Clinical trials: Spermatogenesis
Spermatogenesis and Semen Disorders, Infertility, Male
Power Prenatal Supplements for Sperm Quality
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis [WHO 2020 - https://www.who.int/publications/i/item/9789240030787].
- Trial name
- NCT05410782
- Testing
- Power Prenatal for Sperm
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Hypogonadism, Male
Natesto Spermatogenesis Reboot
This is a prospective, non-blinded study of hypogonadal men with a history of testosterone therapy who became azoospermic or severely oligospermic and wish to avoid symptoms of hypogonadism during their recovery of…
- Trial name
- NCT05381831
- Testing
- NatestoTM
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Florida
Klinefelter Syndrome
Fertility Preservation in Cases of Klinefelter Syndrome.
Klinefelter Syndrome (KS) is the most common sex chromosomal abnormalities (1/600 newborn males), and is characterized by a hypergonadism hypogonadism.
- Trial name
- FERTIPRESERVE (NCT01918280)
- Testing
- Seminal analyses and testicular biopsy
- Where
- 4 sites in France
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Osteosarcoma
Biospecimen Analysis in Determining Effects of Chemotherapy on Fertility in Osteosarcoma Survivors
This research trial studies saliva, semen, and blood samples to determine effects of chemotherapy on fertility in osteosarcoma survivors.
- Trial name
- NCT03206450
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- 99 sites in United States, Canada and 1 more
- Volunteers
- 224 people
- Sponsor
- Children's Oncology Group
Erectile Dysfunction
Effect of TPN171H on Spermatogenesis
This study is a phaseⅠstudy to determine the acute effects of TPN171H on semen function in healthy male subjects.
- Trial name
- NCT05585931
- Testing
- TPN171H 10mg
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Human Volunteer
A Study to Examine the Effects of Minocycline Extended-Release Tablets on Sperm Production in Human Males.
Researchers want to find out how Minocycline Extended-Release Tablets affect sperm-production in healthy males. The study will include Minocycline Extended-Release Tablets, a new once-daily formulation of minocycline, compared…
- Trial name
- NCT00765336
- Testing
- minocycline extended release
- Where
- 10 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medicis Pharmaceutical Corporation
Contraception
NES Gel-1, To Evaluate Nestorone Gel in Combination With Testosterone Gel
The purpose of this study is to determine the usefulness of two transdermal gels to be used in the future development for a male contraceptive.
- Trial name
- NES-1 (NCT00229593)
- Testing
- Nestorone gel, Testosterone Gel
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Washington
Spermatogenesis and Semen Disorders, Infertility, Male
Evaluation of FPT-20 for the Treatment of Spermatogenesis and Semen Disorders
This clinical study aims to evaluate the efficacy and safety of a novel, natural-derived formulation (FPT-20) in supporting spermatogenesis.
- Trial name
- NCT05399212
- Testing
- FPT-20
- Where
- Vietnam
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Trieu, Nguyen Thi, M.D.
Contraception
Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (HOP 5) Testicular Aspiration Addendum
This study is being offered to all participants of the ACY-5 study as an optional addition to the male contraceptive study in which they participated. Participation is voluntary.
- Trial name
- IHOP-5 (NCT00156650)
- Testing
- Acyline, Testosterone Gel, Depo-Medroxyprogesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infertility, Non-obstructive Azoospermia
PET-MRI for Functional Imaging of the Testis: A Feasibility Study
The primary objective of this study is to explore feasibility of testis functionality assessment and testis imaging obtained from Positron Emissions Tomography (PET) /Magnetic Resonance Imagine (MRI).
- Conditions
- Infertility, Non-obstructive Azoospermia, Vasectomy
- Trial name
- NCT02669108
- Testing
- PET/ MRI of the Testis
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hypogonadotropic Hypogonadism, Type 2 Diabetes
Hypogonadism in Young Men With Type 2 Diabetes
Low testosterone production, known clinically as hypogonadism, appears to be common complication of type 2 diabetes, affecting one in three diabetic men.
- Trial name
- NCT01155518
- Testing
- testosterone, clomiphene
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- State University of New York at Buffalo
Spermatogenesis and Semen Disorders, Infertility, Male
Prospective Study on Power Prenatal Vitamins for Males on YO Score At-home Sperm Test Results
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis.
- Trial name
- NCT05951075
- Testing
- Power Prenatal for Sperm
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Hypogonadism, Hypogonadotropic Hypogonadism
A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)
This study will assess if corifollitropin alfa (MK-8962), when administered in combination with human chorionic gonadotropin (hCG), will increase testicular volume in men with HH who remain azoospermic after treatment with hCG…
- Trial name
- NCT01709331
- Testing
- Corifollitropin alfa, hCG
- Volunteers
- 18 people
- Sponsor
- Organon and Co
Healthy, Men
Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men
This is a Phase IIa multicenter, double-blind, placebo-controlled study in healthy men to evaluate the spermatogenesis suppression after oral administration of Dimethandrolone Undecanoate (DMAU) alone or with Levonorgestrel (LNG)…
- Conditions
- Healthy, Men, Male Contraception
- Trial name
- NCT03455075
- Testing
- Dimethandrolone-Undecanoate, Levonorgestrel 0.03 MG
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Premier Research
Erectile Dysfunction
Study Evaluating the Effects of Avanafil on Semen Parameters
The purpose of this study is to determine whether avanafil will affect different aspects of sperm production.
- Trial name
- NCT01768676
- Testing
- avanafil
- Where
- 15 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Male Infertility
Spermotrend in the Treatment of Male Infertility
The purpose of this study is to determine whether the administration of the dietary supplement Spermotrend improves spermatogenesis parameters in subjects with male infertility unrelated to major testicular conditions.
- Trial name
- NCT00975117
- Testing
- Spermotrend
- Where
- Cuba
- Volunteers
- 86 people
- Sponsor
- Catalysis SL
Male Infertility
Tobacco and Sperm Genome: Effects of Smoking Cessation
Tobacco is a male infertility risk factor. Many studies comparing smokers to non-smokers have shown effects on spermatogenesis and the quality of the male gamete.
- Trial name
- TABAGERM (NCT03552081)
- Testing
- Fragmented DNA evaluation in blood and semen samples
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Gonadotropin Deficiency
ITT-5 Mechanisms of Spermatogenesis in Man
The purpose of this investigational drug study is to determine how much male hormone, testosterone, is needed to maintain sperm production in the testis.
- Trial name
- ITT-5 (NCT02147964)
- Testing
- Testosterone 1% Gel, Acyline, Dutasteride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Cytomegalovirus Infections
A Study on Spermatogenesis in Male Renal Transplant Recipients Receiving Valganciclovir (Valcyte®) Versus Untreated Matched Controls
This observational study will compare spermatogenesis in male adult renal transplant recipients receiving valganciclovir versus untreated matched controls.
- Trial name
- NCT01663740
- Testing
- Valganciclovir
- Where
- 19 sites in United States, Mexico
- Volunteers
- 59 people
- Sponsor
- Hoffmann-La Roche
Male Contraception
Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males
This is a Phase 1b/2a open-label, dose escalation 3 part-study, 28-day, 90-day or 180 day repeat dose study of YCT-529 in healthy males who have decided to have a vasectomy and are waiting for the procedure and for men who have…
- Trial name
- NCT06542237
- Testing
- YCT-529
- Where
- New Zealand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- YourChoice Therapeutics, Inc.