Clinical trials: Soil-Transmitted Helminthiasis
Soil Transmitted Helminths, Schistosomiasis Mansoni
Evaluation of an AI-DP for STH Deworming Programs: a Study Protocol
The goal of this observational study is to test a new AI diagnostic tool for detection, specification and quantification of parasitic infections (Ascaris, Trichuris, hookworm and S.
- Trial name
- KAKADU (NCT06055530)
- Testing
- Artificial Intelligence Digital Pathology
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Enaiblers AB
Ascaris Lumbricoides, Ascaris Suum
Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2
Objectives: The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted Helminths (STH). The primary objective is: (1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against…
- Conditions
- Ascaris Lumbricoides, Ascaris Suum, Trichuris Trichiura, Trichuris Vulpis
- Trial name
- ConWorm (NCT01379326)
- Testing
- Mebendazole
- Where
- 9 sites in Argentina, Australia and 6 more
- Volunteers
- 250 people
- Sponsor
- University Ghent
Healthy
Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren
Considering the facts that: (i) IPT of malaria provides substantial protection against anaemia and malaria in school children (ii); SP resistance has no significant impact on the prophylactic efficacy (iii) SP-PQ is safe and as…
- Trial name
- PIP-IPT (NCT01722539)
- Testing
- Sulfadoxine-pyrimethamine, Piperaquine, Albendazole
- Where
- Republic of the Congo
- Volunteers
- 616 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Soil-transmitted Helminth Infections
Community Health Education and Hygiene Promotion Added to Deworming Among Ethnic Khmer Children in Vietnam
This study evaluated whether adding community health education and household hygiene promotion to supervised deworming could improve soil-transmitted helminth (STH) outcomes and related caregiver and household factors among…
- Trial name
- NCT07855978
- Testing
- Albendazole 400 mg, Community Health Education and Hygiene Promotion
- Where
- 4 sites in Vietnam
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant
This study is designed to evaluate the safety, reactogenicity, and immunogenicity of Na-GST-1 adsorbed to Alhydrogel® with or without two different dose concentrations of a novel adjuvant, GLA-AF (1 µg or 5 μg) among healthy…
- Trial name
- NCT01385189
- Testing
- 10 μg Na-GST-1/Alhydrogel, 30 μg Na-GST-1/Alhydrogel, 100 μg Na-GST-1/Alhydrogel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Soil Transmitted Helminth (STH) Infections
Assessing the Safety and Efficacy of a Combination Therapy for STH in PSAC in Bangladesh
Background (brief): 1. Burden: Soil-transmitted helminth (STH) infections are a major public health problem, primarily affecting children.
- Trial name
- NCT07045493
- Testing
- A single dose of Albendazole 400mg + Ivermectin (200 µg/ kg) combination therapy, A single dose of 400 mg Oral Albendazole monotherapy
- Where
- Bangladesh
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Helminthiasis, Ascaris Infection
Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education
Soil-transmitted helminth (STH) infections caused by Ascaris lumbricoides, Trichuris trichiura, or hookworm, affect approximately 1.5 millions individuals primarily in tropical and subtropical regions.
- Conditions
- Helminthiasis, Ascaris Infection, Trichuris Infection, Hookworm Infections
- Trial name
- NCT04227834
- Testing
- Health hygiene education
- Where
- Indonesia
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara
Helminthiasis
Assessment of Drug Efficacy of Local Albendazole
Infections with soil-transmitted helminthes (STH) occur throughout the developing world and remain a major public health problem in the poorest communities.
- Trial name
- NCT02420574
- Testing
- albendazole BENDEX, albendazole OVIS
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- University Ghent
Healthy
Safety, Tolerability and PK of Single and Multiple Doses of Oxantel Pamoate Tablets
The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics of oxantel pamoate tablet after administration of a single and multiple dose in healthy male and female adult volunteers.
- Trial name
- HELP-OXA (NCT06606860)
- Testing
- Oxantel Pamoate
- Where
- Tanzania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections
Burden of Schistosomiasis and Soil-transmitted Helminth Infections in Schoolchildren in Banfora, Burkina Faso
A cross-sectional study will be conducted among 300 schoolchildren in the Banfora region, including 120 in urban and 180 in rural areas, to assess the prevalence of schistosomiasis and soil-transmitted helminth infections.
- Conditions
- Schistosomiasis in Children, Soil Transmitted Helminth (STH) Infections, Malaria Infection, Anaemia
- Trial name
- NTDs_SAC (NCT06973200)
- Testing
- Dihydroartemisin-piperaquine
- Where
- Burkina Faso
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Centre MURAZ/Institut National de Santé Publique
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
Intestinal Parasitic Infections, Knowledge, Attitudes, Practice
Impact of Health Education Learning Package Against Intestinal Parasitic Infections Among Orang Asli Children
A health education learning package (HELP) has been improved and evaluated for its impact against intestinal parasitic infections among Orang Asli schoolchildren in West Malaysia.
- Trial name
- NCT03930901
- Testing
- Health education learning package
- Where
- Malaysia
- Volunteers
- 1,142 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Ascariasis, Trichuriasis
Efficacy Albendazole and Levamisole Against STH on Unguja
Field epidemiological studies undertaken during 2005 in four village locations in Northern Unguja, Zanzibar examined mothers and their pre-school aged children for helminth infections.
- Trial name
- ALBvLEV (NCT00659997)
- Testing
- Albendazole, Levamisole
- Where
- Tanzania
- Volunteers
- 20 people
- Sponsor
- Natural History Museum, United Kingdom
Soil-transmitted Helminth Infection, Onchocerciasis (River Blindness)
A Study to Learn About How Much Emodepside Gets Absorbed in the Blood and How Food Affects Its Absorption When Given as a New Type of Tablet to Healthy Participants
Onchocerciasis or river blindness is an infectious disease caused by a parasitic worm. It spreads through the bite of an infected blackfly.
- Trial name
- NCT06412926
- Testing
- BAY 44-4400
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Malaria, Soil Transmitted Helminths
Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children
Malaria remains a major health problem, especially in sub-Saharan Africa where more than 90% of the disease and deaths occur in children.
- Conditions
- Malaria, Soil Transmitted Helminths, Schistosomiasis, Integrated Control
- Trial name
- MALHELMIN (NCT05354258)
- Testing
- Albendazole, Praziquantel, Amodiaquine
- Where
- Senegal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity Study of Na-GST-1 With or Without CpG
Na-GST-1 is a protein expressed during the adult stage of the hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02143518
- Testing
- Na-GST-1/Alhydrogel®, CpG 10104
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Lymphatic Filariasis, Onchocerciasis
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
Approximately 4,000 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis and onchocerciasis endemic areas.
- Conditions
- Lymphatic Filariasis, Onchocerciasis, Soil Transmitted Helminth (STH) Infections
- Trial name
- NCT02032043
- Testing
- Annual versus Semiannual Albendazole plus Ivermectin MDA
- Where
- Côte d’Ivoire
- Volunteers
- 14,457 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Helminth Infections
A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants
The purpose of this study is to evaluate the efficacy and safety of mebendazole compared with placebo in pediatric participants with Helminth infections.
- Trial name
- NCT02034162
- Testing
- Mebendazole
- Where
- 3 sites in Ethiopia, Rwanda
- Volunteers
- 295 people
- Sponsor
- Janssen Research & Development, LLC
Anemia, Antenatal Care
Effects of Video-based Health Education on Maternal and Child Health in Ethiopia
Low adherence to recommended health and nutrition strategies during the critical 1000 day-window of opportunity is multifactorial but low quality communication is key limitation.
- Conditions
- Anemia, Antenatal Care, Birth Outcomes, Worm Infection
- Trial name
- MCH (NCT04414527)
- Testing
- Standard counselling, Health-Video
- Where
- Ethiopia
- Volunteers
- 675 people
- Sponsor
- University Ghent