Clinical trials: Sperm Quality
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Male Infertility
Body Mass Index and Age Correlate With Antioxidant Supplementation Effects on Sperm Quality
Spermatozoa are vulnerable to lack of energy and oxidative stress as a result of elevated levels of reactive oxygen species. Therefore, it is essential that appropriate nutrients are available during maturation.
- Trial name
- NCT04177667
- Testing
- Proxeed
- Volunteers
- 104 people
- Sponsor
- University of Roma La Sapienza
Couple Sterility
Effect of Myoinositol Treatment of Spermatozoa on in Vitro Fertilization Outcome
In the present trial, the investigators aim to evaluate whether semen myo-inositol (MI) treatment is able to improve IVF outcomes.
- Trial name
- MI_ICSI (NCT02050672)
- Testing
- Myo-inositol, untreated
- Where
- Italy
- Volunteers
- 249 people
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Male Infertility
Effect of Antioxidant Probiotic Administration on Seminal Quality and Reproductive Outcomes.
The quality of semen plays a fundamental role in correct fertilization and development of normal embryos that result in a live birth. Unfortunately, semen quality has declined during the last decades, and reduced more and more.
- Trial name
- NCT04585984
- Testing
- Experimental - Probiotic
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fundación IVI
Infertility, Female
Impact of Gonadotrophin Releasing Hormone Analogues on Oocyte and Embryo Quality
The first In-Vitro Fertilization cycles were performed in natural unstimulated cycles. Today gonadotrophins are administered to induce multiple follicular development and controlled ovarian hyperstimulation.
- Trial name
- NCT03139474
- Testing
- Gonadotropin-Releasing Hormone Analogue, Gonadotropin releasing hormone antagonist
- Volunteers
- 120 people
- Sponsor
- Assiut University
Male Infertility, Oligoasthenospermia
Investigation of the Effects of Stem Cell Supportive Treatment on Semen Parameters and Assisted Reproductive Techniques (ICSI) in Infertile Male Patients With Oligoasthenospermia(Decrease Sperm Number and Quality)
This study evaluated whether Stemregen® dietary supplementation could improve sperm quality and assisted reproductive treatment outcomes in men with severe oligoasthenozoospermia who had previously experienced at least one failed…
- Trial name
- STEMRN (NCT07800052)
- Testing
- Stemregen
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
Healthy
Evaluation Of Sperm Production With Healthy Male Volunteers Receiving Lyrica Or Placebo
This study is being performed as a Phase IV FDA commitment study and is being powered adequately to assess changes in sperm concentration, FSH and testosterone in healthy male subjects treated with pregabalin as compared to…
- Trial name
- NCT00631696
- Testing
- Pregabalin
- Where
- 13 sites in United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Male Infertility, Oxidative Stress
Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress
The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality.
- Conditions
- Male Infertility, Oxidative Stress, Subfertility, Oligozoospermia
- Trial name
- G-OXSEM (NCT07375238)
- Testing
- Standardized Mediterranean Diet, Gazpacho
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Ginefiv
Polycystic Ovary Syndrome
Myo-Inositol for Ovarian Stimulation and ICSI Outcomes in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect ovarian function, insulin sensitivity, and fertility.
- Trial name
- NCT07779850
- Testing
- Myo-Inositol, Folic Acid
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kafrelsheikh University
Male Infertility With Severe Oligo-terato-asteno-spermia
Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate. Minor data is available regarding the influence on male sperm.
- Trial name
- Pomegranate (NCT01918163)
- Testing
- Pomegranate pills
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Gout
The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients：A Prospective Cohort Study
Gout is a kind of crystal-associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolic disorder and/or decreased uric acid excretion.
- Trial name
- INITIAL (NCT04213534)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Total Motile Sperm Count
The Effect of Lycopene on Sperm Quality in Men Attending Fertility Clinic
The goal of this clinical trial is to test whether lycopene (an antioxidant found in cooked tomatoes) will improve the number of swimming sperm in the ejaculates of men with low total motile sperm count.
- Trial name
- NCT05671562
- Testing
- Lycopene
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Unrecognized Condition
Male Supplements for Sperm Quality and Aging
This study investigates the effects of a new supplement on sperm quality in men with poor sperm quality. Fifty patients will receive the supplement for three months, followed by semen analysis and assessment of sperm aging and…
- Trial name
- NCT06339996
- Testing
- Male supplement
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Sperm Parameters of Spinal Cord Injured Men
Fertility of Spinal Cord Injured Men
Spinal cord injured (SCI) men, para or tetraplegic, most often have an infertility, caused among others by a deficiency of sperm quality particularly motility and vitality.
- Trial name
- FertiSCI (NCT02144558)
- Testing
- penile vibratory stimulation (PVS) or masturbation
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aging, Epigenetic Aging
Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging
This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age.
- Conditions
- Aging, Epigenetic Aging, Infertility, Assisted Reproduction Technologies
- Trial name
- NCT07814235
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IVI Murcia
Sperm Cryodamage
Effect of PRP in Donor Semen During Cryoprervation
Sperm cryopreservation allows the preservation of sperm biological function for long periods of time for later use in assisted reproductive techniques (ART).
- Trial name
- PRP (NCT07504575)
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Semen Quality
Sperm Quality in Consecutive Sperm Samples After 4-7 Days and 2 Hours of Sexual Abstinence
The main purpose of the study is to assess to which degree a series of sperm parameters known to be associated with fertilization and implantation potential in artificial reproductive technology (ART) differ in consecutive sperm…
- Trial name
- NCT02667080
- Testing
- 2-7 days of Sexual abstinence, 2 hours of sexual abstinence
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Fertility Disorders
Effect of Oocyte Denudation Time and Intracytoplasmic Sperm Injection Time on Embryo Quality
An observational analytic retrospective study was conduct using cross-sectional study. The subject were oocytes from in-vitro fertilization procedures using the ICSI method at the assisted reproductive technology clinic in a…
- Trial name
- NCT05448859
- Testing
- intracytoplasmic sperm injection
- Volunteers
- 200 people
- Sponsor
- Universitas Padjadjaran
Infertility
Effect of Omega 3 Fats on Sperm Quality and Sexual Function
This study compares the effects of omega 3 fats plus folic acid with placebo plus folic acid on sperm quality and sexual function in infertile men.
- Trial name
- NCT00406874
- Testing
- omega 3 fats, folic acid
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Reproductive Partners Medical Group
Infertility, Male
Sperm Selection Using Microfluidic Technology
This clinical study has been organised to investigate whether microfluidic technology may be considered as a new procedure for routine sperm preparation during assisted reproduction.
- Trial name
- MSS (NCT04997070)
- Where
- Belgium
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel