Clinical trials: Smoking-related Pathology
Chronic Obstructive Pulmonary Disease
A Study About Association Between Microbiome, Metabolome and Clinical Characteristics in COPD Patients
The goal of this observational registry study is to compare characteristics of gut and sputum microbiome and metabolome among COPD patients with significant smoking history, COPD patients without significant smoking history and…
- Trial name
- NCT06101459
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Smoking ( Cigarette), Breastfeeding
Prevention of Postpartum Smoking Relapse and Related Health Consequences by Breastfeeding Promotion
The objective of this randomized controlled trial is to examine the efficacy of a new intervention to prevent postpartum smoking relapse and related health consequences through breastfeeding promotion.
- Trial name
- NCT07661550
- Testing
- Breastfeeding promotion
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Electronic Cigarette Related Lung Damage
Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology
A two-center, longitudinal assessment of 40 electronic cigarette users and 40 healthy controls at the initial visit and a follow-up visit 12 months later.
- Trial name
- ECig (NCT06856525)
- Testing
- Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Y. Michael Shim, MD
Cardiovascular Diseases, Chronic Obstructive Pulmonary Diseases
The Efficacy and Safety of Electronic Cigarettes: a 5-year Follow-up Study
The main aim of this multicentric 5-year follow-up study is to evaluate for the first time the long-term efficacy and safety (in terms of smoking-related serious diseases requiring hospitalization) of e-cigarette smoking…
- Conditions
- Cardiovascular Diseases, Chronic Obstructive Pulmonary Diseases, Cancer of the Lung, Cancer of the Bladder
- Trial name
- NCT01785537
- Where
- Italy
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Recurrence, Smoking Cessation
Relapse Prevention With Varenicline
This study aims to determine if varenicline (Chantix®), currently used as a smoking cessation aid, will decrease the likelihood of relapse to smoking following a programmed lapse in the laboratory.
- Conditions
- Recurrence, Smoking Cessation, Substance-Related Disorders
- Trial name
- 0815 (NCT00944554)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Smoking Cessation, Chronic Obstructive Pulmonary Disease (COPD)
SAW Lung Microbiome Study in Smokers and Never-smokers
The trial aims to analyse changes in the microbiome of the lower airways after smoking cessation. Microbiome analyses (upper airway swabs, bronchoalveolar lavage, transbronchial brushing) are conducted in smokers before and 6…
- Conditions
- Smoking Cessation, Chronic Obstructive Pulmonary Disease (COPD), Healthy, Microbial Colonization
- Trial name
- NCT03562442
- Testing
- Smoking cessation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Research Center Borstel
Smoking Cessation, Anxiety
Smoking Cessation, Anxiety, Pain Relationship
Smoking, anxiety and pain are clearly related conditions. We aimed to reveal the relationship between smoking cessation before surgery and preoperative anxiety, postoperative anxiety and pain in chronic smokers.
- Conditions
- Smoking Cessation, Anxiety, Pain
- Trial name
- NCT04405219
- Testing
- The Relationship Between Preoperative Smoking Cessation, Anxiety, Pain
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Nicotine Dependence, Tobacco Use
Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers
The project is designed to examine the effectiveness of strategies to increase access to treatment for tobacco use and dependence among rural Veteran smokers.
- Trial name
- NCT01892813
- Testing
- Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge
- Where
- United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Mark Vander Weg
Tobacco Use Disorder, Schizophrenia
Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls
This project tests two hypotheses concerning the low smoking cessation rates in smokers with schizophrenia. The first hypothesis is that smokers with schizophrenia experience stronger and more sustained effects of smoking…
- Trial name
- WREN (NCT01214005)
- Testing
- smoking abstinence
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
Asthma in Children, Wheezing
Secondhand Smoking in Asthmatic Children
This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.
- Trial name
- NCT03099902
- Testing
- Lung function, White blood cell DNA extraction, Urinary testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Cigarette Smoking
Tailored Tobacco Quitline for Rural Veterans
The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers.
- Trial name
- NCT01592695
- Testing
- Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Cannabis Intoxication
The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking
This study was authorized by the California Legislature (Assembly Bill 266, the Medical Marijuana Regulation and Safety Act to help with detection of driving under the influence of cannabis.
- Trial name
- NCT02849587
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Smoking Cessation
Gut Hormones in Obesity, Nicotine and Alcohol Dependence
The "Gut Hormones in Addiction" study is a proof-of-concept experimental medicine human study to answer the following questions: 1.
- Conditions
- Obesity, Smoking Cessation, Alcoholism
- Trial name
- GHADD (NCT02690987)
- Testing
- Exenatide, Desacyl ghrelin, Saline
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking
Functional Capacity, Subjective Dyspnea and Fatigue in Smokers
Smoking remains a significant public health problem among the young adult population. Epidemiological studies in Turkey show a steadily decreasing age of smoking initiation and a remarkably high rate of smoking among…
- Trial name
- NCT07520981
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Istinye University
Tobacco Use Disorder
Smoking Cessation Treatment for Smokers With Obesity
This study aims to developed an empirically validated psychological intervention protocol for smoking cessation among individuals with excess weight.
- Trial name
- NCT04332029
- Testing
- CBT + WGP + CM, CBT + WGP
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Tobacco Use Cessation, Sleep Disorders
Impact of Smoking Cessation on Sleep - 5
Smoking is a major health problem with a direct link to elevated heart- and lung-related problems. Nicotine is highly addictive, which makes quitting difficult and relapse after quitting highly probable.
- Trial name
- NCT00132821
- Testing
- Bupropion, Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Smoking
N-acetylcysteine for Tobacco Use Disorder
The purpose of this study is to assess the effects of administering N-Acetylcysteine (NAC) to assist in initial cessation and/or relapse prevention in adult cigarette smokers.
- Trial name
- NCT02737358
- Testing
- N-acetylcysteine (NAC)
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Schizophrenia, Bipolar Disorder
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Adults with serious mental illness (SMI) are disproportionately affected by medical comorbidity, earlier onset of disease, and 10 to 25 years reduced life expectancy compared to the general population.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Recurrent, Obesity
- Trial name
- NCT04481737
- Testing
- Peer-delivered and Technology Support Integrated Illness Management and Recovery, Peer support
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center