Clinical trials: Spastic Dysphonia
Laryngeal Dystonia
tDCS for Laryngeal Dystonia
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
- Trial name
- NCT06830174
- Testing
- Starstim system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Spasmodic Dysphonia
EMG-Guided Versus Endoscopic-Catheter Botulinum Toxin Injection for Spasmodic Dysphonia
This randomized, controlled non-inferiority trial will compare two established botulinum toxin injection techniques for adductor spasmodic dysphonia: percutaneous electromyography-guided injection and transnasal endoscopic…
- Trial name
- NCT07894172
- Testing
- Intervention A - Electromyography (EMG)-Guided BTX Injection, Intervention B - Endoscopic Catheter BTX Injection
- Volunteers
- 17 people
- Sponsor
- Chinese University of Hong Kong
Spasmodic Dysphonia, Quality of Life
Spasmodic Dysphonia Interviews
Previous research has shown that patients with voice disorders often have a lower quality of life and struggle with employment. Spasmodic Dysphonia (SD) is a voice disorder that causes abrupt and uncontrollable spasms of the…
- Trial name
- NCT06561334
- Testing
- Botulinum toxin injections
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Manchester University NHS Foundation Trust
Laryngeal Dystonia, Spasmodic Dysphonia
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
- Trial name
- NCT05150093
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Dystonia
The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias
Dystonia is a disorder characterized by excessive involuntary contraction of muscles with repetitive and patterned movements. The isolated dystonias are the most common type of dystonia and include Limb dystonias (like writer's…
- Trial name
- DCP (NCT01373424)
- Where
- 42 sites in United States, Australia and 5 more
- Volunteers
- 3,265 people
- Sponsor
- Emory University
Spasmodic Dysphonia, Laryngeal Dystonia
Thalamic Deep Brain Stimulation for Spasmodic Dysphonia- DEBUSSY Trial
Laryngeal Dystonia (LD), also commonly referred to as spasmodic dysphonia, is a neurological voice disorder characterized by involuntary dystonic contractions of the laryngeal muscles.
- Conditions
- Spasmodic Dysphonia, Laryngeal Dystonia, Deep Brain Stimulation
- Trial name
- NCT02558634
- Testing
- VIM Thalamic Deep Brain Stimulation ON, VIM Thalamic Deep Brain Stimulation OFF
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Adductor Spasmodic Dysphonia
The 'Lombard Effect' in Patients Affected by Adductor Laryngeal Dystonia
Adductory spasmodic dysphonia (AdSD) is a rare condition characterised by irregular and uncontrolled voice interruptions, most commonly affecting women around the age of 45.
- Trial name
- LoQVAdSD (NCT06402214)
- Testing
- Lombard test
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Phonation Disorder, Spastic Dysphonia
Sensory Function in Idiopathic Voice Disorders
This research study is designed to improve understanding about voice disorders that are due to uncontrolled muscle contractions affecting the voice box.
- Conditions
- Phonation Disorder, Spastic Dysphonia, Voice Disorder
- Trial name
- NCT00001922
- Where
- United States
- Volunteers
- 370 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Voice Disorders
Brain Mapping of Voice Control
Some voice disorders are caused by uncontrolled muscle actions that affect the larynx or voice box. The purpose of this study is to understand 1) how the brain controls voice production; 2) how changes in sensation within the…
- Trial name
- NCT00066911
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Spasmodic Dysphonia
Laryngeal Vibration for Spasmodic Dysphonia
The general aim of the research is to provide scientific evidence that vibro-tactile stimulation (VTS) represents a non-invasive form of neuromodulation that can induce measurable improvements in the speech of people with…
- Trial name
- SD-VTS (NCT03746509)
- Testing
- Laryngeal Vibration (Treatment), Laryngeal Vibration (Comparator)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Laryngeal Dystonia, Adductor Spastic Dysphonia of Dystonia
Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application
Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia…
- Trial name
- NCT05506085
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Spasmodic Dysphonia
A Phase 2 Trial of Deep Brain Stimulation for Spasmodic Dysphonia
Spasmodic Dysphonia (SD) is a focal, action-specific movement disorder with prominent effects on speech (1, 2). Patients with SD lose their ability to speak normally due to involuntary contractions of their laryngeal muscles.
- Trial name
- NCT04938154
- Testing
- DBS ON, DBS OFF
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of British Columbia
Adductor Spasmodic Dysphonia
The Effect of Vocal Rest Versus Vocalization Following Xeomin® Injections in Spasmodic Dysphonia
This study will compare the effects of vocal rest versus continuous vocalization for one hour immediately following botulinum toxin injections for adductor spasmodic dysphonia.
- Trial name
- NCT03129087
- Testing
- Vocal rest versus vocalization
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Vocal Fold Paresis, Laryngeal Dystonia
Monitoring of the Safety and the Performance of the Endoscopic Cap Electrode (ECE50)
The objective of this registry is to confirm the safety and the performance of the ECE50 in medical routine by collecting data.
- Trial name
- ECE50 (NCT05245942)
- Where
- Austria
- Volunteers
- 384 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Dystonia
Dystonia Coalition Projects
Dystonia is a disorder characterized by excessive involuntary contraction of muscles with repetitive and patterned movements. The primary focal dystonias are the most common type of dystonia and include Limb dystonias (like…
- Trial name
- NCT04156022
- Testing
- Dystonia Coalition is an observational study.
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Spasmodic Dysphonia, Singer's Dystonia
Brain Networks in Dystonia
To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia.
- Conditions
- Spasmodic Dysphonia, Singer's Dystonia, Writer's Cramp, Musician's Focal Hand Dystonia
- Trial name
- NCT03042962
- Testing
- MRI, Blood draw
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Presbylarynx, Aspiration
Assessment of Laryngopharyngeal Sensation: Cancer Survivor Cohort
A previous study completed in 2022 (NCT05158179) was conducted using cohorts of healthy controls, and adults with general laryngopharyngeal disorders.
- Conditions
- Presbylarynx, Aspiration, Spasmodic Dysphonia, Globus Pharyngeus
- Trial name
- NCT06078527
- Testing
- Cheung-Bearelly Aesthesiometer, Transnasal Laryngoscopy, Questionnaires
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Laryngeal Dystonia
Brain Network Changes After Vibro-tactile Stimulation in Laryngeal Dystonia
Laryngeal dystonia (LD) is a focal dystonia affecting laryngeal muscles, causing involuntary spasms that impair speech production.
- Trial name
- Neuro-VTS-LD (NCT07443891)
- Testing
- Vibrotactile Stimulation (VTS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Spasmodic Dysphonia, Dystonia
Effect of Vocal Exercise After Botulinum Toxin Injection for Spasmodic Dysphonia
Studies have suggested that voluntary muscle exercise in the hand and face after botulinum toxin injection may enhance the clinical effects of the toxin.
- Trial name
- NCT00895063
- Testing
- Vocal Exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Voice Disorders
Dextromethorphan to Treat Patients With Voice Spasms
This study will examine how dextromethorphan, a drug that alters reflexes of the larynx (voice box), might change voice symptoms in people with voice disorders due to uncontrolled laryngeal muscle spasms.
- Trial name
- NCT00055549
- Testing
- Dextromethorphan, Lorazepam
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)