Clinical trials: Spinal
Amyotrophic Lateral Sclerosis (ALS)
Tamoxifen Therapy in Amyotrophic Lateral Sclerosis [ALS]
This is a single-center, phase 2 randomized clinical trial of tamoxifen on mean percent predicted isometric muscle strength in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00214110
- Testing
- Tamoxifen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Spinal Cord Injuries
Treatment for Chronic Spinal Cord Injury: Surgery With Rehabilitation vs Rehabilitation
The purpose of this study is to investigate the efficacy of surgical decompression/untethering, combined with weight bearing rehabilitation, on neurological recovery following chronic spinal cord injury.
- Trial name
- NCT02663310
- Testing
- Surgery, Rehabilitation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Kunming Tongren Hospital
Lumbar Fusion, Lumbar Spinal Fusion Surgery
Clinical and Biomechanics Research in Core Muscles After Lumbar Fusion Surgery
Lumbar fusion has been widely used for spinal disorders when conservative treatment has failed. However, a number of studies have reported that the rate of re-operation is high for lumbar fusion surgery.
- Trial name
- NCT01703338
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Ankylosing Spondylitis
Study Evaluating Etanercept in Patients With Ankylosing Spondylitis
This study will assess the efficacy of etanercept for the treatment of Ankylosing Spondylitis (AS).
- Trial name
- NCT00458185
- Testing
- etanercept
- Volunteers
- 40 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Spinal Muscular Atrophy (SMA)
Adult SMA Research and Clinical Hub
Adult SMA REACH is a data collection study aiming to gain a better understanding of the impact of standards of care and new treatments on the natural history of Spinal Muscular Atrophy (SMA).
- Trial name
- REACH (NCT06978985)
- Testing
- Risdiplam, Nusinersen Injectable Product
- Where
- 18 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Arthritis, Psoriatic
A Study to Test Different Doses of BI 730357 and Find Out Whether They Reduce Symptoms in People With Active Psoriatic Arthritis
This study is open to adults with active psoriatic arthritis who have tender and swollen joints. The purpose of this study is to find out whether a medicine called BI 730357 helps to reduce symptoms and to prevent damage to…
- Trial name
- NCT04680676
- Testing
- BI 730357
- Sponsor
- Boehringer Ingelheim
Spinal Cord Injury
Improve Dynamic Lateral Balance of Humans With SCI
This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI.
- Trial name
- NCT02991248
- Testing
- robotic training, spinal cord electrical stimulation, treadmill
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Shirley Ryan AbilityLab
Amyotrophic Lateral Sclerosis
Xavier Electromyographic Wheelchair Control for Limited Mobility Patients
The purpose of this study is to assess the functional mobility and self-reported satisfaction with the Xavier electromyography hands-free wheelchair control system in comparison with a standard joystick.
- Trial name
- NCT04800926
- Testing
- Xavier wheelchair controller
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Diphtheria, Tetanus
Antibody Persistence at Age 3.5 and 4.5 Years After Primary and Booster DTaP-IPV-Hep B-PRP~T or Infanrix Hexa Vaccination
This is a follow-up of the primary series vaccination schedule in Study A3L24 (NCT01177722) and booster vaccination in Study A3L27 (NCT01444781).
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01983540
- Testing
- DTaP-IPV-Hep B- PRP~T + Prevenar + Rotarix vaccine, DTaP- IPV-Hep B-PRP~T + Prevenar + Rotarix + Infanrix hexa vaccine, Infanrix hexa + Prevenar + Rotarix vaccine
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Scoliosis; Adolescence, Myofascial Pain Syndrome
Prevalence of Myofascial Pain Syndrome in Adolescent Idiopathic Scoliosis
this is an observational and cross-sectional prevalence study. 10-18 years aged participants with adolescent idiopathic scoliosis were recruited in the study. Myofascial pain syndrome will be questioned to the participants.
- Conditions
- Scoliosis; Adolescence, Myofascial Pain Syndrome, Trigger Point Pain, Myofascial, Physical Medicine and Rehabilitation
- Trial name
- NCT05185050
- Testing
- physical examination and measurement of spinal alignment
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pain
Assessing the Efficacy of Virtual Reality Analgesia (VRA) in Adult Patients for Pain Control During Spinal Injections (SI)
A three-group parallel randomized controlled trial to evaluate the efficacy of virtual reality analgesia (VRA) to decrease patient procedural pain and anxiety in the Adult patients undergoing Spinal Injections (SI).
