Clinical trials: Solid Malignancy
Malignant Brain Neoplasm, Malignant Solid Neoplasm
Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases
This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers).
- Conditions
- Malignant Brain Neoplasm, Malignant Solid Neoplasm, Multiple Sclerosis, Neuroendocrine Tumor
- Trial name
- NCT06788886
- Testing
- Biospecimen Collection, Exercise Intervention, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Advanced Malignant Solid Neoplasm
Group Meaning-Centered Psychotherapy for the Improvement of Wellbeing in Caregivers of Patients With Serious Illness
This clinical trial assesses the acceptability and feasibility of a virtual group Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C) and its effect in improving the wellbeing of caregivers of patients with advanced…
- Trial name
- NCT06630351
- Testing
- Behavioral Counseling, Discussion, Health Promotion and Education
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Geriatric Assessment Screening Tool for the Identification of At-Risk Older Adults Who Are Undergoing Cancer Treatment
This phase II trial investigates how easy it is to incorporate a nursing led geriatric assessment screening tool into a busy oncology practice, in order to identify at-risk older adults being evaluated for cancer treatment.
- Trial name
- NCT04788758
- Testing
- Educational Intervention, Screening Questionnaire Administration, Referral
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm
Parenting Support Intervention for Families Coping With Metastatic or Locally Recurrent Solid Tumor Diagnosis
This clinical trial examines the acceptability and effect of a parenting support intervention for families coping with solid tumor that has spread to other places in the body (metastatic) or has come back (recurrent).
- Trial name
- NCT05059678
- Testing
- Best Practice, Educational Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Unspecified Adult Solid Tumor, Protocol Specific
Green Tea Extract (Polyphenon E) in Preventing Cancer in Healthy Participants
RATIONALE: Green tea extract (Polyphenon E) contains ingredients that may prevent the development of cancer. PURPOSE: This phase I trial is studying how well green tea extract works in preventing cancer in healthy participants.
- Trial name
- NCT00091325
- Testing
- defined green tea catechin extract
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Solid Tumor, Adult
Improving Cyberknife Spinal Stereotactic Radiotherapy in Difficult to Treat Cases (IMPRESS)
A prospective study evaluating prone and supine positioning for radiation planning of spine Cyberknife radiotherapy treatment. Patients with tumours in which PTV coverage is compromised due to tumour geography, including…
- Trial name
- IMPRESS (NCT05252975)
- Testing
- Setup and Imaging for at CT radiation planning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Royal Marsden NHS Foundation Trust
Solid Tumor Malignancies
ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
- Trial name
- NCT04668833
- Testing
- Autologous lymphocyte infusion (ALI)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Solid Neoplasm
Financial Navigation Program to Improve Understanding and Management of Financial Aspects of Cancer Care for Patients and Their Spouses
This clinical trial examines a financial navigation program in helping patients (and their spouses or partner caregivers, if participating) understand and better manage the financial aspects of cancer care.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm
- Trial name
- CREDIT (NCT04960787)
- Testing
- Educational Intervention, Patient Navigation, Quality-of-Life Assessment
- Where
- 266 sites in United States, Puerto Rico
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Solid Tumor, Pleural Effusion
Collection of Pleural Effusion Fluid
At the Laboratory for Molecular and Cellular Therapy (LMCT) of the Vrije Universiteit Brussel, Belgium, we study resistance mechanisms that hamper effective immunotherapy for solid cancer patients.
- Conditions
- Solid Tumor, Pleural Effusion, Metastasis
- Trial name
- NCT05539183
- Testing
- Blood withdrawal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Solid Tumor
An Bioequivalence Study to Compare 10mg & 20mg of Senaparib Capsules in Healthy Chinese Subjects Under Fasting Condition
An Open-label, Randomized, Single-dose, Two-way Crossover Bioequivalence Study to Compare Two Strengths (10 mg and 20 mg) of Senaparib Capsules in Healthy Chinese Subjects Following Oral Administration Under Fasting Condition
- Trial name
- NCT07019194
- Testing
- Senaparib capsules(20mg), Senaparib capsules(10mg)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Impact Therapeutics, Inc.
Bladder Carcinoma, Breast Carcinoma
The Vanguard Study: Testing a New Way to Screen for Cancer
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial.
- Conditions
- Bladder Carcinoma, Breast Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma
- Trial name
- NCT06995898
- Testing
- Biospecimen Collection, Device Usage, Electronic Health Record Review
- Where
- 45 sites in United States
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm
Evaluating a Mobile Health Application Intervention for Caregiver Instruction in Manual Therapy for Chemotherapy-Induced Peripheral Neuropathy
This clinical trial assesses the impact of a family caregiver-delivered massage technique for use in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN).
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
- Trial name
- NCT06945380
- Testing
- Best Practice, Comparator Program, Best Practice, Usual Care, Internet-Based Intervention
- Where
- United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Understanding Needs of Older Patients Prior to Starting Cancer Treatment
A geriatric assessment (GA) is a structured approach to identifying and addressing the strengths and vulnerabilities of older adults with cancer.
- Trial name
- PGA (NCT07225920)
- Testing
- Survey Administration, Interview, Educational Intervention
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Solid Tumours
Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers
To evaluate the absorption, distribution, metabolism and excretion (ADME) of single dose [14C] selumetinib in volunteers
- Trial name
- NCT01931761
- Testing
- [C14] selumetinib (oral)
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Solid Tumours
To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers
Study to assess the effect of Rifampicin on the pharmacokinetics of Selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in Healthy Male Volunteers
- Trial name
- NCT02046850
- Testing
- selumetinib, rifampicin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Refractory Solid Tumors, Lymphomas
A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval
This is a double-blind (vis-a-vis lenvatinib), randomized, placebo-controlled, three-treatment, three-way crossover study in healthy subjects. There are two phases in this study: Pre-Randomization and Randomization.
- Trial name
- NCT01525394
- Testing
- Lenvatinib, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Malignant Solid Neoplasm, Hematopoietic Neoplasms
Optimizing Health Related Quality of Life Measurement in Adolescent and Young Adult Oncology
This study evaluates how adolescent and young adults with cancer in the U.S. and their loved ones respond to questions that will later be used with people who may have cancer and other chronic health conditions
- Conditions
- Malignant Solid Neoplasm, Hematopoietic Neoplasms, Lymphatic System Neoplasm
- Trial name
- NCT06897137
- Testing
- Surveys/Questionnaires
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Horton's Disease, Infectious Disease
Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)
The aim of this open, controlled, multicentre biomedical research study is to identify new markers specifically associated with Horton's disease.
- Conditions
- Horton's Disease, Infectious Disease, Neoplasia, Solid Tumor
- Trial name
- NCT02065297
- Testing
- 1 blood sample, 2 to 3 blood samples (at inclusion, at 3 months and at 6 months in cases of relapse)
- Where
- 3 sites in France
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Stop Addiction Stigma
This clinical trial evaluates the impact of a Stop Addiction Stigma (SAS) training workshop with a short description of the conditions related to addiction (vignettes) on stigmatizing attitudes toward individuals with substance…
- Trial name
- NCT06582030
- Testing
- Assessment, Educational Activity, Training
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Advanced Solid Tumors
Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers
This is a double blind Phase I study to evaluate the safety, tolerability, and pharmacokinetics of escalating oral doses of DN1406131, an investigational agent intended to inhibit the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme…
- Trial name
- NCT03641794
- Testing
- DN1406131
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangxi Qingfeng Pharmaceutical Co. Ltd.