Clinical trials: Sodium Retention
Alcoholic Liver Cirrhosis, Ascites
Prevention of Decompensation in Liver Cirrhosis
The purpose of this study is to determine whether losartan, an angiotensin II blocker prevents the sodium retention in patients with liver cirrhosis and by that reduces the fluid retention.
- Trial name
- NCT00239096
- Testing
- losartan (drug)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Liver Cirrhosis
Treatment of Sodium Retention in Liver Cirrhosis With Dexamethasone
Accumulation of salt and water in patients with liver disease (so called liver cirrhosis) is possibly related to the increased effect of steroid hormones on salt reabsorption in the kidney.
- Trial name
- NCT01311167
- Testing
- Dexamethasone
- Where
- 3 sites in Switzerland
- Volunteers
- 2 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyponatremia, Hypernatremia
Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
The goal of this clinical trial is to determine if isotonic or hypotonic fluids are more effective in maintaining serum sodium levels in neonates undergoing maintenance fluid therapy post-surgery.
- Conditions
- Hyponatremia, Hypernatremia, Postoperative Care in Neonates, Edema
- Trial name
- NCT06484608
- Testing
- Isotonic Saline with Dextrose
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Chronic Kidney Diseases, Dialysis; Complications
Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI
Chronic kidney disease (CKD) is prevalent worldwide and affects around 10% of people living in developed health economies. As the kidney loses its function in patients with CKD, the kidneys are unable to filter toxins out of the…
- Conditions
- Chronic Kidney Diseases, Dialysis; Complications, Sodium Retention
- Trial name
- NCT04848636
- Testing
- Cardiac Sodium and Proton MRI
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Head Trauma
Early Induced Hypernatremia for the Prevention and Management of Brain Edema
The purpose of this study is to estimate the effect of an early induced hypernatremia protocol (150-155 milliequivalent/L) versus normonatremia plus mannitol (135 - 145 milliequivalent/L) in terms of neurologic outcome in…
- Trial name
- EHIBE (NCT02798601)
- Testing
- Hypernatremia
- Sponsor
- Hospital Pablo Tobón Uribe
Respiratory Failure, Volume Overload
Stop Hypernatremia, Use Metolazone, for Aggressive, Controlled, Effective Diuresis
Patients who are on mechanical ventilation in an intensive care unit often require diursis as part of their pre-extubation regimen. The drug of choice for diuresis has traditionally been furosemide.
- Conditions
- Respiratory Failure, Volume Overload, Hypernatremia
- Trial name
- SHUM (NCT01617798)
- Testing
- Supplemental metolazone diuresis
- Where
- United States
- Sponsor
- Oregon Health and Science University
Sodium Excess, Racial Disparities
Vascular Effects of Acute Sodium (VEAS) Study
This IRB will cover a current clinical trial (NCT04244604) that was started at Auburn University (AU IRB#19-390), the Principal Investigator's prior institution, and is supported by his NIH Career Development Award (NHLBI…
- Conditions
- Sodium Excess, Racial Disparities, Blood Pressure, Cardiovascular Risk Factor
- Trial name
- NCT04244604
- Testing
- Low Sodium Meal (140 mg sodium chloride), High Sodium Meal (2500 mg sodium chloride)
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Nutrition, Culinary Medicine
Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention
Food Intake Study: This will be a 4-week randomized controlled intervention study with a vegetable intake questionnaire, daily food intake, and seasoning usage measurement to test the acceptability of different seasoning…
- Conditions
- Healthy Nutrition, Culinary Medicine, Sodium Excess
- Trial name
- NCT05591612
- Testing
- Salt replacement seasoning (50% salt and 50% MSG) mix, Salt replacement seasoning (70% salt and 30% MSG) mix, NaCl (sodium chloride/table salt)
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
The Patients Suffered With Sellar Diseases, The Fluid and Electrolyte Imbalance Happened After Surgery
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions.
- Trial name
- NCT01406041
- Testing
- Chemical and physical detection
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Southern Medical University, China
Healthy Adult Volunteers
Metabolism of Isotonic Versus Hypotonic Maintenance Solutions in Fasting Healthy Adults
The prescription of intravenous maintenance solutions - although widespread - lacks important data on the optimal sodium and potassium content, which has given rise to an important debate in the scientific literature.
- Trial name
- MIHMoSA (NCT02822898)
- Testing
- NaCl 0.9% in Glucose 5% with 40mEq Potassium, Glucion 5%
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Hypernatremia, Dehydration
Relieve the Patient's Thirst, Refresh the Mouth First (ICU-MIC)
Thirst is considered as one of the most distressing symptoms experienced by patients hospitalized in the Intensive Care Unit (ICU).
- Trial name
- ICU-MIC (NCT03610074)
- Testing
- Mint Ice Cube, Blood test, Patient's questioning
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Arras
Thoracic Diseases, Water-Electrolyte Imbalance
TOnicity of Perioperative Maintenance SoluTions
Prospective randomized double blind phase IV trial studying the efficacy and safety of the tonicity of two different perioperative maintenance solutions: an isotonic solution containing NaCl 0.9 in glucose 5% with an added 40…
- Conditions
- Thoracic Diseases, Water-Electrolyte Imbalance, Fluid Overload, Fluid Retention
- Trial name
- TOPMAST-1 (NCT03080831)
- Testing
- NaCl 0.9% in Glucose 5% + 40mmol/L Potassium, Glucion 5%
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Niels Van Regenmortel
Heart Failure, Congestive Heart Failure
Alfapump Direct Sodium Removal (DSR) Feasibility Study
First in Human feasibility and sfafety study of the alfapump DSR system in the treatment of Heart failure subects resistant to diuretic therapy.
- Conditions
- Heart Failure, Congestive Heart Failure, Cardiorenal Syndrome, Volume Overload
- Trial name
- RED DESERT (NCT04116034)
- Testing
- alfapump DSR system
- Where
- 2 sites in Belgium, Georgia
- Volunteers
- 8 people
- Sponsor
- Sequana Medical N.V.
Fluid Retention, Fluid Loss
The Effect of AMP Human Sodium Bicarbonate Lotion on Hydration
The purpose of this research study is to evaluate the effects of a topical sodium bicarbonate lotion on physiological and psychological responses associated with hydration status and fluid balance in humans during passive heat…
- Conditions
- Fluid Retention, Fluid Loss, Sodium Retention, Cognitive Change
- Trial name
- AMPlify (NCT04598386)
- Testing
- PR Lotion - AMP Human Performance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Sodium Excess, Cardiovascular Risk Factor
A Short, Animated Storytelling Video to Increase Knowledge About Sodium Intake as a Cardiovascular Risk Factor
This study will evaluate the effect of a short, animated storytelling intervention video on sodium intake as a major risk factor for cardiovascular disease on immediate and medium-term retention of knowledge about the risks of…
- Conditions
- Sodium Excess, Cardiovascular Risk Factor, Education Entertainment Intervention, Short, Animated Storytelling
- Trial name
- NCT05735457
- Testing
- A short, animated storytelling video on dietary sodium
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Hypernatremia
Investigation on Differences in Skin Sodium Content Between Normal Subjects and ICU-patients
This study investigates the differens in sodium storage in skin between normal subjects, patients after cardiac surgery and septic patients.
- Trial name
- InCa (NCT02912299)
- Testing
- Skin biopsies, Blood and urine analysis, Blood collection for RNA-investigation
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Frisius Medisch Centrum
Echinococcosis, Hepatic
Hypernatremia in Hydatid Cyst Treatment
Hypertonic saline (HS) is one of the most widely used scolocidal agents in the treatment of hydatid cysts. Hypernatremia is one of the complications associated with the use of HS.
- Trial name
- NCT05090020
- Testing
- Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Diabetes Type 2, Weight Gain
Effects of Insulin Detemir and NPH Insulin on Renal Handling of Sodium, Fluid Retention, and Weight in Type 2 Diabetic Patients
Hypothesis: Changing type 2 patients treatment from Insulin Insulatard to Insulin Detemir will increase their excretion of sodium in the urine and thereby decrease their extracellular volume and body weight.
- Trial name
- Le-Na (NCT00742976)
- Testing
- Insulin Detemir; Insulin Insulatard, Insulin Detemir, Insulin Insulatard
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Newborn Complication, Hyponatremia of Newborn
Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
Considering the physiological changes in fluid and electrolyte balance and providing proper support are one of the important aspects of neonatal intensive care.
- Conditions
- Newborn Complication, Hyponatremia of Newborn, Hypernatremia of Newborn, Fluid Therapy
- Trial name
- NEOFLUID (NCT04781361)
- Testing
- Intravenous isotonic fluid - NaCl 131-154 mmol/L in 5% dextrose, Intravenous Hypotonic fluid- Sodium Chloride < 130 mmol/L
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Dokuz Eylul University
Hypokalemia, Hyponatremia
Intravenous Fluids in Hospitalised Children
The main objective of the trial is to evaluate the risk of hypokalemia following administration of a isotonic solution compared to a hypotonic solution in acutely ill hospitalised children, who need intravenous fluid therapy.
- Conditions
- Hypokalemia, Hyponatremia, Hypernatremia, Dehydration
- Trial name
- NCT02926989
- Testing
- Plasmalyte Glucos 50 mg/mL, 0.45% saline in 5% dextrose
- Where
- Finland
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Oulu