- Trial name
- VR adult (NCT03787147)
- Testing
- Google Cardboard, Oculus, Lidocaine Hydrochloride
- Volunteers
- healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Cervical Incompetence
Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC)
The investigator aimed to compare the effect of anesthesia on overall postoperative outcomes including post-operative pain score and the fetal well-being (heart rate) in patients undergoing transabdominal cervico isthmic…
- Trial name
- NCT03636048
- Testing
- Bupivacaine Hcl 0.5% Inj, Propofol 10 milligram/ML
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Spinal Cord Injury, Neurogenic Detrusor Overactivity
Is the Nerve Growth Factor (NGF) a Useful Biomarker in Neurogenic Bladder Dysfunction After Spinal Cord Injury?
Spinal cord injury (SCI) almost always affects bladder function as well. As a result of this bladder dysfunction, individuals with SCI have to undergo regular invasive examination of their bladder function (urodynamic…
- Conditions
- Spinal Cord Injury, Neurogenic Detrusor Overactivity, Neurogenic Lower Urinary Tract Dysfunction
- Trial name
- NCT02138149
- Where
- Switzerland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Ankylosing Spondylitis
Investigating the Use of Salaso to Improve Physiotherapy Management of Ankylosing Spondylitis (AS).
This is a pilot study to investigate the use of Salaso, a web based exercise app, to increase access to physiotherapy and improve physical activity in patients attending St James's Hospital Rheumatology for Ankylosing Spondylitis…
- Trial name
- NCT03457285
- Testing
- Physiotherapy
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- St. James's Hospital, Ireland
Rheumatoid Arthritis, Psoriatic Arthritis
Integration of Remote Monitoring in the Management of Chronic Immunosuppressive Therapy
Systemic autoimmune and chronic inflammatory diseases are a group of chronic illnesses whose treatment is usually very prolonged, often lifelong, and is essential to keep the disease under control, thus reducing the risk of…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis
- Trial name
- TEMPLATE (NCT06544343)
- Testing
- Remote Monitoring, On site monitoring
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- University Of Perugia
Amyotrophic Lateral Sclerosis
A Longitudinal Analysis of Biomarkers in Patients With ALS
Longitudinally collect biomarkers from patients with amyotrophic lateral sclerosis (ALS) and control participants in order to further elucidate both potential causes and treatments for ALS.
- Trial name
- LAB-PALS (NCT05309408)
- Testing
- Venipuncture, Lumbar Puncture
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Holy Cross Hospital, Florida
Lumbar Disc Herniation, Anular Tear of Lumbar Disc
Incidence of Large Annular Defects in Primary Lumbar Discectomy Patients
Lumbar discectomy study, collection and evaluation of incidence of large annular defects.
- Conditions
- Lumbar Disc Herniation, Anular Tear of Lumbar Disc, Nucleus Pulp Hernia;Lumbosac
- Trial name
- USLSI (NCT03252691)
- Where
- United States
- Sponsor
- Intrinsic Therapeutics
Amyotrophic Lateral Sclerosis (ALS)
Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS)
ALS is a disorder that weakens motor strength and lung function. Rapid loss of motor neurons in the brain and spinal cord of ALS patients causes the symptoms of increasing weakness and loss of muscle function.
- Trial name
- NCT01232738
- Testing
- rasagiline
- Where
- 10 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- Yunxia Wang, MD
Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis
Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion
The purpose of this study is to evaluate the safety and preliminary efficacy of NeoFuse in subjects with a diagnosis of degenerative disc disease (DDD) at 2 or more adjacent cervical vertebral levels between C3-C4 to C7-T1.
- Conditions
- Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
- Trial name
- NCT01106417
- Testing
- NeoFuse, MasterGraft Granules
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Mesoblast, Ltd.
Spinal Stenosis of Lumbar Region, Spine Degeneration
Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis
Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration.
- Trial name
- APIDeLeG (NCT07026552)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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