Clinical trials: Spinal
Psoriasis, Colitis, Ulcerative
A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
The purpose of this post-marketing study is to assess the amount of guselkumab in breast milk of lactating women receiving guselkumab as part of their standard clinical care provided by their treating physician, for any of the…
- Conditions
- Psoriasis, Colitis, Ulcerative, Crohn Disease, Arthritis, Psoriatic
- Trial name
- NCT07654751
- Testing
- Breast Milk Sample Collection, Guselkumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Janssen Research & Development, LLC
Chronic Pain, Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Pain in Chronic Pain Patients Undergoing Spinal Surgery
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, and lidocaine infusions can help reduce postoperative pain in opiate-dependent chronic…
- Trial name
- NCT02752477
- Testing
- Opioid-free general anesthetic, Traditional general anesthetic
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ben Lim
Non Traumatic Spinal Cord Injury, Sub-Acute Rehabilitation
Functional Electrical Stimulation vs Transcutaneous Stimulation in Patients With Subacute Spinal Cord Injury
Cervical spinal cord injuries (SCI) are the most common form of spinal cord injuries within the veteran population. Losing arm function is a major concern with these injuries.
- Conditions
- Non Traumatic Spinal Cord Injury, Sub-Acute Rehabilitation, Spinal Cord Injury Cervical, Electric Stimulation Therapy
- Trial name
- NCT07911657
- Testing
- RTI Xcite, ExaStim
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Center for Veterans Research and Education
Spinal Cord Injury at T1-T12 Level, Traumatic Thoracic Spinal Cord Contusion
Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)
The purpose of this feasibility study is to compare the impact of Spinal cord stimulation [SCS] for Spinal Cord Injury (SCI) pain and rehabilitation.
- Conditions
- Spinal Cord Injury at T1-T12 Level, Traumatic Thoracic Spinal Cord Contusion, Thoracic Spinal Cord Trauma, Traumatic Thoracic Spinal Cord Laceration
- Trial name
- NCT04894734
- Testing
- EES on, EES off
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nandan Lad, M.D., Ph.D.
Ankylosing Spondylitis
Optimal Adalimumab Plasma Concentrations in Ankylosing Spondylitis Patients
The optimal plasma concentration range of adalimumab in Chinese patients with active ankylosing spondylitis remains unknown, the aims of this study is to determine the concentration-effect relationship, and explore the effect of…
- Trial name
- NCT04875299
- Testing
- The study is observational
- Where
- China
- Volunteers
- 480 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Lumbar Canal Stenosis, Lumbar Spinal Stenosis
Is it Really Necessary Going All Over the Top in Patients With Symptomatic Lumbar Spinal Stenosis?
The goal of this clinical trial is to evaluate the theory of epidural pressure by comparing a surgical procedure that aims to perform less bone resection compared to conventional surgery in patients with lumbar spinal stenosis.
- Conditions
- Lumbar Canal Stenosis, Lumbar Spinal Stenosis, Lumbar Spinal Stenosis (LSS)
- Trial name
- NCT07026305
- Testing
- Pressure-guided laminectomy (PGL), Laminectomy without pressure guidance (LWPG)
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidad Complutense de Madrid
Chronic Pain
Algovita Spinal Cord Stimulation System Hi-Fi Study
The objective of this study is to obtain post-market clinical outcome data for the Algovita SCS System when used on-label, according to the applicable directions for use, using high fidelity tonic stimulation at either ultra-high…
- Trial name
- NCT03622866
- Testing
- Ultra-high pulse width stimulation, Traditional pulse width stimulation
- Where
- 10 sites in United States
- Volunteers
- 20 people
- Sponsor
- Nuvectra
Pain, Postoperative
Different Epidural Initiation Volumes
The aim of this study is to compare the effect of different epidural initiation volumes on postoperative pain scores, local anesthetic requirements, and motor block in patients who undergo patient controlled epidural analgesia…
- Trial name
- NCT03156322
- Testing
- 5 mL epidural initiation volume (bupivacaine + fentanyl), 10 mL epidural initiation volume (bupivacaine + fentanyl), 20 mL epidural initiation volume (bupivacaine + fentanyl)
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Inonu University
Amyotrophic Lateral Sclerosis (ALS)
Olanzapine for the Treatment of Appetite Loss in Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is an adult neurodegenerative disease that is caused by a selective degeneration of the motor nerve cells in the cortex and myelon.
- Trial name
- NCT00876772
- Testing
- Olanzapine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Spinal Cord Injury
Transcutaneous Spinal Cord Stimulation With Robotic Gait Training in Chronic SCI
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment robotic gait training (RGT) to improve functional mobility in participants with chronic spinal cord injuries.
