Clinical trials: Speech, open to volunteers
Healthy Volunteer
NEURO-IS: Neurophysiology of Inner Speech Across Neurotypical Participants.
The purpose of this study is to investigate the brain activity associated with two common inner experiences: visual mental imagery (mentally seeing objects or actions) and inner speech (experiencing language without speaking out…
- Trial name
- NEURO-IS (NCT07885020)
- Testing
- Inner Experience Induction Tasks and hdEEG
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Liege
Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis)
Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS)
Eighteen million people worldwide are affected by speech disorders. Locked-in syndrome (LIS) represents the most extreme form of communication disability resulting from motor impairment.
- Trial name
- SpeechBCI (NCT07698496)
- Testing
- Chronic speech BCI
- Where
- 4 sites in France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Aphasia
Neural Bases of Vocal Sensorimotor Impairment in Aphasia
Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control.
- Trial name
- NCT04742894
- Testing
- Visual Feedback Training
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Stuttering
Development and Pilot Testing of Virtually Simulated Intervention for Patients Having Stuttering
This study aims to develop and pilot test a culturally appropriate virtual reality (VR)-based speech restructuring intervention for individuals with stuttering in Pakistan.
- Trial name
- NCT07833969
- Testing
- Virtually Simulated Intervention
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Riphah International University
Stroke, Aphasia
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment.
- Conditions
- Stroke, Aphasia, Reading Disorder
- Trial name
- NCT06213272
- Testing
- Phono-Motor Therapy, Aerobic Exercise Training (AET), Stretching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Kessler Foundation
Spine, Low Back Pain
Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain
The goal of this randomized cross-over mechanistic trial is to compare pre- and post-level cortisol and oxytocin changes in patients with chronic spine pain who receive either a hand's on (massage) or a hand's off (talk-based)…
- Conditions
- Spine, Low Back Pain, Neck Pain
- Trial name
- COTHA (NCT06987786)
- Testing
- Massage, Talk-based therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Hearing, Healthy
Understanding Speech in Background Noise
The goal of this clinical trial is to establish how speech understanding is affected by background noise in people with normal hearing.
- Conditions
- Hearing, Healthy, Speech Perception
- Trial name
- NCT07822802
- Testing
- Speech filtering, Speech with background noise
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Conductive Hearing Loss
Wideband Tympanometry as a Non-behavioral Test of the Speech-weighted Middle Ear Transfer Function.
There is a need for a non-behavioral clinical test that provides an assessment of how speech is conducted through the middle ear for the optimization of middle ear implants.
- Trial name
- NCT07557771
- Testing
- Wideband Tympanometry
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ankyloglossia, Impairment of Speech
Effectivity of P1821, a Novel Tongue Strengthening and Endurance Enhancing Speech Flow Exercise
The P1821 initiative constitutes an innovative intervention specifically engineered to enhance tongue muscular strength and endurance.
- Conditions
- Ankyloglossia, Impairment of Speech, Slurred Speech
- Trial name
- NCT07719582
- Testing
- P1821
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dream Video LLC
Expressive Aphasia, Aphasia Following Cerebral Infarction
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Aphasia (BG-Aphasia-01)
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with aphasia to generate text on a computer screen and audible…
- Conditions
- Expressive Aphasia, Aphasia Following Cerebral Infarction, Aphasia Following Nontraumatic Intracerebral Hemorrhage, Aphasia Non Fluent
- Trial name
- BG2-Aphasia-01 (NCT07791459)
- Testing
- BrainGate Neural Interface System
- Volunteers
- 5 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Total Thyroidectomy
Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy
In this clinical trial, the investigators are seeking to learn if a course of voice therapy, including neck massage, stretches and pain science education in addition to voice exercise and scar massage will effectively treatment…
- Trial name
- Man Total Thy (NCT06383091)
- Testing
- Anterior Neck Manual Therapy, Pain Neuroscience Education, Neck Stretches
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Speech
Elicitation of Steady-state Audiovisual Responses in 6- and 10-month-old Infants
The goal of this study is to investigate the preferential responses of speech neural systems in infants. The main question it aims to answer is to determine whether the oscillatory synchronization capacity is associated with…
- Trial name
- AV-SSR-I (NCT06282289)
- Testing
- Magnetoencephalography (MEG), Cognition development questionnaire
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Myasthenia Gravis Generalised
Detecting Fatigue From Voice in Generalised Myasthenia Gravis
The goal of this observational study is to learn if computer analysis of voice recordings can detect a type of exhaustion called "central fatigue" in adults with generalised myasthenia gravis.
- Trial name
- NCT07033559
- Volunteers
- 240 people
- Sponsor
- Thymia Limited
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Remote Digital Assessments for Cognitive Disorders
Memory and thinking problems in older adults, including mild cognitive impairment (MCI) and Alzheimer's disease (AD), can be difficult to assess promptly because evaluation often depends on in-person specialist visits.
- Trial name
- MonitorCog-AI (NCT07883746)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs)
The Signature of Alzheimer's Disease in Subjective Cognitive Decline
This study focuses on improving early detection of Alzheimer's disease (AD) in patients with subjective cognitive decline (SCD), a preclinical stage of cognitive impairment, in the context of emerging disease-modifying therapies…
- Conditions
- Subjective Cognitive Decline (SCD), Subjective Cognitive Complaints (SCCs), Subjective Cognitive Impairment, Subjective Cognitive Concerns
- Trial name
- SIGN-AL (NCT07402161)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Policlinico S. Donato
Childhood Apraxia of Speech
Motor-based Intervention for Childhood Apraxia of Speech: DTTC-Connect
Childhood apraxia of speech (CAS) is a complex motor speech disorder that significantly limits a child's ability to communicate in daily activities, with difficulties often persisting into adolescence and adulthood.
- Trial name
- NCT07526246
- Testing
- Dynamic Temporal and Tactile Cueing - Connect (DTTC-Connect)
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- New York University
Mouthguard Use, Orofacial Injuries Prevention
Impact of 3D-Printed and Custom Mouthguards on Speech and Oral Functions in Children Practicing Contact Sports
This study aims to compare the effects of traditional and 3D-printed custom-made mouthguards on speech and oral functions in pediatric cases who practice contact sports by evaluating the comfort, fit, and performance of both…
- Conditions
- Mouthguard Use, Orofacial Injuries Prevention, 3D Printed Mouthguard, Traditional Custom-made Mouthguard
- Trial name
- Mouthguards (NCT06972823)
- Testing
- 3D printed custom-made mouthguards, Traditional custom-made mouthguards
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psychotic Disorder
Speech-based Assessment of Relapse Risk in People With Psychosis
This observational, multinational study assesses the feasibility of speech and self-report data collection across six languages for Artificial Intelligence (AI)-driven relapse risk estimation in psychosis.
- Trial name
- TRUSTING-WP4 (NCT07397975)
- Testing
- Weekly online speech assessments via a smartphone app collect speech and self-report data. Recordings are securely transferred and analyzed by an AI-based backend to calculate relapse risk scores.
- Where
- 7 sites in Czechia, Ireland and 4 more
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Philipp Homan