Clinical trials: Spinal
Friedreich Ataxia
FRDA Investigator Initiated Study (IIS) With Elamipretide
To evaluate the safety, tolerability, and activity of Elamipretide in treating vision loss in Friedreich Ataxia (FRDA).
- Trial name
- ELViS-FA (NCT05168774)
- Testing
- Elamipretide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Spondylitis, Ankylosing
Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA
The purpose of this study is to study the benefits and risks of etanercept withdrawal in patients who have achieved a significant clinical response.
- Trial name
- RE-EMBARK (NCT02509026)
- Testing
- Etanercept
- Where
- 82 sites in United States, Australia and 12 more
- Volunteers
- 210 people
- Sponsor
- Pfizer
Catheter Infections, Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation
Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch
Joint replacement is becoming an increasingly common procedure. In 2005, 534,000 total knee arthroplasties (TKA) were performed in the United States which is at a rate of 18.1 per 10,000 individuals, and the demand for primary…
- Trial name
- NCT01411891
- Testing
- Chlorhexidine impregnated patch (Biopatch)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Spinal Cord Injury, Muscle Spasticity
Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs.
- Trial name
- NCT00041717
- Testing
- Fampridine-SR
- Where
- 45 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Acorda Therapeutics
Constipation, Fecal Incontinence
A Colonic Tube to Improve Bowel Function in Spinal Cord Injury
The investigators want to know if placing a tube through the skin and into the colon to flush out the colon is safe and effective in helping spinal cord Veterans with bowel management.
- Conditions
- Constipation, Fecal Incontinence, Spinal Cord Injury
- Trial name
- NCT00345397
- Testing
- Percutaneous endoscopic colostomy (PEC) tube
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
High Frequency SARS for Neurogenic Bladder and Bowel Emptying
The purpose of this study is to determine if bladder emptying can be achieved using stimulation of the sacral roots at certain frequencies. Neurogenic bladder dysfunction occurs after spinal cord injury (SCI).
- Trial name
- SARS600 (NCT05214378)
- Testing
- Finetech-Brindley Sacral Anterior Roots Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Brain Tumors, Spinal Cord Tumors
Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma
The goal of this clinical research study is to learn if lapatinib when given in combination with temozolomide can help to control ependymoma that has come back after treatment. The safety of this combination will also be studied.
- Trial name
- NCT00826241
- Testing
- Temozolomide, Lapatinib
- Where
- 6 sites in United States
- Volunteers
- 58 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Arthritis, Psoriatic
Remicade Study in Psoriatic Arthritis Patients Of Methotrexate-Naïve Disease (RESPOND) (Study P04422)
This study is undertaken to compare the efficacy and onset of action of infliximab plus methotrexate (IFX + MTX) versus methotrexate alone (MTX) in methotrexate naïve active psoriatic arthritis patients.
- Trial name
- NCT00367237
- Testing
- Infliximab + methotrexate (IFX + MTX), Methotrexate (MTX)
- Volunteers
- 115 people
- Sponsor
- Merck Sharp & Dohme LLC
Spinal Cord Injuries, Obesity
Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI
The purpose of this research is to examine changes in blood glucose control and metabolism in individuals with SCI and non injured controls at rest and during exercise after five days of exposure to IH.
- Conditions
- Spinal Cord Injuries, Obesity, Insulin Resistance
- Trial name
- NCT02973438
- Testing
- Intermittent Hypoxia (IH)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injuries
Spinal Cord Injury Program in Exercise
The purpose of this study is to examine two 8-week, remotely delivered exercise interventions: Movement-to-Music (M2M) and Standard Exercise Training (SET), with 327 adults with spinal cord injury.
- Trial name
- SCIPE (NCT03925077)
- Testing
- Movement-to-Music, Standard Exercise Training
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Alabama at Birmingham
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS)
This is a phase II study to determine the safety and tolerability of ILB®, a type of low molecular weight dextran sulfate, in patients with Motor Neurone Disease (MND)/ Amyotrophic Lateral Sclerosis (ALS)
- Trial name
- ALS (NCT03705390)
- Testing
- ILB®
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Birmingham
Scoliosis, Pain
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients
Acute pain management following major surgical procedures in pediatric patients continues to be a challenge, especially after extensive posterior spine fusions.
- Trial name
- NCT02558010
- Testing
- Methadone, Normal Saline, Morphine
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Medical College of Wisconsin
Pressure Ulcers, Spinal Cord Injury
Comparison of HP011-101 to Standard Care for Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury
The trial will compare the effects of 14 days treatment with HP011 101 versus Standard Care in subjects with Stage I or II pressure ulcers as a complication of spinal cord injury, measured as change from baseline in composite…
- Trial name
- NCT01433159
- Testing
- HP011-101 (Xenaderm Ointment), Standard Care
- Where
- 5 sites in United States
- Volunteers
- 19 people
- Sponsor
- Healthpoint
Spinal Cord Injury Cervical
Access-H20 Faucet for Spinal Cord Injury
The Phase I SBIR objective is to design, develop \& demonstrate feasibility of Access-H2OTM, a sensor driven smart faucet to enable and empower independent drinking and grooming for individuals impacted by spinal cord injury…
- Trial name
- NCT06159946
- Testing
- Access-H2O faucet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Spinal Anaesthesia, Ultrasound
A Trial on Ultrasound-assisted Spinal Anaesthesia
A randomised controlled trial comparing the use of pre-procedural ultrasound scanning with manual palpation to identify landmarks for performance of spinal anaesthesia.
- Trial name
- NCT01699373
- Testing
- Ultrasound scan
- Where
- Singapore
- Volunteers
- 170 people
- Sponsor
- Changi General Hospital
Osteoporotic Fractures, Spinal Fractures
Build Better Bones With Exercise
The long-term goal of our research team is to conduct a large multicentre study to evaluate whether tailored home exercise can prevent fractures in high-risk individuals.
- Trial name
- B3E (NCT01761084)
- Testing
- Exercise and behaviour change strategies
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- University of Waterloo
Lower Limb Surgery
Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery
The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia
- Trial name
- NCT02201784
- Testing
- Levobupivacaine, Ropivacaine
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Aligarh Muslim University
Spinal Cord Injury
Body Temperature in Persons With Tetraplegia When Exposed to Heat
The deleterious effects of hyperthermia are well appreciated in able-bodied persons. However, the consequences of impaired regulation of normal body temperature on cognitive performance of persons with tetraplegia is not known.
- Trial name
- NCT01890915
- Testing
- Heat Exposure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Axial Spondyloarthritis
A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment
A study comparing a treat-to-target (T2T) intense treatment approach with routine treatment (Standard of Care [SOC]) in reducing disease activity in participants with axial spondyloarthritis (axSpA).
- Trial name
- STRIKE (NCT02897115)
- Testing
- Adalimumab, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Volunteers
- 22 people
- Sponsor
- AbbVie
Inflammatory Bowel Diseases
Regulation of Mucosal Healing in Inflammatory Bowel Disease
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid…
- Trial name
- NCT04504136
- Testing
- Serial Biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Terrence A Barrett
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