- Trial name
- NCT05921175
- Testing
- RGT+ tSCS + conventional physiotherap, RGT+ conventional physiotherapy
- Where
- Singapore
- Volunteers
- 6 people
- Sponsor
- National University Hospital, Singapore
Refractory Angina Pectoris, Spinal Cord Stimulation
Efficacy of Spinal Cord Stimulation in Patients With Refractory Angina Pectoris
There are a growing number of patients with refractory angina pectoris (RAP). RAP is defined as a 'chronic condition (> three months) characterized by diffuse coronary artery disease in the presence of proven ischemia, which is…
- Trial name
- SCRAP (NCT04915157)
- Testing
- Spinal Cord Stimulator
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Intraoperative Hypotension
HPI Algorithm for the Prevention of IOH During Spinal Surgery [HPIFPIOH]
The aim of this study is to investigate the hypothesis that the use of the Hypotension Prediction Index algorithm (HPI) can reduce intraoperative hypotension (IOH) in adult patients undergoing spinal surgery in the prone position…
- Trial name
- HPIFPIOH (NCT05341167)
- Testing
- HPI algorithm using Edwards device https://www.edwards.com/gb/devices/decision-software/hpi, Vasoactive Agent
- Where
- 2 sites in Greece
- Volunteers
- 85 people
- Sponsor
- Attikon Hospital
Friedreich Ataxia
Patient-reported, Health Economic and Psychosocial Outcomes in Friedreich Ataxia
The PROFA study is an international, multi-centric observational and validation study to assess the patient-reported, psychosocial and economic outcomes of patients with Friedreich Ataxia (FA).
- Trial name
- PROFA (NCT05943002)
- Where
- 6 sites in Austria, France and 1 more
- Volunteers
- 200 people
- Sponsor
- German Center for Neurodegenerative Diseases (DZNE)
Pain, Spinal Cord Injuries
Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation
Pain is one of the most common problems in patients with spinal cord injury (SCI) and persistent pain (that can be of different origin: nociceptive, neuropathic or mixed) is often poorly responsive to pharmacological therapy.
- Trial name
- NCT03170557
- Testing
- Traditional chinese acupuncture, Aspecific needle skin stimulation
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Incomplete Spinal Cord Injury
Powered Exoskeleton Combined With Functional Electrical Stimulation in Clinical Practice
After partial spinal cord injury, gait deficits may be present and often remain even after intensive rehabilitation. New robotic technologies have recently emerged to help augment the extent of rehabilitation.
- Trial name
- NCT04568928
- Testing
- OLTP/PE + FES
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Laval University
Motor Neurone Disease, Hypoxemia and/or Hypercapnia
The Relationship Between Arterial Stiffness and Respiratory Failure in Motor Neurone Disease
Patients with Motor Neurone Disease (MND) admitted to Lane Fox Unit /Royal Brompton Hospital and/or reviewed in Lane Fox Unit /Royal Brompton Hospital clinics and/or outreach review will be approached for participation in the…
- Trial name
- NCT03444428
- Testing
- Non Invasive Ventilation, Without Non Invasive Ventilation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Bleeding, Anemia
Relationship Between Temperature and Intraoperative Bleeding in Patients Undergoing Multilevel Spinal Surgery
The primary objective of this multicentric observational study is to define the role of intraoperative temperature decrease (defined as reduction of at least 1 ° C during surgery) as haemorrhagic risk factor, evaluated as…
- Trial name
- NCT03909711
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Spina Bifida, Sensory Disorder
Sensory and Motor Proficiency For Children With Spina Bifida
Spina bifida is one of the neural tube defects that cause neuromuscular dysfunction. Spina bifida is a disease accompanied by motor paralysis, musculoskeletal problems, Arnold-Chiari malformation, osteoporosis, hydrocephalus…
- Conditions
- Spina Bifida, Sensory Disorder, Motor Disorders, Upper Extremity Dysfunction
- Trial name
- NCT05318677
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Lumbar Spinal Stenosis
EuroPainClinics® Study II (Prospective Trial)
In this prospective multi-centre double-blind trial the effect of the epiduroscopy will be examined in (approximately 300) adult patients with low back pain pain caused by failed back surgery syndrome (FBSS).
- Trial name
- EPCSII (NCT02459392)
- Testing
- Epiduroscopy, Hyaluronic Acid, DepoMedrol
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- EPC Education s.r.o.
Hip Fractures, Acute Post Operative Pain
PENG vs SIFI Block for Positioning Pain During Spinal Anesthesia
This study aims to compare the effectiveness of preoperative ultrasound-guided suprainguinal fascia iliaca compartment block (SFICB) and pericapsular nerve group block (PENG) in preventing positioning pain during spinal…
- Conditions
- Hip Fractures, Acute Post Operative Pain, Nerve Block, Spinal Anesthesia
- Trial name
- NCT05549011
- Testing
- PENG Block, SIFI compartment block, Numeric Rating Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
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