Clinical trials: Specificity
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Major Depressive Disorder
The Biological Specificity of Acupoints Between Major Depressive Disorder Patients and Healthy Controls
Evidence-based medicine suggests that acupuncture can improve major depressive disorder (MDD). However, the prevalent reliance on experiential acupoint selection lacks scientific underpinning.
- Trial name
- NCT06114342
- Where
- China
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Xiaomei Shao
Post-natal Cytogenetics
Method Comparison and Clinical Specificity Study: Evaluation of the Infinium HD Cytogenetic Abnormality Test
The study will determine the performance of the Infinium HD Test. The primary objective of the study is to assess the performance of the Infinium HD Test using banked DNA samples extracted from whole blood patient samples derived…
- Trial name
- NCT01426308
- Where
- 3 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Illumina, Inc.
PREMATURE RUPTURE OF MEMBRANES
AL-SENSE 1-Step - Determination of Product Specificity
Clinical diagnosis of amniotic fluid leak will be determined, according the hospital standard procedure, using pooling test and/or sterile speculum examination and /or pH test, and AmniSure, N-Dia, Inc.
- Trial name
- ROM (NCT01804348)
- Testing
- AL-SENSE 1-Step
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Common Sense
Dry Eye
RPS InflammaDry Detector™ to Determine MMP-9 Levels in Tears
The RPS InflammaDry Detector™ is intended to detect elevated MMP-9 in human tears to aid in the diagnosis of patients with signs or symptoms of dry eye disease, in conjunction with other methods of clinical evaluation.
- Trial name
- NCT01313351
- Testing
- RPS InflammaDry Detector™
- Where
- 8 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Rapid Pathogen Screening
To Evaluate the Sensitivity and Specificity of a Test Kit in Hong Kong
The Diagnostic Accuracy of Using Faecal-DNA Test (COLOSAFE) for Colorectal Cancer Screening
To evaluate the sensitivity and specificity of the test kit "COLOSAFE' in Hong Kong
- Trial name
- NCT04030637
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Syphilis, Treponema Pallidum
A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.
Due to the recent resurgence of infectious syphilis in Canada and the changing epidemiology of the disease to involve heterosexuals and females of child bearing age leading to a record number of congenital syphilis cases and…
- Trial name
- NCT06586905
- Testing
- Medical Device
- Where
- Canada
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- MedMira Laboratories Inc.
Medication Review
APHID- Primary Care Accuracy Study
We are studying patients' abilities to correctly identify the prescription medications they are taking. We are interested in understanding what tools will help patients correctly identify their medications.
- Trial name
- NCT02135731
- Testing
- Medication review software with pictures
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Blake Lesselroth
Intervertebral Disc Displacement, Intervertebral Disc Degeneration
Lumbar Disc Space Height in Young Disc Herniation and Degeneration Patients
As low back pain (LBP) imposes a heavy socioeconomic burden, early detection of pathologic intervertebral disc change in young adults holds high clinical relevance as a common structural cause of LBP.
- Conditions
- Intervertebral Disc Displacement, Intervertebral Disc Degeneration, Low Back Pain
- Trial name
- NCT02351206
- Testing
- x-ray, MRI
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Jaseng Hospital of Korean Medicine
Septic Shock, Fluid Reponsiveness
This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload
Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.
- Trial name
- lvotvti (NCT07797751)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cow's Milk Allergy
Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
Study to assess the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of DBV1605 for the diagnosis of non-Immunoglobulin E (IgE) mediated cow's milk allergy (CMA) in children with symptoms…
- Trial name
- APTITUDE (NCT04492683)
- Testing
- DBV1605
- Where
- 33 sites in United States, Canada and 2 more
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- DBV Technologies
Dyslexia, Dysphasia
Developmental Language Difficulties: Behavioural and Electrophysiological Studies
This study will help to better characterize oral and written language disorders and determine if these disorders are continuous or not.
- Trial name
- LANGAGE (NCT02872870)
- Testing
- auditory lexical decision task, electroencephalogram
- Where
- 3 sites in Belgium, France
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Healthy Volunteer
A Prospective Study to Evaluate the Specificity of the Cobas TaqScreen MPX Test for Use on the Cobas s 201 System for Screening Plasma Pools From Source Plasma Donors for the Presence of HBV DNA, HCV RNA, and HIV-1 RNA
This study will evaluate the specificity of the cobas TaqScreen MPX Test for the simultaneous detection of HBV DNA, HCV RNA and HIV-1 Group M in a minimum of 100,000 individual donor samples in 96-unit pools.
- Trial name
- NCT00520273
- Testing
- cobas s 201 TaqScreen MPX Test
- Where
- 3 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Gastric Cancer
Measuring the Negative Predictive Value and Specificity of Serum Biomarkers in Gastric Cancer
Atrophic gastritis where the cells of the stomach lining change is the single most important precursor condition for gastric cancer.
- Trial name
- NCT06305169
- Testing
- Gastropanel
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Sepsis
Validation of Progranulin as a Biomarker for Sepsis
Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.
- Trial name
- PROGRANULIN (NCT03280576)
- Where
- 2 sites in Germany
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Human African Trypanosomiasis, Sleeping Sickness
Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring
This study determines the feasibility, diagnostic performance and cost for monitoring of eliminated human African trypanosomiasis (HAT) foci using diagnostic algorithms of serological and molecular high throughput tests with and…
- Conditions
- Human African Trypanosomiasis, Sleeping Sickness, Trypanosoma Brucei Gambiense; Infection, West African Sleeping Sickness
- Trial name
- DiTECT-HAT-WP3 (NCT04099628)
- Testing
- Rapid diagnostic test (RDT); Serological and molecular tests on DBS
- Where
- 3 sites in Burkina Faso, Côte d’Ivoire and 1 more
- Volunteers
- 13,747 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Neuroendocrine Neoplasms
A Prospective, Open-label Study of [68Ga]Ga-DOTA-TATE in Patients With Neuroendocrine Neoplasms (NENs) and Healthy Volunteers in Japan
The purpose of this study was to evaluate the diagnostic performance of [68Ga]Ga-DOTA-TATE Positron Emission Tomography (PET)/Computerized Tomography (CT) imaging compared with conventional imaging (CIM) as standard of truth in…
- Trial name
- NCT06240741
- Testing
- [68Ga]Ga-DOTA-TATE, 68Ge/68Ga Generator
- Where
- 8 sites in Japan
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Dyspnea
Specificity of Dyspnoea Relief With Inhaled Furosemide
This study evaluates the effect of inhaled furosemide on different types of breathlessness relief in healthy volunteers. Each volunteer inhaled mists of either furosemide or a control substance on 3 occasions per day on 2…
- Trial name
- FurosAH (NCT02881866)
- Testing
- Furosemide, Saline
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
COVID-19
Diagnostic Value of Patient - Reported and Clinically Verified Olfactory Disorders (COVID-19)
Participants are healthcare workers and adult outpatients referred in a COVID-19 screening center. Patients-reported symptoms are collected, then participants underwent a simple olfactory test (CODA for Clinical Olfactory…
- Trial name
- COVID-OLFA (NCT04407494)
- Testing
- Reporting of anosmia, ageusia and other clinical symptoms
- Where
- France
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
Intradermal Acupuncture Based on Changes in Biological Specificity of Acupoints for Major Depressive Disorder
Acupoints are the stimulus points and reactive points for acupuncture to treat diseases. Therefore, this study is designed to detect the pain threshold and temperature of biological specificities of acupoints in healthy control…
- Trial name
- NCT05524519
- Testing
- Basic treatment, PSA, TSA
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University