Clinical trials: Soft Tissue Sarcoma of the Limb
Soft Tissue Sarcoma of the Extremities
Predicting Radiotherapy Response and Toxicities in Soft Tissue Sarcoma of the Extremities - Cohort B
This is a multicentre prospective cohort study, primarily aimed at reporting the frequency and intensity of radiotherapy side-effects of patients with soft tissues sarcoma of the extremities (STSE).
- Trial name
- PredicT-B (NCT05978024)
- Where
- 3 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Osteosarcoma
Upfront Surgical Resection for Osteosarcoma
The goal of this pilot study is to learn about patients with newly diagnosed osteosarcoma of an extremity, and whether surgically removing the tumor prior to the administration of any chemotherapy will improve functional…
- Trial name
- UFSR for OS (NCT06384404)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Montefiore Medical Center
Recurrent Adult Soft Tissue Sarcoma, Stage I Adult Soft Tissue Sarcoma AJCC v7
Preoperative Thalidomide With Radiation Therapy For Patients With Low-Grade Primary Soft Tissue Sarcoma or Thalidomide With Radiation Therapy and Chemotherapy For Patients With High-Grade or Intermediate-Grade Primary Soft Tissue Sarcoma of the Arm, Leg, or Body Wall
Thalidomide may stop the growth of soft tissue sarcoma by stopping blood flow to the tumor. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Recurrent Adult Soft Tissue Sarcoma, Stage I Adult Soft Tissue Sarcoma AJCC v7, Stage II Adult Soft Tissue Sarcoma AJCC v7, Stage III Adult Soft Tissue Sarcoma AJCC v7
- Trial name
- NCT00089544
- Testing
- Dacarbazine, Doxorubicin Hydrochloride, Filgrastim
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Cancer Institute (NCI)
Osteosarcoma, Ewing's Sarcoma
Effects of Preoperative Physical Therapy in Patients With Lower Extremity Malignancy
This application proposes a prospective clinical trial to evaluate the impact of adding a focused physical therapy (PT) intervention to the preoperative regimen of individuals diagnosed with a malignancy of the lower extremity…
- Conditions
- Osteosarcoma, Ewing's Sarcoma, Rhabdomyosarcoma, Synovial Sarcoma
- Trial name
- NCT01674101
- Testing
- Endurance, Strengthening, Stretching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Jude Children's Research Hospital
Soft Tissue Sarcoma of the Trunk and Extremities
Surgical Timing After Preoperative Hypofractionated Radiotherapy for Localized Extremity and Trunk Soft Tissue Sarcoma
Phase II, national, multicentric, prospective, randomized (1:1) non-inferiority trial with two parallel groups, incorporating a concurrent observational cohort of eligible non-randomized patients, designed to address critical…
- Trial name
- STARS (NCT07265661)
- Testing
- hypofractionated radiotherapy (30Gy/5 fractions) and surgical resection at 1-2 weeks after treatment, hypofractionated radiotherapy (30Gy/5 fractions) and surgical resection at 4-6 weeks after treatment
- Volunteers
- 142 people
- Sponsor
- Italian Sarcoma Group
Soft Tissue Sarcoma
Study of Low Dose CT in Sarcoma Patients
The primary outcome of this study is the detection of lung metastases comparing Low dose CT (LDCT) and Minimum dose CT (MnDCT) with CXR. Hypothesis 1.
- Trial name
- NCT00188422
- Testing
- low dose CT
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Sarcoma, Sarcoma,Soft Tissue
Preventive Application of Single-use Negative Pressure Wound Therapy (sNPWT) in the Postoperative Course of Radiotreatated Limb Sarcoma Surgery
Patients will be recruited at the time of the pre-admission visit. During the screening visit the patient will undergo a physical examination and his medical history will be collected.
- Trial name
- PRALISS (NCT06941194)
- Testing
- PICO 14
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Sarcoma,Soft Tissue
Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities
Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017.
- Trial name
- MFS (NCT04991883)
- Testing
- case series review of clinical and histological data
- Where
- Italy
- Volunteers
- 167 people
- Sponsor
- Istituto Ortopedico Rizzoli
Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma (Excluding GIST)
Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall
This trial aims to assess the long-term efficacy of moderately hypofractionated neoadjuvant radiotherapy for soft tissue sarcoma in the limbs or trunk wall.
