Clinical trials: Smoking Reduction
- Condition Smoking Reduction
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd and TSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01369693)
- Testing
- Buccal administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Smoking Cessation
The Effectiveness of Using E-Cigarettes for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers
The goal of this clinical trial is to evaluate effectiveness of using e-cigarettes as harm reduction strategy for smoking cessation and decreasing risk of diseases in heavy smokers.
- Trial name
- NCT05639790
- Testing
- Electronic cigarettes + Health Counselling, Health Counselling
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shenzhen Smoore Technology Limited
Smoking Cessation, Harm Reduction
Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT
This study will determine whether a range of products along the reduced-risk continuum can reduce smoke exposure for individuals who fail to quit smoking using current medically approved nicotine replacement therapy (NRT)…
- Trial name
- NCT06088862
- Testing
- Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking
Reduced Exposure Study in Smokers Using the Tobacco Heating System 2.2 (THS 2.2) for 5 Days in a Confinement Setting
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 consecutive days by adult Japanese healthy smokers affects the levels of biomarkers of exposure for selected…
- Trial name
- NCT01970982
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Japan
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Reduced Exposure Study Using CHTP 1.0 During 5 Days in Confinement.
The overall goal of the study is to demonstrate the reduction of biomarkers of exposure (BoExp) to selected harmful and potentially harmful constituents (HPHCs) in adult smokers switching for 5 days from conventional cigarette…
- Trial name
- NCT02503254
- Testing
- CHTP 1.0, Conventional Cigarette (CC)
- Where
- Poland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Tobacco
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07598136
- Testing
- P2613422, P2611222, P2615522
- Where
- 7 sites in United States
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking, Tobacco
A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System
This is a multi-site, open-label, single arm study to evaluate the rate of smoking abstinence by the end of the study with healthy adult consumers of cigarettes when provided with an e-cigarette over a 13 week study period.
- Trial name
- NCT07879638
- Testing
- FT25614, FT25615, FT25616
- Where
- 5 sites in United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking, Tobacco Smoking
Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
This was a randomized, controlled, open-label, 4 parallel arm study with a stratified randomization by sex (a quota for each sex [females and males] of at least 40% overall).
- Conditions
- Smoking, Tobacco Smoking, Tobacco Use
- Trial name
- NCT05599451
- Testing
- THS Blade device, THS Induction Mono device, THS Induction Mid device
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Inflammation, Oxidative Stress
Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking
This is a cross-sectional 3-group study with subjects enrolled and matched by region (Asia, Europe), age, sex, and average daily product consumption over the last 2 years as self-reported.
- Conditions
- Inflammation, Oxidative Stress, Smoking, Smoking Abstinence
- Trial name
- NCT05385055
- Testing
- THS use, Cigarette smoking, Smoking abstinence
- Where
- 37 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 974 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting and 85 Days in an Ambulatory Setting
The main goal of the study is to evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS 2.2) for 5 days in confinement and after 85 days of product use in an ambulatory setting, by Japanese adult healthy smokers results in a…
- Trial name
- NCT01970995
- Testing
- THS 2.2 Menthol (mTHS 2.2), Smoking Abstinence (SA), Menthol Conventional Cigarette (mCC)
- Where
- Japan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Tobacco
A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07172438
- Testing
- P2611222, P2615022, P2615122
- Where
- 27 sites in United States
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine
This study will evaluate the effects of a reward devaluation strategy, which has been researched in the past, combined/augmented with the medication d-cycloserine in assisting smokers to switch from combustible cigarette (CC) to…
- Trial name
- NCT05994703
- Testing
- d-cycloserine, Juul e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking Cessation, Smoking Behaviors
Clinical Learning Study for a Mobile Smoking Cessation Program
The purpose of this study are to obtain learnings regarding the Digital Therapeutic (DTx) experience of Clickotine, including acceptability and preference of the overall program and specific DTx components, as well as to obtain…
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking Reduction, Smoking, Cigarette
- Trial name
- NCT04857515
- Testing
- Clickotine®
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Click Therapeutics, Inc.
Nicotine Addiction, Cigarette Smoking
Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use
Three hundred-twenty (320) adult smokers of menthol or non-menthol combustible cigarettes will be recruited and randomly assigned to one of five groups (n=64/group), who will be asked to switch for 12 weeks to ad libitum use of…
- Trial name
- DUAL (NCT02870218)
- Testing
- Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Nicotine, Vaping
Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoking Abstinence
To demonstrate the reduction of Biomarkers of Exposure (BoExp) to selected harmful and potentially harmful constituents (HPHC) in smokers switching from cigarette (CIG) to P4M3, an Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Nicotine, Vaping, Nicotine Vaping
- Trial name
- NCT05487456
- Testing
- P4M3 CA35, P4M3 CM35, CIG
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Use Disorder, Tobacco Dependence
Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers' Urge to Smoke
This study will consist of 2 phases. Phase 1 will be a one day crossover study to see the effects of study product on a smoker's desire to smoke, measured by changes in scores on questionnaires given over time.
- Conditions
- Tobacco Use Disorder, Tobacco Dependence, Smoking
- Trial name
- NCT01428310
- Testing
- Anatabloc(TM), CigRx(R)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Rock Creek Pharmaceuticals, Inc.
Thromboangiitis Obliterans (Buerger's Disease)
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the…
- Trial name
- NCT07215923
- Testing
- ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Antidote Therapeutics, Inc
Smoking Reduction, Smoking Behaviors
Assessment of the Pivot Breath Sensor: Single-Arm Cohort Study
Prospective open label, single center study enrolling up to 220 participants to evaluate the effect of the Pivot Breath Sensor on a user's attitudes towards quitting smoking and smoking behavior.
- Conditions
- Smoking Reduction, Smoking Behaviors, Smoking, Tobacco, Smoking Cessation
- Trial name
- NCT04133064
- Testing
- Pivot Breath Sensor
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Jennifer Marler, MD
Cigarette Smoking Behavior
Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study
The goal of this clinical trial is to learn about the role of flavored on!® nicotine pouch products (the research products), an oral tobacco-leaf-free product, in the replacement of cigarettes with the use of the research…
- Trial name
- NCT06072547
- Testing
- Access to all varieties of on! 4mg nicotine pouches (Berry, Citrus, Cinnamon, Wintergreen, Mint, Coffee, and Original), Access to Original on! 4mg nicotine pouches, Non-Flavored then complete flavor on! nicotine pouches
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC