cessation
Cognitive Remediation With D-Cycloserine
One hundred seventy-five eligible participants will be enrolled with aim of randomizing 60 to a double-blind, placebo-controlled trial of D-cycloserine added to cue-exposure treatment to prevent relapse to smoking.
- Trial name
- NCT01399866
- Testing
- D-cycloserine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cigarette Smoking
Analysis of Lipid Biomarkers of Exposure and Host Response
The purpose of this prospective, open-label, clinical trial is to establish the feasibility and validity of exhaled breath condensate (EBC) biomarkers for use in studies designed to evaluate harm reduction strategies of smoking.
- Trial name
- NCT00493831
- Testing
- nicotine polacrilex, transdermal system or inhaler
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nebraska
Schizophrenia, Cognition
Transcranial Direct Current Stimulation (tDCS) As A Treatment For Cigarette Craving and Cognitive Deficits in Schizophrenic
This is a study of the effects of tDCS on smoking, craving for cigarettes, cognition, and psychiatric symptoms in schizophrenic patients who are current smokers or have a history of regular cigarette smoking.
- Conditions
- Schizophrenia, Cognition, Cigarette Smoking
- Trial name
- TDCSSCHIZ (NCT02128919)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Nicotine Dependence
Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking
The purpose of this study is to evaluate the efficacy of the glycine antagonist, GW468816, compared with placebo on duration of abstinence and rates of relapse in recently quit female smokers in a randomized, double-blind…
- Trial name
- NCT00218465
- Testing
- GW468816
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- Massachusetts General Hospital
Current Smoker, Tobacco Smoking
Project MARS: Mobile-Assistance for Regulating Smoking
This study aims to investigate approaches to capitalize on states of vulnerability and receptivity to deliver real-time self-regulation prompts among smokers.
- Trial name
- MARS (NCT04376489)
- Testing
- Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants not experiencing negative affect & cigarettes are available), Messages recommending low effort strategies (participants experiencing negative affect & cigarettes are not available)
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Utah
Smoking, Tobacco
Carbon Monoxide Breath Sensor System Performance, Human Factors, and Usability Assessment Conducted in a Single Visit
Prospective, open label, single center clinical study enrolling 70 subjects to study Performance, Human Factors, and Usability for the Carbon Monoxide Breath Sensor System (COBBS)
- Trial name
- NCT03148613
- Testing
- Carbon Monoxide Breath Sensor System (COBSS), Bedfont - Micro+™ Smokerlyzer®
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- David Utley, MD
Smoking, HIV
Optimizing Smoking Cessation for People With HIV/AIDS Who Smoke
The single greatest health behavior change that could improve cardiovascular morbidity and associated mortality is to assist people living with HIV/AIDS who smoke to quit.
- Trial name
- NCT02460900
- Testing
- Varenicline, Positively Smoke Free, Standard of Care
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Maryland, Baltimore
Smoking
Smoke-free Air Coalitions in Georgia and Armenia
This is a matched-pairs community randomized controlled trial (CRCT) to examine the impact of coalitions promoting smoke-free air policies on individual secondhand smoke exposure (SHSe).
- Trial name
- NCT03447912
- Testing
- Intervention Condition
- Where
- 2 sites in Armenia, Georgia
- Volunteers
- 2,924 people, healthy volunteers welcome
- Sponsor
- Emory University
E-Cig Use
Responses to E-Cigarette Advertising
While conventional cigarette use continues to decline among youth and young adults, e-cigarette (EC) use is on the rise. The use of ECs during young adulthood, particularly 18 years of age, is especially alarming because it is…
- Trial name
- NCT04249219
- Testing
- Viewing e-cigarette ads
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Nicotine Dependence
A Smoking Cessation Treatment for Adult Women
The purpose of this study is to develop and pilot test a smoking cessation counseling that focuses on the perceived risks of quitting smoking (e.g., weight gain, managing cravings and negative affect, loss of enjoyment).
- Trial name
- NCT01422239
- Testing
- Tailored treatment, Standard Treatment
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking
Palatability of Experimental Cigarettes - Study 2
Smoking remains a leading cause of preventable disease and premature death worldwide. Approximately 1 out of every 5 deaths is associated with cigarette smoking, and roughly half of all daily smokers will die prematurely from…
- Trial name
- NCT01568905
- Testing
- Low level nicotine cigarette, Intermediate nicotine level cigarette, High level nicotine cigarette
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Dependence
Tobacco Dependence Treatment for Asian Americans
Nicotine dependence is very common among Asian Americans; yet, research on understanding and treating nicotine dependence in this group is almost nonexistent.
- Trial name
- NCT01091363
- Testing
- Standard, Deep Cultural
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Tobacco Use Disorder, Smoking Cessation
Deep rTMS and Varenicline for Smoking Cessation
The purpose of this study is to investigate the effect of deep repetitive transcranial magnetic stimulation (rTMS) using the insula H-coil on smoking outcomes in smokers receiving varenicline.
- Trial name
- NCT04083144
- Testing
- Deep Repetitive Transcranial Magnetic Stimulation (Active), Varenicline
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre for Addiction and Mental Health
Environmental Tobacco Smoke, Smoking Cessation
Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families
The purpose of this study was to explore the potential for directly targeting smoking cessation, regardless of motivation level, in a subsample of neonatal intensive care unit (NICU) parents with the ultimate goal of reducing…
- Trial name
- NCT04045964
- Testing
- nicotine replacement therapy (NRT), motivational advice, Quitline referral
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Alcoholism, Alcohol Abuse
Varenicline Treatment of Alcohol Dependence in Smokers
The purpose of this study is to determine whether varenicline is effective in the treatment of alcohol dependence in smokers.
- Conditions
- Alcoholism, Alcohol Abuse, Smoking, Alcohol Drinking
- Trial name
- NCT01553136
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Yale University
Smoking
User Acceptability of a Nicotine Lactate Delivery System (P3L)
This study will provide an initial assessment of the acceptability of the Nicotine Lactate Delivery System (P3L) after ad libitum use and the ability of combustible cigarette (CC) smokers to use P3L to maintain their customary…
- Trial name
- NCT02643693
- Testing
- P3L, VUSE, CC
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cessation
Determinants of Smoking Cessation Among Latinos
The goal of this study is to learn how neighborhood and individual factors affect the ability to stop smoking among Spanish-speaking Mexican American (MA) smokers who want to quit smoking.
- Trial name
- NCT01008748
- Testing
- Nicotine Replacement Therapy (NRT), Questionnaire, Counseling
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center