Clinical trials: Spinal
Brain Injuries, Stroke
The Impact of a Societal Lockdown on Those With Spinal Cord and Brain Injuries
Document and evaluate the impact of societal restrictions due to the pandemic on SCI- and ABI-related disability and functional impairments, and the resultant effects on psychological wellbeing, physical wellbeing and quality of…
- Conditions
- Brain Injuries, Stroke, Spinal Cord Injuries
- Trial name
- NCT04426071
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Poliomyelitis
Safety and Immunogenicity of a New Inactivated Poliovirus Vaccine in Infants
A new inactivated polio vaccine based on attenuated poliovirus strains was developed to transfer the technology to manufacturers in low- and middle-income countries.
- Trial name
- NCT01709071
- Testing
- IPV, Low dose Sabin-IPV, Low dose adjuvanted Sabin-IPV
- Where
- 7 sites in Poland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Pauline Verdijk
Castration-resistant Prostate Cancer, Metastatic Cancer
pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer
This trial will evaluate the use of one versus two DNA vaccines, delivered concurrently with PD-1 blockade using pembrolizumab followed by treatment with pembrolizumab alone, and delivered over a prolonged period of time (for a…
- Conditions
- Castration-resistant Prostate Cancer, Metastatic Cancer, Prostate Cancer
- Trial name
- NCT04090528
- Testing
- pTVG-HP, pTVG-AR, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Madison
Minimally Invasive Surgery, Spinal Metastases
Robot-assisted Invasion-controlled Surgery Versus Traditional-open Surgery Against Metastatic Spinal Tumor
With significant advances in diagnostic imaging and systemic therapies for oncologic disease, spinal metastasis with neurological dysfunction and mechanical instability has become an indication for surgery.
- Trial name
- NCT05173467
- Testing
- Robot-assisted Invasion-controlled Surgery, Traditional-open Surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wei Xu
Degenerative Disc Disease, Degenerative Spondylolisthesis
The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy
The five-repetition sit-to-stand test (5R-STS) has been used in many medical disciplines, but has never been correlated with or validated in regard to degenerative spinal diseases.
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Herniated Disc, Stenosis, Spinal
- Trial name
- 5R-STS (NCT03303300)
- Where
- Netherlands
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Marc Schröder
Spinal Cord Injury
A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the Spanish Healthcare System
This clinical trial aims to collect evidence on the clinical benefits and the socioeconomic impact of integrating a novel wearable powered lower-limb exoskeleton for gait rehabilitation in acute/subacute spinal cord injured…
- Trial name
- NCT07036107
- Testing
- ABLE Exoskeleton, Conventional therapy
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- ABLE Human Motion S.L.
Hypotension, Spinal Anesthesia
Norepinephrine or Phenylephrine in Bolus for Hypotension in Cesarean Delivery
This study evaluate the ability of phenylephrine and of noradrenaline to maintain normal systemic arterial blood pressure and heart rate in healthy pregnant women submitted to cesarean section with spinal anesthesia.
- Trial name
- NCT03702400
- Testing
- Phenylephrine 100 mcg, Norepinephrine 5 mcg
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Rheumatoid Arthritis, Psoriatic Arthritis
Research Study on the Immunosuppressive Effects of a Cell Therapy Product on PBMC Isolated From Blood of Patients With Inflammatory Rheumatic Diseases
Rheumatic diseases regroup a variety of disorders affecting the locomotor system including joints, muscles, connective tissues and soft tissues around the joints and bones.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthritis
- Trial name
- NCT03454932
- Testing
- Blood sampling
- Volunteers
- 30 people
- Sponsor
- Bone Therapeutics S.A
Psoriasis, Psoriatic Arthritis
Danish Population-based Assessment of Psoriasis and Psoriatic Arthritis (DANPAPP)
3-part study of patients with psoriasis, including 1) a population based questionnaire 2) cross-sectional clinical study with focus on musculoskeletal ultrasound and patient reported outcomes 3) 12 months follow-up study of…
- Trial name
- DANPAPP (NCT04515732)
- Testing
- Apremilast Oral Tablet
- Where
- 2 sites in Denmark
- Volunteers
- 115 people
- Sponsor
- Professor Mikkel Østergaard
Fetal Congenital Abnormalities, Fetoscopy
Fetoscopic Robotic Open Spina Bifida Treatment
Fetal spina bifida is a common birth defect that results in hydrocephalus, motor-, bowel-, bladder- and sexual dysfunction in the child. The condition is progressive in utero.
