Clinical trials: Smoking Dependence
Smoking
Cue Reactivity in Virtual Reality: The Role of Context
The objectives of this proposal are to examine the role of context in a virtual reality (VR) environment and to explore the extent to which cues (i.e., contextual cues or explicit smoking cues) influence craving and physiological…
- Trial name
- NCT00862927
- Testing
- Breath Sample, Saliva Sample, Questionnaire
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Nicotine Dependence
Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes.
- Trial name
- NCT07698470
- Testing
- Oral Nicotine Pouch, Smoking Cue Reactivity Task
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Nicotine Dependence, Cigarette Smoking
Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smokers
The goal of this clinical trial is to learn whether lemongrass (Cymbopogon citratus) inhaler and liquid vapor interventions affect nicotine dependence and related biological and behavioral outcomes in adult smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Tobacco Use Disorder, Psychological Stress
- Trial name
- CCIVS (NCT07366294)
- Testing
- Lemongrass Inhaler, Lemongrass Liquid Vapor, Lemongrass Inhaler and Liquid Vapor
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Titin Andri Wihastuti
Nicotine Dependence
A Smoking Cessation Treatment for Adult Women
The purpose of this study is to develop and pilot test a smoking cessation counseling that focuses on the perceived risks of quitting smoking (e.g., weight gain, managing cravings and negative affect, loss of enjoyment).
- Trial name
- NCT01422239
- Testing
- Tailored treatment, Standard Treatment
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder
Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers
This study will examine extended exposure to cigarettes varying in nicotine content among adults with opioid use disorder. Those with opioid use disorder are at increased risk for smoking, nicotine dependence, and using high…
- Trial name
- P2S2 (NCT02250664)
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Dependence
Tobacco Dependence Treatment for Asian Americans
Nicotine dependence is very common among Asian Americans; yet, research on understanding and treating nicotine dependence in this group is almost nonexistent.
- Trial name
- NCT01091363
- Testing
- Standard, Deep Cultural
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Tobacco Dependence
Provider and Peer Delivered Youth Smoking Intervention
The purpose of this study was to determine whether a pediatric practice-based smoking prevention and cessation intervention increases abstinence rates among adolescents.
- Trial name
- NCT00435344
- Testing
- Pediatric Practice-Based Smoking Intervention
- Where
- United States
- Volunteers
- 2,711 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation, Nicotine Dependence
Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment
This research study will evaluate the preliminary efficacy of Pride Posts Plus, a social media-based smoking cessation treatment.
- Conditions
- Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
- Trial name
- NCT04461288
- Testing
- Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking Cessation, Tobacco Dependence
Smoking-cessation: A Spanish-Language Clinical Trial
The purpose of this study is to develop and test a series of culturally relevant and appropriate booklets in Spanish, designed to assist Hispanic smokers in quitting smoking and remaining smoke-free.
- Trial name
- NCT02611076
- Testing
- Stop Smoking for Good Intervention in Spanish (SS-SP), Usual care (UC)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Tobacco Dependence, Smoking Cessation
Tailoring Varenicline to Individual Needs (TVIN Study)
Varenicline is a partial nicotinic agonist which acts on alpha4 beta2 nicotinic receptors. It is presumed to alleviate withdrawal discomfort, but also to diminish rewarding effects of cigarettes.
- Trial name
- TVIN (NCT01206010)
- Testing
- Varenicline
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Smoking
Exercise to Enhance Smoking Cessation for Women at the YMCA
Approximately 21% of women continue to smoke cigarettes despite the increased risk of cancer and cardiovascular disease associated with cigarette smoking.
- Trial name
- NCT01615380
- Testing
- CBT+ Contact, CBT+ Exercise
- Where
- United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Nicotine Dependence, Tobacco Use Disorder
Family and Peer Influences on Nicotine Dependence in Medical Students of South Punjab
The goal of this cross-sectional observational study is to assess the impact of family functioning and peer pressure on nicotine dependence in medical students enrolled at medical colleges in South Punjab, Pakistan (both male and…
- Conditions
- Nicotine Dependence, Tobacco Use Disorder, Family Functioning, Peer Influence
- Trial name
- NCT07123389
- Where
- Pakistan
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Nishtar Medical University
Cannabis Use, Cannabis
Joint Effort 2.0: a Mobile Application With University Students
The purpose of this study is to evaluate quantitatively and qualitatively a mobile application, Joint Effort, targeting safe cannabis use among consumers.
- Conditions
- Cannabis Use, Cannabis, Cannabis Dependence, Cannabis Smoking
- Trial name
- JOINTEFFORT (NCT05620433)
- Testing
- Joint Effort, Brief normative feedback and standard information
- Where
- Canada
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-2 (NCT04449510)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
Background: Smoking is a difficult habit to quit, and some people find it more difficult to quit than others do. Nicotine is the substance in cigarettes that makes smoking so addictive.
- Trial name
- NCT01867411
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study
One of the most promising lines of investigation for the therapeutic use of hallucinogens in the 1960s and 1970s was in the treatment of drug dependence.
- Trial name
- NCT01943994
- Testing
- Psilocybin-assisted treatment, Nicotine Replacement Therapy (NRT)
- Where
- 2 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder
Smartphone-based Financial Incentives
Cigarette smoking during pregnancy increases risk for catastrophic pregnancy complications, growth retardation, other adverse fetal and infant health problems, and later-in-life chronic conditions among exposed offspring.
- Trial name
- NCT03922360
- Testing
- Smartphone-based Financial Incentives, Best Practices
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Nicotine Dependence, Tobacco Use Disorder
Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction
This is a 2-year study involving the progressive reduction in the nicotine content of cigarettes. The investigators believe that at the end of the study smokers of cigarettes with progressively reduced nicotine content will be…
- Trial name
- NCT00264342
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco