Clinical trials: Spinal
Disc Herniation
Silent Lumbar Disc Herniation Syndrome
LDH is a common phenomenon that is often described in association with various pathological processes affecting the neuromuscular and locomotor systems.
- Trial name
- NCT06453499
- Testing
- Physical therapy
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Noha Khaled Shoukry
Lumbar Disc Herniation, Radiculopathy Lumbar
Efficacy and Safety of Electroacupuncture on Lumbar Disc Herniation with Radiculopathy
Lumbar disc herniation with radiculopathy (LDHR) is the local displacement of the intervertebral disc and its contents beyond the edge of the normal intervertebral disc space, resulting in pain, weakness or numbness in the muscle…
- Trial name
- NCT06611332
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Arthritis, Psoriatic
A Study of Guselkumab in Participants With Active Psoriatic Arthritis
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
- Trial name
- APEX (NCT04882098)
- Testing
- Guselkumab
- Where
- 280 sites in United States, Australia and 27 more
- Volunteers
- 1,054 people
- Sponsor
- Janssen Research & Development, LLC
Idiopathic Adolescent Scoliosis, Scoliosis Idiopathic
Effects of Core Stabilization Exercises and Rotation Angular Breathing Exercises Among Idiopathic Scoliosis Patients
This study is a single-blind, two-arm parallel-group randomized controlled trial designed to evaluate the effects of core stabilization exercises combined with rotational angular breathing exercises on adolescents with idiopathic…
- Trial name
- CSE RAB IS (NCT07601893)
- Testing
- Core Stabilization Exercises, Standard Care (in control arm)
- Where
- 2 sites in Pakistan
- Volunteers
- 32 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Degenerative Disc Disease
Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fiber Device Compared to Titanium Devices in Patients Undergoing Spinal Arthrodesis for Degenerative Spinal Diseases
Previous clinical study carried out on cancer patients at IOR Spine Surgery (approved in October 2014). The carbon device is indicated in patients suffering from vertebral tumors who need stabilization and will then carry out…
- Trial name
- NCT06209684
- Testing
- Titanium, Carbofix
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Istituto Ortopedico Rizzoli
Spinal Stenosis of Lumbar Region, Spine Degeneration
Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis
Background Lumbar spinal stenosis (LSS) is a common condition characterized by spinal canal narrowing, often linked to ligamentum flavum hypertrophy (LFH) and degeneration.
- Trial name
- APIDeLeG (NCT07026552)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Peripheral Neuropathy Due to Chemotherapy
Closed Loop Spinal Cord Stimulation for Chemotherapy Induced Peripheral Neuropathy, a Pilot Study.
To explore the benefits of using closed loop spinal cord stimulation (SCS) in the treatment of patients experiencing painful chemotherapy induced peripheral neuropathy (CIPN) by assessing changes in pain, quality of life, pain…
- Trial name
- NCT06616649
- Testing
- Spinal cord stimulator implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Endotracheal Intubation
Intubation During Spinal Immobilization
The aim was to evaluate the performance of the C-MAC compared with Macintosh when performed in patients with immobilized cervical spine by unexperienced physicians.
- Trial name
- NCT02733536
- Testing
- Standard endotracheal tube, C-MAC
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Spinal Cord Injury, Cerebral Palsy
Experimental Evaluation of Wheelchair-Mounted Robotic Arms
Researchers from the University of South Florida's Rehabilitation Engineering program are looking for volunteers to participate in a research study for experimental evaluation of wheelchair-mounted robotic arms (WMRAs).
- Conditions
- Spinal Cord Injury, Cerebral Palsy, Multiple Sclerosis
- Trial name
- HRI (NCT01652352)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Spinal Cord Injuries
Reactive Stepping Training in Individuals With Spinal Cord Injury
Falling is common among individuals with incomplete spinal cord injury (iSCI), with most falls occurring while walking. Falls result in injuries (e.g., broken bones), hospital readmission, and reduced participation in work and…
- Trial name
- NCT02960178
- Testing
- Perturbation-based training, Conventional walking training
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injury, Chronic Inflammation
Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury
SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors…
- Conditions
- Spinal Cord Injury, Chronic Inflammation, Glucose Metabolism, Endothelial Function
- Trial name
- SCIPHS (NCT04971408)
- Testing
- passive heat stress, Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Lumbar Disc Herniation
Strengthening Exercise and Activities of Daily Living Instructions for Patients With Lumbar Disc Herniation
Lumbar disc herniation (LDH) is one of the most common causes of mechanical low back pain (LBP) associated with radiating leg pain.
- Trial name
- NCT05021718
- Testing
- Strengthening exercises, Pharmacological therapy, Hot compression
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Chittagong Medical College
Radiculopathy, Myelopathy
Pivotal IDE Study of the BRYAN(R) Cervical Disc Prosthesis in the Treatment of DDD Versus ACDF
The purpose of this study is to establish the safety and effectiveness of the BRYAN(R) Cervical Disc Prosthesis in treating single-level degenerative disc disease of the cervical spine.
- Conditions
- Radiculopathy, Myelopathy, Cervical Degenerative Disc Disease
- Trial name
- NCT00437190
- Testing
- ATLANTIS™ Cervical Plate System and allograft, BRYAN Cervical Disc Prosthesis
- Where
- 38 sites in United States
- Volunteers
- 494 people
- Sponsor
- Medtronic Spinal and Biologics
Crohn Disease, Ulcerative Colitis
National Observational Study On The Use Of Inflectra™ An Infliximab Biosimilar In Real Life
National, prospective, multicentre observational study designed for eligible patients treated with Inflectra. Its objectives are to describe under real conditions of use, the profile of patients treated with Inflectra and the…
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- ReFLECT (NCT02925338)
- Testing
- QOL questionaire
- Where
- 67 sites in France
- Volunteers
- 1,431 people
- Sponsor
- Pfizer
Multiple Sclerosis, Myasthenia Gravis
Serum Auto-Antibodies in Neurological Diseases
Under normal conditions our immune system protects us against infections and tumors. The immune system does this by recognizing that the infecting organism or the tumor is foreign to the body and attacking it.
- Conditions
- Multiple Sclerosis, Myasthenia Gravis, Transverse Myelitis
- Trial name
- SAA (NCT00704626)
- Testing
- Blood Draw, Cheek swab
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Davis
Cesarean Section Complications, Spinal Anesthesia
Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia
Comparison between prophylactic continuous variable infusion of phenylephrine (starting dose 0,5mcg/kg/min) and norepinephrine tartrate (starting dose 0,1mcg/kg/min) to prevent hypotension and maintain cardiac output under spinal…
- Trial name
- PHENAD (NCT03849508)
- Testing
- Norepinephrine, Phenylephrine
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Spinal Cord
Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord
To learn if MRS can effectively assess spinal cord lesions.
- Trial name
- NCT06548776
- Testing
- Magnetic Resonance Spectroscopy (MRS) Scan
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Spina Bifida, Cerebral Palsy
Assessing Transition Practices for Children With Disabilities: Pathways to a Successful Adulthood
Transition to adult care is a purposeful and structured movement of youth with complex disabilities from child centered to adult oriented services. This complex and potentially challenging period requires careful planning.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Spastic Paraplegia
- Trial name
- NCT07706517
- Testing
- Chart review, Semi-structured interview
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pressure Injuries, Spinal Cord Injuries (SCI)
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries
Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden.
- Conditions
- Pressure Injuries, Spinal Cord Injuries (SCI), Traumatic Brain Injury
- Trial name
- NCT07493889
- Testing
- High-Voltage Monophasic Pulsed Current Electrical Stimulation, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Hypotension Drug-Induced
Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia
To compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : Hemodynamic and kidney function .
- Trial name
- NCT03478618
- Testing
- Lactated Ringer
- Volunteers
- 60 people
- Sponsor
- Assiut University
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