- Conditions
- Fetal Congenital Abnormalities, Fetoscopy, Fetal Surgery, Robotic Surgical Procedure
- Trial name
- FROST (NCT06907732)
- Testing
- Fetoscopic robotic open spina bifida closure
- Volunteers
- 15 people
- Sponsor
- Mount Sinai Hospital, Canada
CerebroSpinal Fluid (CSF) Leak
The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)
Spinal CSF leaks are considered as rare disease. They cause a variety of symptoms, mainly culminating in a chronic headache syndrome. Crucially, yet often disregarded, the disease holds the potential for cure.
- Trial name
- SEAL (NCT06711731)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Freiburg
Axial Spondyloarthritis
British Axial Spondyloarthritis Inception Cohort
The British Axial Spondyloarthritis Cohort (BAxSIC) study has been established under the auspices of the British Society for Spondyloarthritis (BRITSpA) in collaboration with the National Axial Spondyloarthritis Society (NASS) to…
- Trial name
- BAxSIC (NCT05676775)
- Testing
- No intervenetion
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Spinal Cord Injuries
FES-assisted Gait Intervention in People with Spinal Cord Injury - Pilot Study
A spinal cord injury (SCI) disrupts the communication within the nervous system, leading to limitations in sensorimotor activities such as walking.
- Trial name
- NCT05908175
- Testing
- FES-assisted gait training
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Stichting Reade
Ankylosing Spondylitis
Effectiveness and Safety of Early Treatment With Infliximab for Hip Arthritis Associated With Ankylosing Spondylitis (AS) (P06451)
This trial is designed to measure improvement of hip involvement in patients with ankylosing spondylitis (AS) after receiving 4 doses of infliximab.
- Trial name
- HACER (NCT01148901)
- Testing
- Infliximab
- Sponsor
- Merck Sharp & Dohme LLC
Nociceptive Pain
Cervical Neuromodulation and Nociceptive Processing
Several studies have demonstrated that direct currents delivered through the skin at the level of the lumbar spinal cord can influence spinal cord function.
- Trial name
- MICROVOLT (NCT05127200)
- Testing
- Starstim (Neuroelectrics)
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Pain
Compare the Efficacy and Safety of Norspan to Tramadol/Acetaminophen With Prolonged Postoperative Pain (PASSION)
The purpose of this study is to compare the efficacy and safety of buprenorphine transdermal system to tramadol/acetaminophen.
- Trial name
- NCT01983111
- Testing
- buprenorphine, tramadol/acetaminophen
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Mundipharma Korea Ltd
Chronic Inflammatory Disease
Chronic Inflammatory Rheumatism: Management of Comorbidities in Ambulatory Medicine
Identification of factors limiting compliance with the recommendations established during the evaluation of the SCORIC population by the rheumatology department of the CHU Grenoble Alpes
- Trial name
- SCORIC-A (NCT05613712)
- Testing
- Patients, Referring physician
- Where
- France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Grenoble
Low Back Pain and Core Muscle, Disc Herniation
Neural Control and Mechanosensation in Spine Muscle
Low back pain (LBP) is a condition that affects a majority of the US population and is responsible for a significant proportion of health care costs and utilization.
- Trial name
- NCT07003802
- Testing
- Resistance exercise
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Low Back Pain
Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain
The primary objective of this study is to document and compare diagnostic test results and procedure safety in subjects undergoing both Functional Anaesthetic DiscographyTM (F.A.D.) and provocative discography (PD) and determine…
- Trial name
- SODA (NCT00443781)
- Testing
- functional anesthetic discography, provocative discography
- Where
- 10 sites in United States
- Volunteers
- 62 people
- Sponsor
- Medtronic Spine LLC
Chronic Spinal Pain
Protocol for a Randomized Controlled Trial Comparing the Effectiveness of Mechanical Diagnosis and Therapy Versus Generalized Exercise for Reducing Pain in Surgeons With Chronic Spinal Pain
Surgeons frequently experience chronic spinal pain due to prolonged static postures and repetitive movements during surgical procedures.
- Trial name
- NCT07293130
- Testing
- Mechanical Diagnosis and Therapy (MDT), Generalized Exercise
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Claus Kjærgaard
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