Clinical trials: Smoking E-cigarette
Tobacco Use
Expanding the Click City Tobacco Prevention Program to Include E-cigarettes and Other Novel Tobacco Products
The goal of this study is to modify a smoking prevention program for 5th and 6th grade students to also target vaping e-cigarettes.
- Trial name
- NCT03682900
- Testing
- Click City®: Tobacco, Usual Tobacco Curriculum
- Where
- United States
- Volunteers
- 2,673 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Vaping, Preventive Psychiatry
Network Intervention to Prevent Vaping
Rates of adolescent vaping are increasing rapidly. Current high school student use of electronic vaping products (EVPs) rose from 1.5% in 2011 to 20.8% in 2018 - an increase from 220,000 to 3.05 million adolescent users.
- Conditions
- Vaping, Preventive Psychiatry, Social Networking
- Trial name
- NCT04678245
- Testing
- Above the Influence-Vaping (ATI-V)
- Where
- United States
- Volunteers
- 3,950 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Smoking, Healthy
In-vivo Effects of E-cigarette Aerosol on Innate Lung Host Defense
While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use.
- Trial name
- Cinimic (NCT03700892)
- Testing
- Cinnamaldehyde e-liquid, PG/VG e-liquid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Electronic Cigarettes
The Effect of Electronic Cigarette Liquid Characteristics in Smokers.
The purpose of this study is to determine differences in nicotine delivery, user behaviors, subjective effects, and physiological effects, when cigarette smokers use an electronic cigarette with different nicotine (and sweetener)…
- Trial name
- NCT03861078
- Testing
- Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Vaping Behavior
High Impact E-cigarette Advertisement Features
This randomized controlled trial aims to examine the effects of high-impact e-cigarette advertisement features among young adults of various tobacco-use statuses.
- Trial name
- NCT06704295
- Testing
- Control ad with dark gray product with tobacco flavor name, Dark gray product with strawberry flavor name, Colorful (strawberry color) product with strawberry flavor name
- Where
- United States
- Volunteers
- 3,083 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Smoking, Tobacco Use
JUUL vs. Mod E-cigarette Study
Some smokers who try e-cigarettes transition completely from cigarettes to e-cigarettes, but others continue to use both products, or abandon e-cigarettes and return completely to cigarettes.
- Trial name
- NCT04237272
- Testing
- Pod System E-cig, Customizable Tank E-cig, Control
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Vaping
Responses to E-cigarette Message Source and Presentation
The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who…
- Trial name
- NCT06274723
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tobacco Dependence
European Regulatory Science on Tobacco: Policy Implementation to Reduce Lung Diseases (EUREST-PLUS)
The main objective of EUREST-PLUS is to monitor and evaluate the impact of the Tobacco Products Directive (TPD) within the context of FCTC ratification at an EU level.
- Trial name
- EUREST-PLUS (NCT02773836)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 6,036 people, healthy volunteers welcome
- Sponsor
- European Network For Smoking and Tobacco Prevention
Vaping
Graphic Messages to Prevent E-Cigarette Use Among Black and Latino Adolescents
The aim of this study is to determine if graphic messages prevent future vaping use among African American and Latino adolescents.
- Trial name
- NCT04899999
- Testing
- Financial reward graphic message, Health reward graphic message, Self-efficacy graphic message
- Where
- United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Nicotine Vaping
Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes
The investigators will examine the relationship between nicotine flux, nicotine form, and the rate and dose of nicotine delivery.
- Trial name
- NCT05706701
- Testing
- Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yale University
Energy Intake, Food Intake
The Acute Effect of Vaping on Food Intake
This study assesses the acute effects of a standardized 20-minute vaping episode compared to a non-vaping control condition on ad libitum food intake during a 30-minute buffet meal, occurring approximately 45 minutes after the…
- Conditions
- Energy Intake, Food Intake, E-Cig Use, Appetite
- Trial name
- NCT04219189
- Testing
- Vaping condition, Control condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence, Other Tobacco Product, Bladder Cancer
Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers
This study will test feasibility, in smokers with lung, head \& neck, and bladder cancers, that examines the effect of e-cigarette substitution, on measures of smoking-related toxicity and medical outcomes.
- Conditions
- Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
- Trial name
- NCT02648178
- Testing
- HALO
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
This trial studies what would happen if the nicotine levels in cigarettes are greatly reduced, but electronic cigarettes containing different amount of nicotine are available.
- Trial name
- NCT02964182
- Testing
- Cigarette, Nicotine Replacement, Questionnaire Administration
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Electronic Cigarette Use
Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems
This is a randomized, parallel-group open-label trial to evaluate respiratory symptoms in ENDS users switching from banned flavors to a non-banned flavor (tobacco) or 'tobacco free' nicotine pouches.
- Trial name
- CRoFT (NCT05423340)
- Testing
- E-cigarette Flavor, Tobacco Free Nicotine Pouch
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking Cessation, Electronic Cigarette Use
CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes
Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use.
- Conditions
- Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- CAN-DOSE (NCT06087328)
- Testing
- Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation
Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes
This single-group, small-scale, open-label study (N= 25 to 50) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- BuZonE (NCT04388319)
- Testing
- Zonisamide, Bupropion, Halo G6 e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Tobacco Smoking
E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia
The purpose of this study is to assess if access to an electronic nicotine delivery device, or e-cigarette, in addition to nicotine patch (21 mg) can help reduce cigarette smoking among individuals diagnosed with schizophrenia…
- Trial name
- NCT02918630
- Testing
- Nicotine Patch, E-cigarette
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The University of Texas Health Science Center, Houston
Smoking, Cigarette
Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures
The overall aim of the study is to evaluate the provision of e-cigarette (EC) versus NRT on smoking behavior, product use patterns and continued use, and iCO, a biomarker of toxicant exposure, among a sample of recent QL…
- Trial name
- NCT03502200
- Testing
- JUUL, Treatment As Usual
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking Cessation
Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes
The purpose of this study is to develop and test a series of booklets designed to assist smokers of tobacco cigarettes who are also using e-cigarettes (dual users) in quitting smoking and remaining smoke-free.
- Trial name
- NCT02416011
- Testing
- GENERIC, eTARGET
- Where
- United States
- Volunteers
- 2,896 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute