Clinical trials: Soft Tissue Cancer
Cancer, Toxicity Due to Chemotherapy
Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer
The purpose of this study is to determine the efficacy of a temporary ovarian suppression obtained by administration of a gonadotropin releasing hormone agonist during alkylating agents containing chemotherapy on ovarian reserve…
- Conditions
- Cancer, Toxicity Due to Chemotherapy, Sarcoma, Osteosarcoma
- Trial name
- PRESOV (NCT02856048)
- Testing
- Triptorelin (GnRHa) + Chemotherapy
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metastatic Sarcoma, Recurrent Sarcoma
Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma
This early phase I trial studies the side effects of implanting and removing a microdevice in patients with sarcomas that have spread to other places in the body (metastatic) or have come back (recurrent).
- Conditions
- Metastatic Sarcoma, Recurrent Sarcoma, Resectable Sarcoma
- Trial name
- NCT04199026
- Testing
- Doxorubicin, Doxorubicin Hydrochloride, Drug Delivery Microdevice
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Refractory Malignant Solid Neoplasm, Osteosarcoma
AOH1996 for the Treatment of Refractory Solid Tumors
This phase I trial studies the side effects and best dose of AOH1996 in treating patients with solid tumors that do not respond to treatment (refractory).
- Conditions
- Refractory Malignant Solid Neoplasm, Osteosarcoma, Leiomyosarcomas, Synovial Sarcomas
- Trial name
- NCT05227326
- Testing
- PCNA Inhibitor AOH1996
- Where
- 3 sites in United States
- Volunteers
- 92 people
- Sponsor
- City of Hope Medical Center
Soft Tissue Sarcoma
Efficacy and Safety of Envafolimab Plus Doxorubicin and Ifosfamide for Advanced Soft Tissue Sarcoma
Soft tissue sarcoma (STS) is a rare, highly heterogeneous malignancy with a poor prognosis. The standard first-line treatment for advanced patients is anthracyclines (doxorubicin, A) combined with ifosfamide (I, AI regimen), but…
- Trial name
- NCT07243626
- Testing
- Envafolimab combined with an AI regimen (doxorubicin and ifosfamide)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Leiomyosarcoma
A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)
This study will compare the efficacy and safety of unesbulin plus dacarbazine versus placebo plus dacarbazine in participants with unresectable or metastatic, relapsed or refractory LMS who have received at least 1 prior line of…
- Trial name
- SUNRISELMS (NCT05269355)
- Testing
- Unesbulin, Dacarbazine
- Where
- 54 sites in United States, Australia and 10 more
- Volunteers
- 359 people
- Sponsor
- PTC Therapeutics
Sarcoma, Soft Tissue, Osteosarcoma
Eltrombopag for the Prevention of Chemotherapy Induced Thrombocytopenia
The purpose of this study is to study the effect of eltrombopag on chemotherapy induced thrombocytopenia. Thrombocytopenia is when there is a low number of platelets in the blood.
- Conditions
- Sarcoma, Soft Tissue, Osteosarcoma, Neoplasms, Connective and Soft Tissue
- Trial name
- NCT01491594
- Testing
- Eltrombopag
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma
This is a multicenter open-label, randomized, non-comparative, parallel cohort pivotal study of treatment with envafolimab (cohort A and C) or envafolimab combined with ipilimumab (cohort B and D) in patients with locally…
- Trial name
- ENVASARC (NCT04480502)
- Testing
- Envafolimab, Ipilimumab
- Where
- 30 sites in United States, United Kingdom
- Volunteers
- 207 people
- Sponsor
- Tracon Pharmaceuticals Inc.
Osteoma, Osteoid
Non-invasive Focal Therapy for Osteoid Osteoma
Non-invasive treatment of Osteoid osteoma using MRI guided high-intensity focused ultrasound. This study is designed as an intention-to-treat using a totally non-invasive approach for pain reduction, quality of life improvement…
- Trial name
- NCT02302651
- Testing
- MR guided High Intensity focused ultrasound
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Advanced Melanoma, Melanoma Metastatic
NY-ESO-1-redirected T Cells in Patients With Advanced Melanoma and Sarcoma
A single center, dose escalaion, Phase I clinical trial to demonstrate safety and efficacy of LauT-1, autologous "New York Esophageal Squamous Cell Carcinoma-1 T-Cell Receptor (NY-ESO-1 TCR)-directed T cells in combination with…
- Conditions
- Advanced Melanoma, Melanoma Metastatic, Sarcoma
- Trial name
- LauT1 (NCT06889766)
- Testing
- NY-ESO-1 TCR redirected autologous T cell product, Low-dose irradiation, Non-myeloablative lymphodepleting chemotherapy
- Where
- 2 sites in Switzerland
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cervical Cancer, Fallopian Tube Cancer
Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors
RATIONALE: Immunotoxins can locate tumor cells and kill them without harming normal cells. Immunotoxin therapy may be effective in treating advanced solid tumors.
- Conditions
- Cervical Cancer, Fallopian Tube Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00066651
- Testing
- SS1(dsFv)-PE38 immunotoxin
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Breast Fibroadenoma
High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma
This study is a multicentre, open, uncontrolled trial for the observation of histological changes in breast fibroadenoma following high intensity focused ultrasound (HIFU).
- Trial name
- NCT01422629
- Testing
- Ultrasonic ablation device
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Theraclion
Osteosarcoma
Mifamurtide (L-MTP-PE) for High-Risk Osteosarcoma
The purpose of this study was to collect information regarding the safety and tolerability of mifamurtide (liposomal muramyl tripeptide phosphatidyl ethanolamine; L-MTP-PE).
- Trial name
- NCT00631631
- Testing
- Mifamurtide (L-MTP-PE)
- Where
- 2 sites in United States
- Volunteers
- 205 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Soft Tissue Sarcoma
Ipilimumab + Nivolumab + Cryotherapy in Metastatic or Locally Advanced Soft Tissue Sarcoma
The purpose of this Phase 2 study is to 1. find out if the study drugs (ipilimumab plus nivolumab) in combination with cryotherapy will help participants with metastatic or locally advanced soft tissue sarcoma;. 2.
- Trial name
- NCT04118166
- Testing
- Ipilimumab, Cryoablation, Nivolumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kristen Ganjoo
Dermatofibrosarcomas of DARIER FERRAND(DFSP)
Phase II Pazopanib Study in Advanced Dermatofibrosarcomas
In relation to the activation of PDGF-mediated signalization due to the fusion gene COL1A1-PDGFb in DFSP, imatinib (800mg/day) has shown activity in advanced DFSP and has became the reference treatment option for these patients.
- Trial name
- DFSP-PAZO (NCT01059656)
- Testing
- Pazopanib
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Uterine Fibroid, Uterine Sarcoma
Radiomics-Based Non-Invasive MRI Differentiation of Uterine Sarcomas and Fibroids
This retrospective case-control study aims to develop and validate a diagnostic model based on multimodal big data and artificial intelligence to differentiate uterine leiomyoma from uterine sarcoma.
- Conditions
- Uterine Fibroid, Uterine Sarcoma, Diagnose Disease, AI (Artificial Intelligence)
- Trial name
- NCT07129005
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Tongji Hospital
Soft Tissue Sarcoma
Fruquintinib in the Treatment of Soft Tissue Sarcoma
To evaluate the efficacy of Fruquintinib in patients with chemotherapy insensitive or chemotherapy resistant soft tissue sarcoma
- Trial name
- NCT05142631
- Testing
- Fruquintinib
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Fudan University
Osteosarcoma
Assessing Clinical Trial Experiences of Patients With Osteosarcoma
Clinical study participation has historically been heavily biased toward specific demographics. Several people will be invited to enroll in this study so that it may collect a variety of data about osteosarcoma clinical trial…
- Trial name
- NCT05535283
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Epithelioid Hemangioendothelioma, Sarcoma,Soft Tissue
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
Epithelioid hemangioendothelioma (EHE) is an ultra-rare sarcoma, marked by distinctive molecular and pathological features and with a variable clinical behavior.
- Trial name
- EHE (NCT06408441)
- Where
- 22 sites in Austria, Denmark and 8 more
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Gastrointestinal Stromal Tumors
Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal Tumors
This trial was a Phase I/II, non-randomized, open label, multi-center study, following a sequential 2-part design.
- Trial name
- NCT01275222
- Testing
- RAD001, Imatinib 600mg/day (Glevec is the brand name for imatinib), Imatinib 800mg/day (Glevec is the brand name for imatinib)
- Where
- 16 sites in United States, Belgium and 2 more
- Volunteers
- 117 people
- Sponsor
- Novartis Pharmaceuticals
Leiomyoma
Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914
This study will evaluate whether the experimental drug ulipristal acetate can shrink uterine fibroids in pre-menopausal women.
- Trial name
- NCT00290251
- Testing
- ulipristal acetate 20 mg, ulipristal acetate 10 mg
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)