Clinical trials: Spermatozoa
Infertility, Male Factor
FemaSeed LOCAL Artificial Insemination Trial
Brief Summary: The objectives of the trial are to evaluate the safety and effectiveness of the FemaSeed Localized Directional Insemination for artificial insemination, now known as the FemaSeed Intratubal Insemination since FDA…
- Trial name
- LOCAL (NCT04968847)
- Testing
- FemaSeed Localized Directional Insemination
- Where
- 18 sites in United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Femasys Inc.
Avanfil ADME, Semen Exposure
A Pharmacokinetic Study of Avanfil in Healthy Young Male Subjects
The purposes of this study are to: Determine the effect of the study drug on sperm and semen of healthy young male subjects. Determine the effect of age on the amount of study drug in the blood of healthy subjects Learn about the…
- Conditions
- Avanfil ADME, Semen Exposure, Sperm Function
- Trial name
- NCT00914511
- Testing
- avanafil 200mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
to Aid in Sperm Selection for ICSI
User Site Testing Study to Evaluate Usability of the Q300™ Device Under "Real-life Conditions" in a Reproductive Laboratory Environment Use
User Site Testing Study to evaluate usability of the Q300™ device under "real-life conditions" in a reproductive laboratory environment use.
- Trial name
- NCT06232720
- Testing
- Q300 QART Medical
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- QART Medical
Erectile Dysfunction
A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg
This is a multicenter, randomized, double-blind, placebo-controlled, fixed dose, parallel design study to evaluate effects on semen characteristics after 40 weeks of daily dosing with 20 mg tadalafil.
- Trial name
- NCT00382135
- Testing
- tadalafil
- Where
- United States
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Male Contraception
Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males
This is a Phase 1b/2a open-label, dose escalation 3 part-study, 28-day, 90-day or 180 day repeat dose study of YCT-529 in healthy males who have decided to have a vasectomy and are waiting for the procedure and for men who have…
- Trial name
- NCT06542237
- Testing
- YCT-529
- Where
- New Zealand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- YourChoice Therapeutics, Inc.
Sperm Parameters in Fertile and Infertile Men
Evaluation of New Semen Collection & Transportation Kit
Examine the effect of overnight transport conditions on sperm parameters on semen samples collected and mailed to Cleveland Clinic Andrology center.
- Trial name
- NCT04536545
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Turtle Health, Inc.
Contraception
An Exploratory Study of ZB-06 as a Vaginal Contraceptive Film
This is an early Phase 1 study to establish proof-of-concept by determining whether an intravaginal film containing a human contraceptive antibody (ZB-06) shows promise to provide contraceptive efficacy using the post-coital…
- Trial name
- NCT04731818
- Testing
- ZB-06
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KBio Inc
Male Infertility, Azoospermia
Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)
This study looks at an investigational automated, artificial intelligence (AI)-based sperm selection technology called the BAIBYS™ System.
- Trial name
- Benchmark (NCT06990906)
- Testing
- BAIBYS Sperm selection, Intra cytoplasmatic sperm injection, Conventional manual sperm selection
- Where
- 3 sites in United States, Israel and 1 more
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- BAIBYS Fertility
Healthy Subjects
Phase 1 Study of Intravaginal KB15A
The goal of this clinical trial is to determine the safety and mucosal pharmacokinetics of KB15A, a vaginal film containing an anti-sperm monoclonal antibody, in healthy adult women.
- Trial name
- NCT07222020
- Testing
- KB15A Vaginal Film
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ZabBio Inc.
Spermatogenesis and Semen Disorders, Infertility, Male
Power Prenatal Supplements for Sperm Quality
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis [WHO 2020 - https://www.who.int/publications/i/item/9789240030787].
- Trial name
- NCT05410782
- Testing
- Power Prenatal for Sperm
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Male Infertility, Low Sperm Quality
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility
This study will evaluate the effects of the WeNatal For Him supplement on markers of male fertility over a 3-month period. The trial is a single-arm, unblinded study enrolling 40 male participants who will take 3 capsules of the…
- Conditions
- Male Infertility, Low Sperm Quality, Low Testosterone, Low Energy
- Trial name
- NCT07740161
- Testing
- WeNatal For Him Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Fertility, Male, Sub-Fertility, Male
Study of the Consumer Use of a New Home Test to Measure Sperm Concentration
The objective of the study is to evaluate the agreement in measurement of sperm concentration in human semen between lay users with TRAK and a recognized reference method.
- Trial name
- NCT02475395
- Testing
- TRAK device
- Where
- 3 sites in United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Sandstone Diagnostics
Infertility
Automated Sperm Sample Preparation Protocol
This clinical trial would be directed at determining the effectiveness of an innovative sperm sample preparation protocol for intrauterine insemination (IUI).
- Trial name
- NCT03999762
- Testing
- sample prep
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nanonc Inc.
Male Contraception
First in Human Study Evaluating Single Ascending Oral Doses of YCT-529 in Healthy Males
A single ascending oral dose(s) study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of YCT-529 in healthy male subjects.
- Trial name
- NCT06094283
- Testing
- YCT-529
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- YourChoice Therapeutics, Inc.
Male Infertility
A Novel Sperm Selection Method Provides Advantages Over Conventional Approaches
The goal of this clinical trial is to know if a novel sperm selection device (CA0) has a similar performance than the standard selection method in teratozoospermic and azoospermic men.
- Trial name
- NCT06545318
- Testing
- Density Gradient Centrifugation, CA0 chamber
- Where
- Mexico
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Center of Innovation Technology & Reproductive Medicine
Erectile Dysfunction
Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function
Assess the effect of daily treatment of vardenafil 20mg or sildenafil 100mg and placebo on sperm function
- Trial name
- NCT00655590
- Testing
- Levitra (Vardenafil, BAY38-9456), Sildenafil
- Where
- 18 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bayer
Male Infertility
A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0
The purpose of this study is to determine if elevations in oxidative stress, as measured by oxidation-reduction potential (ORP), can distinguish between semen samples from men with abnormal semen parameters from those with normal…
- Trial name
- NCT02839447
- Testing
- Diagnostic
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aytu BioPharma, Inc.
Male Contraception, Semen Volume
Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive
NLS-133-CLIN001 is a Phase 2a study designed to assess the safety, tolerability, and effects of NLS-133 (combination of two FDA-approved agents) compared to an active control (FDA-approved pharmacologic agent) or placebo on semen…
- Conditions
- Male Contraception, Semen Volume, Sperm Motility
- Trial name
- NCT07393334
- Testing
- NLS-133, Active Comparator #1
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Next Life Sciences
Male Infertility
Efficacy Study of a Food Supplement With Myo-inositol, N-Acetyl-Cystein, Zinc and Vitamins on Sperm DNA Fragmentation
In industrialised countries, it is estimated that about 15% of couples who wish to have a child are currently facing infertility problems, of which, in half of the cases, an anomaly in sperm quality or at least a factor of male…
- Trial name
- NCT04959864
- Testing
- Isitol®
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GYNOV
Sperm Classification
Sperm Video Recording Protocol
The purpose of this study is to obtain anonymous video clips of male semen at high magnification, to manually select out of the video spermatozoon images, and to manually classify their morphology by qualified embryologists based…
- Trial name
- NCT06150846
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- BAIBYS Fertility