Clinical trials: Sodium Bicarbonate
Oral Hygiene
An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
The aim of this study is to compare the stain effect on teeth of twice daily brushing with a 67% sodium bicarbonate containing toothpaste versus standard toothpaste (not containing sodium bicarbonate) for six weeks whilst using a…
- Trial name
- NCT01962493
- Testing
- Sodium bicarbonate/ Sodium Fluoride, Sodium fluoride, Chlorhexidine digluconate
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Comparative Evaluation of the Effect on Blood Pressure of an Equivalent Content of Sodium in the Form of Bicarbonate of Sodium and in the Form of Sodium Chloride, on "Sensitive Sodium" Subjects
Many large-scale epidemiological studies have established a link between the average consumption of table salt (sodium chloride) and blood pressure.
- Trial name
- SODIVASC (NCT02561325)
- Testing
- Sodium Bicarbonate and Sodium chloride
- Where
- France
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Local Anesthesia
Effectiveness of Sodium Bicarbonate Buffered Anaesthetic Solution on Pain During Injection
This study will test the effectiveness of addition of Sodium Bicarbonate as a buffering agent to the anaesthetic solution on minimizing the pain of injection and increasing the onset time and potency of the anaesthetic solution…
- Trial name
- NCT05473819
- Testing
- Buffered Local Anesthesia, Conventional Unbuffered Local Anesthesia
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Gingivitis
A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
The aim of this study is to develop a daily use toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride with the intention of providing improved/ fast gum healing.
- Trial name
- NCT04737538
- Testing
- Experimental Dentrifrice, Positive control dentifrice, Negative control dentifrice
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dysglycemia, Type 2 Diabetes Mellitus
Alkaline Diet for Insulin Sensitivity
The purpose of this study is to test the effect of increasing the body pH acutely with an alkaline medication (sodium bicarbonate, NaHCO3, sodibic) on glucose metabolism post meal in non diabetic subjects with normal renal…
- Trial name
- ADIS (NCT02501343)
- Testing
- Sodium Bicarbonate Oral Capsule
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Supplementation, Sport
Sodium Bicarbonate Supplementation in Combat Sports Athletes
The purpose of this study was to verify the effect of 10-day sodium bicarbonate (NaHCO3) and placebo (PLA) supplementation on physical and specific performance capacity, as well as concentrations of the selected biochemical blood…
- Trial name
- NCT03406065
- Testing
- Sodium bicarbonate supplementation
- Where
- Poland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Fluid Retention, Sodium Retention
The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the…
- Conditions
- Fluid Retention, Sodium Retention, Heat Stress, Dehydration (Physiology)
- Trial name
- AMP2 (NCT05092854)
- Testing
- PR Lotion - AMP Human Performance, AminoVital - Rapid Recovery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Chronic Kidney Disease
Pilot Study of Sodium Bicarbonate in Generally Healthy People With Low Bicarbonate
The goal of this pilot study is to determine whether oral sodium bicarbonate can raise low serum bicarbonate concentration in people without chronic kidney disease (CKD).
- Trial name
- NCT02743650
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy, Athlete
Effects of Sodium Bicarbonate on Endurance Performance
This study is investigating whether taking sodium bicarbonate, a common supplement used by endurance athletes, can improve cycling performance during prolonged exercise and in a time trial.
- Conditions
- Healthy, Athlete, Well-trained Athletes, Performance
- Trial name
- SBEP (NCT07171047)
- Where
- Austria
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Salzburg
Exercise-Induced Fatigue, Athletic Performance
The Effect of Individual Sodium Citrate Consumption on Repeated Sprint Performance in Female Soccer Players
The aim of this research is to determine whether sodium citrate supplementation, taken at the best individual time, would improve repeated sprint performance in professional female soccer players.
- Conditions
- Exercise-Induced Fatigue, Athletic Performance, Soccer
- Trial name
- ITSCORE-F (NCT07737327)
- Testing
- Sodium Citrate Oral Product
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Sports Nutritional Physiological Phenomena
Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation
The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance.
- Trial name
- NCT03505970
- Testing
- Sodium bicarbonate, Maltodextrin
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Blood Pressure
Evaluation of the Effect of Sodium Bicarbonate Water on Blood Pressure in Normotensive Subjects
ROX_TENSIO18 is a randomised cross-over trial and the main objective is to evaluate the effect of daily consumption of sodium bicarbonate water for 15 days on blood pressure.
- Trial name
- ROX_TENSIO18 (NCT04282512)
- Testing
- Sodium bicarbonate-rich mineral water
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- My Goodlife SAS
Health Adults
Sodium Bicarbonate Solution Enhances Lens Cleanliness in Magnetically Controlled Capsule Endoscopy
Magnetically controlled capsule endoscopy (MCE) is a noninvasive alternative to conventional gastroscopy with comparable diagnostic accuracy.
- Trial name
- NCT07877506
- Testing
- Sodium Bicarbonate Solution
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Oral Mucositis
Effect of Black Mulberry Lollipop on Prevention of Oral Mucositis in Children
THE EFFECT OF BLACK MULBERRY LOLLIPOP AND SODIUM BICARBONATE USED IN ORAL CARE ON PREVENTION OF ORAL MUCOSITIS AMONG CHILDREN RECEIVING CHEMOTHERAPY DUE TO CANCER
- Trial name
- NCT04800549
- Testing
- Oral Mucositis
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Sapanca Ilce Devlet Hastanesi
Heartburn
Comparison of Two Omeprazole-Containing Products for Relief of Frequent Heartburn (MK-0764A-036)
This study will evaluate a single ingredient product (omeprazole 20 mg) with a combination product capsule (omeprazole 20 mg + sodium bicarbonate 1100 mg) in participants with frequent heartburn.
- Trial name
- NCT01587885
- Testing
- Omeprazole 20 mg + Sodium Bicarbonate 1100 mg, Omeprazole 20 mg
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bayer
Sodium Bicarbonate, Alkalosis, Metabolic
Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task
The aim of this study was to verify if sodium bicarbonate (NaHCO3) suplementation promotes changes in the performance, muscular activity and strength of individuals trained during the intermittent and intense task .
- Conditions
- Sodium Bicarbonate, Alkalosis, Metabolic, Electromyography, Fatigue
- Trial name
- NCT03837886
- Testing
- Sodium bicarbonate, Calcium carbonate
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
General Anesthesia
Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Anesthetized Children
Extravasation is an unintentional injection or leakage of fluids in the perivascular or subcutaneous space. Extravasation can be associated with tissue injury with various level of severity and long term consequences.
- Trial name
- NCT01219322
- Testing
- Sodium bicarbonate, normal saline
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cognition, Sodium Bicarbonate
Exercise-Induced Lactate and Cognitive Function (ExLBC)
A single bout of exercise can rapidly improve cognitive functions including memory, attention, and executive functions, which help us navigate through everyday life.
- Conditions
- Cognition, Sodium Bicarbonate, Lactate, Exercise
- Trial name
- NCT06817681
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- 2 sites in Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Athletes
The Acute Effects of Combined Caffeine and Sodium Bicarbonate Consumption on Isometric Mid-thigh Pull
The aim of this study was to investigate the effects of isolated and combined caffeine and sodium bicarbonate consumption on acute isometric mid-thigh pull (IMTP) strength, and verify whether they are cumulative, neutral or…
- Trial name
- NCT05883046
- Testing
- Performance-Enhancing Substances, Baseline (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bozok University
Nephropathy
A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of Contrast-Induced Nephropathy (CIN) after cardiac catheterization.
- Trial name
- PROTECt (NCT00579995)
- Testing
- Oral N-Acetylcysteine, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska