Clinical trials: Sodium Depletion
Hyponatremia
Maintenance Intravenous Fluids in Children
Hyponatraemia arises in between 20% and 45% of sick hospitalized children. An important reason for this high incidence could be use of hypotonic fluids in sick children for maintenance fluid therapy.
- Trial name
- NCT00621348
- Testing
- Isotonic fluid, Hypotonic fluid
- Where
- India
- Volunteers
- 167 people
- Sponsor
- All India Institute of Medical Sciences
Hyponatremia
Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia
Hyponatremia is a condition in which there is a low sodium level in the blood. Individuals with cirrhosis may develop low blood sodium as a complication of their liver disease.
- Trial name
- NCT01890694
- Testing
- Tolvaptan, Hepatic Encephalopathy Assessment, Quality of Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- NYU Langone Health
Renal Failure, Hyponatremia
Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation
The aim of this study is to evaluate the effect of prolonged administration of albumin and midodrine on the prevention of complications (renal failure, sepsis, hemorrhage, hepatic encephalopathy and hyponatremia) in patients with…
- Conditions
- Renal Failure, Hyponatremia, Sepsis, Hepatic Encephalopathy
- Trial name
- MACHT (NCT00839358)
- Testing
- albumin, Midodrine
- Where
- Spain
- Volunteers
- 199 people
- Sponsor
- Hospital Clinic of Barcelona
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
Tolvaptan Versus Fluid Restriction in SIADH
Context. The relevance of hyponatremia has been acknowledged by guidelines from the United States of America (2013) and Europe (2014). However, treatment recommendations differ due to limited evidence. Objective.
- Conditions
- Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion, Pituitary
- Trial name
- NCT04119206
- Volunteers
- 334 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hyponatremia
Relationship Between Heat Wave and Hyponatremia
The objective of this study is to explore the relationship between moderate to severe hyponatremia and heat.
- Trial name
- NCT02012660
- Testing
- Seasonality
- Where
- Switzerland
- Volunteers
- 28,734 people
- Sponsor
- University Hospital, Geneva
Small Cell Lung Cancer
Effect of Hyponatremia in Small Cell Lung Cancer
In this retrospective study, the investigators determined the frequency of hyponatremia in small cell lung cancer and the prognosis. 126 (27%) of 466 patients were hyponatremic.
- Trial name
- NCT04451460
- Volunteers
- 466 people
- Sponsor
- Ankara City Hospital Bilkent
Hyponatremia
Safety and Efficacy of Conivaptan for the Correction of Hyponatremia in Neurological Patients
Low sodium levels (hyponatremia) are a frequent occurrence in medically ill patients, and in particular those with neurological injury.
- Trial name
- NCT00684164
- Testing
- Conivaptan, D5
- Where
- United States
- Sponsor
- Columbia University
Hyponatremia
0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children
The primary objective of this study is to compare the mean serum sodium at 48 hours following the initiation of therapy with either 0.45% NaCl/dextrose 5% or 0.9% NaCl/dextrose 5%, in children requiring maintenance IV fluid…
- Trial name
- NCT00632775
- Testing
- Hypotonic (0.45% NaCl/5% dextrose) IV maintenance fluids, Isotonic (0.9% NaCl/5% dextrose) IV maintenance fluids
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Hyponatremia
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia
The objective of this study is to evaluate the efficacy, safety and pharmacokinetics of intravenous conivaptan in pediatric subjects with abnormally low concentration of sodium in blood.
- Trial name
- NCT01451411
- Testing
- Conivaptan hydrochloride
- Where
- 3 sites in United States, Colombia
- Volunteers
- 4 people
- Sponsor
- Cumberland Pharmaceuticals
COVID-19
Relation Between COVID-19 Pts and Hyponatremia in Adreno Ortical Insufficient Patients.
Hyponatremia in COVID-19 patients with adrenal insufficiency
- Trial name
- NCT05408481
- Testing
- Serum cortisol level
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hyponatremia, Osmotic Demyelination Syndrome
Hyponatremia - Complications, Prognosis, Epidemiology in Finnish Tertiary Care
Study Objectives and Hypothesis To determine the incidence of hyponatremia at TYKS and the factors associated with it. To assess how rapidly hyponatremia was corrected and how the rate of correction affected patient prognosis.
- Conditions
- Hyponatremia, Osmotic Demyelination Syndrome, Alcohol Use Disorder
- Trial name
- NCT07430787
- Where
- Finland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Turku
Hyponatremia, SIADH
Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia
Hyponatremia is the most common electrolyte derangement occurring in hospitalized patients. It is usually classified as hypovolemic, euvolemic or hypervolemic.
- Conditions
- Hyponatremia, SIADH, Liver Failure, Kidney Failure
- Trial name
- EMPOWER (NCT04447911)
- Testing
- Empagliflozin 25 MG
- Where
- 6 sites in Germany, Netherlands and 1 more
- Volunteers
- 113 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyponatremia
Study of Efficacy & Safety of Oral YM087 in Subjects With Euvolemic or Hypervolemic Hyponatremia
Study of efficacy \& safety of oral YM087 in subjects with euvolemic or hypervolemic hyponatremia
- Trial name
- NCT00492037
- Testing
- YM087 oral
- Where
- 29 sites in Belgium, Finland and 7 more
- Volunteers
- 83 people
- Sponsor
- Cumberland Pharmaceuticals
Exercise Induced Hyponatremia
The Effects of Estradiol and Progesterone on Arginine Vasopressin Regulation and Serum Sodium Concentration
Women are at greater risk for exercise-induced hyponatremia (low blood sodium concentration) and this risk has been attributed to their lower body weight and size, excess water ingestion and longer racing times relative to men.
- Trial name
- NCT00589134
- Testing
- Gatorade Endurance Formula, ganirelix acetate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yale University
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
An Observational Study Measuring Outcomes in Cancer Patients Treated for Moderate to Severe Hyponatremia in Italy
This observational, prospective, non-interventional study will include cancer patients who need a treatment for hyponatraemia secondary to SIADH.
- Conditions
- Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion, Cancer
- Trial name
- ASSERT (NCT02573077)
- Where
- 20 sites in Italy
- Volunteers
- 69 people
- Sponsor
- Otsuka Pharmaceutical Europe Ltd
Hyponatremia, Accidental Falls
Hyponatremia in the Prevention of Hospitalized Patients Falls
Cross ecological quasi-experimental study to assess effectiveness of early intervention in the diagnosis and treatment of hyponatremia in the prevention of hospitalized patients´ falls.
- Trial name
- PRECAHI (NCT03265691)
- Testing
- Early detection and treatment of hyponatremia, No Intervention (SOC)
- Where
- Spain
- Volunteers
- 124 people
- Sponsor
- Mª del Carmen Lobo Rodríguez
Hyponatremia
THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation
The purpose of this study is to determine the safety and efficacy of lixivaptan in the treatment of hyponatremia in patients with congestive heart failure.
- Trial name
- NCT00578695
- Testing
- lixivaptan
- Where
- 287 sites in United States, Argentina and 13 more
- Volunteers
- 652 people
- Sponsor
- CardioKine Inc.
Bronchiolitis, Seizures
Seizures in Infants Hospitalized in Pediatric Intensive Care Unit for Bronchiolitis
Bronchiolitis is the leading cause of pediatric intensive care unit admission in infants. Seizures during bronchiolitis may be a neurological complication of respiratory viruses but also of the treatments.
- Conditions
- Bronchiolitis, Seizures, Hyponatremia
- Trial name
- BRONCHIOLITIS (NCT04022486)
- Testing
- Incidence, management and risk factors of seizure
- Where
- France
- Volunteers
- 805 people
- Sponsor
- Hospices Civils de Lyon
Acute Hyponatremia
Bipolar Versus Monopolar Resection of Benign Prostate Hyperplasia
Aim of this prospective clinical study was to compare two different surgical techniques and used solutions on serum electrolytes, bleeding and Transurethral Resection of Prostate (TURP) syndrome undergoing TURP.
- Trial name
- NCT02681471
- Testing
- 5% Mannitol, 0,9% Sodium chloride, monopolar resectoscope
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Inappropriate ADH Syndrome, Hyponatremia
Efficacy and Safety of SR121463B in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion
To assess the efficacy of SR121463B in correcting hyponatremia in patients with syndrome of inappropriate antidiuretic secretion (SIADH).To assess the long-term efficacy of SR121463B in maintaining normal levels of serum sodium…
- Trial name
- SIADH (NCT00264927)
- Testing
- SR121463B
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 77 people
- Sponsor
- Sanofi