Clinical trials: Solid Tumours
Malignant Solid Tumors, Clear Cell Renal Cell Carcinoma
CAIX-targeted PET/CT in Solid Tumors
Tumor hypoxic microenvironment plays an important role in the initiation and progression of solid tumors, as well as tumor invasion, metastasis, and treatment resistance.
- Conditions
- Malignant Solid Tumors, Clear Cell Renal Cell Carcinoma, Lung Cancer (NSCLC), Breast Cancer
- Trial name
- CAIX-PET (NCT07833085)
- Testing
- 68Ga-CAIX
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Solid Tumours
Utility and Work Productivity Data for Economic Evaluation of Breast Cancer Therapies in the Netherlands and Sweden
Introduction: Many reimbursement authorities use economic evaluation to help guide decisions regarding the adoption of new treatments in reimbursement systems.
- Trial name
- NCT01209091
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer
This study uses ambient sensing rooms to collect data from hospitalized cancer patients in order to improve safety and recovery.
- Trial name
- NCT07477886
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer, Lung Cancer
Developing a Virtual Stress Management Intervention for Spousal/Partnered Caregivers of Solid Tumor Cancer Patients.
This randomized control trial will investigate the ability of an effective stress management psychoeducation program for employed caregivers to mitigate psychological distress and pathophysiology in spousal or partnered…
- Conditions
- Breast Cancer, Lung Cancer, Colon Cancer, Solid Tumor, Adult
- Trial name
- eCare (NCT04739696)
- Testing
- PEPRR, Pep-Pal
- Where
- United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Leukemia, Advanced Solid Tumor
Evaluation of Bibliotherapy by Students and Patients With Cancer
Research has demonstrated the positive effects of bibliotherapy (the use of reading in the treatment of patients), such as increased self-awareness, increased empathy, hope and decreased negativity.
- Trial name
- NCT03969082
- Testing
- Bibliotherapy
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Solid Tumor
BA Study of IMP4297 (20mg vs 10mg) in Healthy Male Subjects
An open-label, randomized, single-dose, 2-way crossover study to compare the bioavailability of two IMP4297 formulations (20 mg capsules and 10 mg capsules) after single oral administration of 100 mg IMP4297 under fasted…
- Trial name
- NCT04351165
- Testing
- IMP4297
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Impact Therapeutics, Inc.
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Evaluation of an Education Program to Increase Knowledge and Participation in Clinical Trials Among Racial/Ethnic and Rural Populations
This clinical trial evaluates a culturally tailored educational outreach intervention for increasing clinical trial knowledge, referral, and participation among racial/ethnic minority and rural populations.
- Trial name
- NCT06112002
- Testing
- Educational Intervention, Health Education, Survey Administration
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Non Small Cell Lung Cancer, Esophageal Cancer
Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery.
- Conditions
- Non Small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT03551951
- Testing
- Test for circulating tumor cells, DNA alterations
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Community Enhanced Virtual Informed Consent
The goal of this clinical trial is to examine perceptions of virtual human communicators and cancer research recruitment messages.
- Trial name
- CEVIC (NCT07805083)
- Testing
- Educational Cancer Intervention, ICF Text Version 1, ICF Text Version 2
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Advanced Solid Tumor
The Absorption, Metabolism and Excretion of [14C]CM082 in Human
This is a single-center, open-label, single-dose phase I study to investigate the absorption, metabolism and excretion of [14C] CM082 in healthy Chinese male subjects.
- Trial name
- NCT04434326
- Testing
- [14]CM082 suspension
- Where
- China
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- AnewPharma
Solid Tumors
A Study in Healthy Male Subjects to Understand How Savolitinib When Taken With Midazolam Behaves Inside the Body
This study will be an open label, 2 period, fixed sequence study in healthy male subjects, performed at a single study center in the Unites States of America.
- Trial name
- NCT04187456
- Testing
- Savolitinib, Midazolam
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cancer, Tumors
Detection of Tumor DNA in Blood Samples From Cancer Patients
The aim of this study is to employ genomic detection methodologies to measure the relative amount of tumor nucleic acids in the blood of a cancer patient with diagnosed metastatic disease that is either commencing, currently…
- Trial name
- NCT02288754
- Testing
- Blood test
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lexent Bio, Inc.
Refractory Solid Tumors, Lymphomas
A Double-Blind Study in Healthy Volunteers to Assess the Effect of E7080 on the QTc Interval
This is a double-blind (vis-a-vis lenvatinib), randomized, placebo-controlled, three-treatment, three-way crossover study in healthy subjects. There are two phases in this study: Pre-Randomization and Randomization.
- Trial name
- NCT01525394
- Testing
- Lenvatinib, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Solid Tumor
IMP4297 DDI (Drug-Drug Interaction)Trial in Healthy Male Volunteers
A Phase I, Open-label, Fixed-Sequence Study to Evaluate the Effect of Multiple-dose Itraconazole or Rifampicin Capsules on the Single-dose PK Profiles of IMP4297 Capsules in Healthy Subjects
- Trial name
- NCT04584515
- Testing
- IMP4297 40 mg, IMP4297 100 mg
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Impact Therapeutics, Inc.
Unspecified Adult Solid Tumor, Protocol Specific
Indole-3-Carbinol in Preventing Cancer in Healthy Participants
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of indole-3-carbinol may prevent cancer.
- Trial name
- NCT00100958
- Testing
- indole-3-carbinol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kansas
Unspecified Adult Solid Tumor, Protocol Specific
Internet-Based Nutrition Education Program in Preventing Cancer in Participants of Health Maintenance Organizations
RATIONALE: Websites for nutrition education may be an effective method to help people eat more fruits and vegetables which may lower their risk of cancer.
- Trial name
- NCT00169312
- Testing
- behavioral dietary intervention, dietary intervention, educational intervention
- Where
- 4 sites in United States
- Volunteers
- 2,619 people, healthy volunteers welcome
- Sponsor
- Josephine Ford Cancer Center
Advanced Malignant Solid Tumors
A Study to Investigate the Food Effect on the Pharmacokinetics of CM082 Tablet in Chinese Healthy Volunteers
The main objective of this study is to evaluate the Effect of Food on the Pharmacokinetics of CM082 tablet.
- Trial name
- NCT04126668
- Testing
- CM082 with fed or fasting
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AnewPharma
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Geriatric Assessment Screening Tool for the Identification of At-Risk Older Adults Who Are Undergoing Cancer Treatment
This phase II trial investigates how easy it is to incorporate a nursing led geriatric assessment screening tool into a busy oncology practice, in order to identify at-risk older adults being evaluated for cancer treatment.
- Trial name
- NCT04788758
- Testing
- Educational Intervention, Screening Questionnaire Administration, Referral
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Hepatic Impairment
Pharmacokinetics and Safety Study of Siremadlin (HDM201) in Participants With Mild, Moderate and Severe Hepatic Impairment
The main purpose of this study is to evaluate the effect of varying degrees of impaired hepatic function (by Child Pugh classification) on the plasma PK of siremadlin after a single oral dose.
- Trial name
- NCT05599932
- Testing
- Siremadlin
- Where
- 3 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Solid Tumor
A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers.
This study will evaluate the bioavailability, palatability, safety and tolerability of entrectinib in healthy volunteers. Part 1 of the study will explore the performance of entrectinib multi-particle formulation.
- Trial name
- NCT03961100
- Testing
- Entrectinib 600 mg (T1), Entrectinib 600 mg (T2), Entrectinib 200 mg (R)
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.