Clinical trials: Spinal
Amyotrophic Lateral Sclerosis
Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients
Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is a fatal progressive neurodegenerative disease affecting motor cortex, brainstem and spinal cord leading to motor neuron death.
- Trial name
- NCT03377309
- Testing
- Fycompa
- Where
- Lebanon
- Volunteers
- 6 people
- Sponsor
- American University of Beirut Medical Center
Spondylarthritis, Spondylarthropathies
Core Stabilization Training in Juvenile Spondyloarthropathy
Core stabilization exercises developed by McGill have been shown to be one of the physiotherapy techniques aimed at reducing pain, increasing aerobic capacity, enhancing muscle strength, and thereby improving bone health in…
- Conditions
- Spondylarthritis, Spondylarthropathies, Juvenile Idiopathic Arthritis
- Trial name
- NCT06546293
- Testing
- core stabilization exercises, daily physical activity program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Pregnancy, Cesarean Section
Effects of High Flow Humidified Oxygen on Umbilical Artery Acid-base Balance in Cesarean Section Under Spinal Anesthesia
Spinal anesthesia is the most commonly used anesthetic technique for cesarean section in developed countries, but vasodilation and a decrease in systemic vascular resistance caused by sympathetic blockade result in hypotension in…
- Conditions
- Pregnancy, Cesarean Section, Spinal Anesthesia
- Trial name
- NCT07515716
- Testing
- high-flow nasal oxygen, conventional nasal cannula oxygen
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Lumbar Disc Herniation
Clinical Research on the Efficacy of Bosinji on Herniated Intervertebral Disc of Lumbar Spine
This randomized controlled clinical trial is designed to evaluate the efficacy and safety of Bosinji on low back pain and radiating pain of lumbar herniated intervertebral disc (L-HIVD) by assessing pain, function, and quality of…
- Trial name
- NCT03386149
- Testing
- Bosinji, Loxonine tab., Acupuncture
- Where
- 4 sites in South Korea
- Volunteers
- 74 people
- Sponsor
- Kyunghee University Medical Center
Spondylolisthesis
Efficacy of Hybrid Systems in Comparison to the Rigid Spondylodesis in Lumbar-spine Fusion
This study is designed as a randomized, parallel-group, therapy-controlled trial in a clinical care setting at a university hospital.
- Trial name
- D-Rod (NCT01852526)
- Testing
- Experimental: hybrid system, Active Comparator: Plif
- Where
- 2 sites in Germany
- Volunteers
- 5 people
- Sponsor
- University of Cologne
Spinal Tumor, Spinal Injury
Study of Collagen-Based Thrombin Hemostat for the Control of Bleeding in Spinal Surgery
This clinical trial evaluates the effectiveness and safety of a collagen-based hemostatic agent containing thrombin in patients undergoing spinal surgery.
- Conditions
- Spinal Tumor, Spinal Injury, Hemostasis, Spinal Stenosis
- Trial name
- NCT07354178
- Testing
- CollaStat®, Floseal®
- Where
- 3 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- DALIM TISSEN Co., Ltd.
Hypotension, Bradycardia
Effects of Ondansetron on Hemodynamic Changes After Spinal Anesthesia in Geriatric Urologic Surgery
Spinal anesthesia is frequently used in urologic surgery in geriatric patients; however, it may cause significant hemodynamic changes such as hypotension and bradycardia.
- Conditions
- Hypotension, Bradycardia, Hypotension During Surgery, Spinal Anesthesia Induced Hemodynamic Change
- Trial name
- NCT07551219
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injury
Study Effects of Intermittent Hypoxia on Restoring Hand Function Following SCI
The goal of the study is to examine the effects of repeated breathing episodes of mild intermittent hypoxia (reduced oxygen) training on hand strength and grasping ability following cervical spinal injury, and to determine…
- Trial name
- NCT01272336
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Emory University
Chronic Pain
Use of Dermabond in Mitigation of Spinal Cord Stimulation (SCS) Trial Lead Migration
During the typical SCS trial the leads remain outside of the skin and can be prone to migration. The leads are typically secured in place with suture, tape, or a combination of both.
- Trial name
- NCT05914311
- Testing
- Suture, Suture and Dermabond
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Low-back Pain, Herniated Disc
LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant
The study is a post-market surveillance study of the Lumbar Implant for Stiffness Augmentation (LISA), a medical device, which is used to treat low-back pain that accompanies degenerative lesions of grades II, III, and IV…
- Conditions
- Chronic Low-back Pain, Herniated Disc, Degenerative Disc Disease, Lumbar Canal Stenosis
- Trial name
- LISA-PMCF (NCT04631133)
- Testing
- Lumbar Implant for Stiffness Augmentation (LISA)
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 136 people
- Sponsor
- BACKBONE
Inflammatory Myelopathies
CNS Growth Factors Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects With Inflammatory Myelopathies
This research is being done to see how different amounts of Functional Electrical Stimulation (FES) affect cycling on factors in blood and spinal cord in people with spinal cord inflammation.
- Trial name
- FIRST-STIM (NCT01440452)
- Testing
- FES Cycling, Cycling without FES, Lumbar puncture
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Rheumatoid Arthritis, Psoriatic Arthritis
COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic Diseases
The trial is a prospective, observational study aiming to identify risk factors for serious COVID-19 infection by evaluating clinical measures and biomarkers of inflammation in patients with inflammatory rheumatic disease…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- NCT04335747
- Testing
- COVID-19 infection
- Where
- Denmark
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Salome Kristensen
Symptomatic Neurogenic Orthostatic Hypotension (NOH), Parkinson's Disease
Fipamezole in Neurogenic Orthostatic Hypotension
The purpose of this study is to determine whether Fipamezole is effective in the treatment of orthostatic hypotension and related symptoms in multiple system atrophy and Parkinson's disease.
- Conditions
- Symptomatic Neurogenic Orthostatic Hypotension (NOH), Parkinson's Disease, Multiple System Atrophy
- Trial name
- Foehn (NCT00758849)
- Testing
- Fipamezole
- Where
- 4 sites in France, Portugal
- Volunteers
- 24 people
- Sponsor
- Juvantia Pharma Ltd
Spinal Cord Injury
Testosterone and Neural Function in Men With Spinal Cord Injury
Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS).
- Trial name
- NCT06130449
- Testing
- Natesto testosterone intranasal gel, Ayr Saline Nasal Gel
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Injections, Spinal, Cancer
Place of Intrathecal Analgesia to Improve the Quality of Life of Painful Cancer Patients
The intrathecal analgesia is a recommended technic to treat persistent pain in cancer patient but little used, whose the technical conditions require hospital multidisciplinary expertise and coordination associated to a link…
- Trial name
- QUALITHEC01 (NCT04388449)
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Institut Cancerologie de l'Ouest
Rheumatoid Arthritis, Psoriatic Arthritis
Yoga-mindfulness for Pain Management in Inflammatory Arthritis
This study evaluates the potential effects on pain, pain-related symptoms and quality of life of a yoga-mindfulness program, compared to patient education and physiotherapy, for patients with inflammatory arthritis and persistent…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Pain
- Trial name
- NCT04065958
- Testing
- Yoga-mindfulness, Patient education and physiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Low Back Pain
Wallis Stabilization System for Low Back Pain
The purpose of this study is to demonstrate that the Wallis System (interspinous process implant) is equivalent to total disc replacement (TDR) for the treatment of mild to moderate degenerative disc disease (DDD) of the lumbar…
- Trial name
- NCT00484458
- Testing
- Interspinous process and dynamic stabilization (Wallis System), Total Disc Replacement
- Where
- 11 sites in United States
- Volunteers
- 340 people
- Sponsor
- Zimmer Spine
Amyotrophic Lateral Sclerosis
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS
A tele-health treatment study for individuals with early stage ALS with the aim to improve communication, cough response, and respiratory strength.
- Trial name
- NCT05003167
- Testing
- Expiratory Muscle Strength Training (EMST-150)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Purdue University
Acute Spinal Cord Injury, Spinal Cord Injuries
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI).
- Conditions
- Acute Spinal Cord Injury, Spinal Cord Injuries, Neuromodulation, Traumatic Spinal Cord Injury
- Trial name
- NCT06000592
- Testing
- Digitimer
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jill M. Wecht, Ed.D.
Diabetes, Cervical Myelopathy
Diabetes and Glycosylation in Cervical Spondylosis
The purpose of this study is to determine the relevant significance of diabetes on cervical disc degeneration, and correlate diabetic control (HgbA1C) with disc glycosylation profile in patients undergoing anterior cervical…
- Conditions
- Diabetes, Cervical Myelopathy, Cervical Spondylosis
- Trial name
- NCT02758899
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
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