- Conditions
- Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma of the Trunk and Extremities, Soft Tissue Sarcoma of the Limb
- Trial name
- NEORASARC (NCT07507773)
- Testing
- Moderately hypofractionated neoadjuvant radiotherapy
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Centre Oscar Lambret
Sarcoma, Soft Tissue Sarcoma
Wide Excision of Soft Tissue Sarcomas in Combination With Interstitial Radiation Therapy
Intraoperatively, in the bed of the removed tumor, a surgical mesh is sutured onto which the intrastats are fixed. On days 2-3, topometric preparation is carried out, the choice of the amount of irradiation, the calculation of…
- Trial name
- NCT05057195
- Testing
- Interstitial radiation therapy, Postoperative external beam therapy
- Where
- Russia
- Volunteers
- 78 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Soft Tissue Sarcomas
The Total Neoadjuvant Therapy for Soft Tissue Sarcoma of the Extremities
For localized soft tissue sarcomas (STS) of the extremities, limb-sparing or conservative surgery with perioperative radiotherapy (RT) is the standard of care. However, several challenges persist.
- Trial name
- NCT06593899
- Testing
- Hypofractionated Radiotherapy, 3 cycles of AI
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Fujian Medical University Union Hospital
Sarcoma
Chemotherapy Plus Radiation Therapy Followed by Surgery in Treating Patients With Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002791
- Testing
- filgrastim, dacarbazine, doxorubicin hydrochloride
- Where
- 237 sites in United States, Canada and 1 more
- Sponsor
- Radiation Therapy Oncology Group
Soft Tissue Sarcoma
Trial of Neoadjuvant Conformal Radiotherapy Plus Sorafenib for Patients With Soft Tissue Sarcoma of the Extremity and Body Wall
Patients will receive neoadjuvant sorafenib (investigational agent) in combination with preoperative external beam conformal radiotherapy (50 Gy in 25 fractions) for localized, large soft tissue sarcomas of the extremity and body…
- Trial name
- NCT00864032
- Testing
- Sorafenib
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Davis
Soft Tissue Sarcoma of the Extremities
Proton Radiotherapy for Extremity Soft Tissue Sarcoma
This is a study of proton radiotherapy for the pre- or post- operative treatment of patients with extremity sarcoma. This study will treat patients in two dose groups: 1. patients receiving pre-operative proton therapy and 2.
- Trial name
- NCT01561495
- Testing
- Proton Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Osteosarcoma, Analgesia
Efficacy of Epidural Analgesia in Lower Extremity Osteosarcoma
In this study, the investigators aim to reduce complications in orthopedic malignancy surgeries and to increase the quality of life of patients who will be operated on.
- Trial name
- NCT04945512
- Testing
- Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Istanbul University
Sarcoma, Microwave
The Safety and Efficacy of Combined Microwave Ablation During Limb-sparing Surgery in High-risk Soft Tissue Sarcoma Patients
Soft tissue sarcoma (STS) is a rare, aggressive malignancy with a high risk of recurrence when invading surrounding structures, and the optimal treatment strategy for safe surgical margin is still unclear.
- Conditions
- Sarcoma, Microwave, Ablation Techniques
- Trial name
- NCT06802510
- Testing
- Microwave Ablation
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Guangdong Provincial People's Hospital
Sarcoma, Sarcoma, Leiomyo-, Adult
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
This is a cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT) in high-risk soft tissue sarcoma (STS) patients with dedifferentiated liposarcoma (DDLPS), leiomyosarcoma…
- Conditions
- Sarcoma, Sarcoma, Leiomyo-, Adult, Sarcoma, Synovial, Adult, Soft Tissue Sarcoma (STS)
- Trial name
- PANTHR-S (NCT07432932)
- Testing
- Observational Translational Study
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Stage IVB Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma
Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Infusing melphalan directly to the tumor may kill more tumor cells and cause less damage to healthy tissues.
- Conditions
- Stage IVB Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma, Stage IIC Adult Soft Tissue Sarcoma, Recurrent Adult Soft Tissue Sarcoma
- Trial name
- NCT00019968
- Testing
- melphalan, tumor necrosis factor
- Sponsor
- National Institutes of Health Clinical Center (CC)
Osteosarcoma
Donor Site Morbidity After Free Vascularized Fibular Graft
This study was carried out at Assiut University to Asses the long-term donor site morbidity following free vascularized fibular transfer because there is a limited information regarding the long-term donor morbidity of this type…
- Trial name
- NCT06324916
- Testing
- Xray
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult
Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma.
The purpose of the study is to study if dose escalated proton radiotherapy can improve local controll for patients with inoperable soft tissue sarcomas. The standard treatment is photon-based radiation.
- Conditions
- Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma of the Trunk and Extremities, Synovial Sarcomas
- Trial name
- PROSARC-2 (NCT07173972)
- Testing
- Definitive radiotherapy
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital