Clinical trials: Spinal
Intervertebral Disk Degeneration
Patient Positioning in Lumbar Fusion Surgery and Its Impact on Spinal Sagittal Balance and Surgeon Satisfaction
This is a parallel, randomized controlled trial comparing two types of patient positioning and their effect on radiologic measures (pre-surgery visit, in the operating room prior to surgery, at the conclusion of surgery, and at 3…
- Trial name
- NCT01326091
- Testing
- Hyperlordotic Positioning
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Amyotrophic Lateral Sclerosis
Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases.
This registry study aims to collect data on the provision of assistive devices, medicines, and other healthcare measures, such as ventilation therapy and nutrition support, in patients with Amyotrophic lateral sclerosis (ALS)…
- Trial name
- NCT05852418
- Where
- 16 sites in Germany
- Volunteers
- 25,000 people
- Sponsor
- Ambulanzpartner Soziotechnologie APST GmbH
Motor Disorders, Gait Disorders, Neurologic
Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population
In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990.
- Conditions
- Motor Disorders, Gait Disorders, Neurologic, Neurodegenerative Diseases, Spinal Cord Injuries
- Trial name
- ALERT (NCT06538974)
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Wandercraft
Amyotrophic Lateral Sclerosis
Online Self-Compassion Course for pALS (Compassion pALS)
This study is designed to be a pragmatic, single-arm trial to evaluate the efficacy, implementation, and feasibility of an online ALS-specific self-compassion training program to enhance self-compassion and improve quality of…
- Trial name
- NCT05202743
- Testing
- Observational for ALS patients
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Cesarean Section, Anesthesia, Spinal
Intrathecal Dexmedetomidine vs Epinephrine
Several studies have shown that adding dexmedetomidine or epinephrine to single-dose spinal analgesia preparations improves the length and/or speed of onset of the sensory block and post-operative pain management without…
- Trial name
- NCT06418308
- Testing
- Dexmedetomidine, Epinephrine, Standardized Spinal Mixture
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pain Management
BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management…
- Trial name
- NCT07659743
- Testing
- Active BreEStim Treatment, The TENS Treatment
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The University of Texas Health Science Center, Houston
Polio
Inactivated Poliovirus Vaccine (IPV) With or Without E.Coli Double Mutant Heat-Labile Toxin (dmLT) Challenge Study in Healthy Adults
In this study, the safety and tolerability of inactivated polio vaccine (IPV) co-administered with dmLT will be assessed, as well as whether co-administration of dmLT with IPV enhances mucosal responses compared to those with IPV…
- Trial name
- NCT04232943
- Testing
- Inactivated Poliomyelitis Vaccine (IPV), E.coli Double Mutant Heat-Labile Toxin (dmLT) (adjuvant), Bivalent Oral Polio Vaccine (bOPV)
- Where
- Belgium
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- PATH
Muscular Atrophy, Spinal
A Study to Collect Blood Samples From Patients With Spinal Muscular Atrophy for Biomarker Analysis
In this single center study blood samples for biomarker analysis will be collected from patients with spinal muscular atrophy. Up to 21 mL blood will be drawn from eligible patients at a single visit.
- Trial name
- NCT01910168
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche
Spinal Cord Injury
Acupuncture for Treatment of Acute Spinal Cord Injury: an Exploratory/Developmental Study
Specific Aim: to implement and evaluate a research protocol for demonstrating the efficacy of Acupuncture Therapy to improve neurological recovery after incomplete SCI compared to a control protocol.
- Trial name
- NCT00432289
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Craig Hospital
Ankylosing Spondylitis
Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis
The purpose of this study is to compare efficacy, pharmacokinetics, and safety of investigational formulations of etanercept administered as 50 mg once weekly with 25 mg twice weekly and placebo in patients with ankylosing…
- Trial name
- NCT00418548
- Testing
- Etanercept
- Volunteers
- 350 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Musculoskeletal Pain, Flexibility
Effects of a Four-Week Active Break Program on Musculoskeletal Pain and Spinal Mobility in Office Workers
This study was designed as a two-arm, parallel-group randomized controlled trial with a 1:1 allocation ratio. A total of 55 office workers were randomly allocated to an experimental group (n = 28) or a control group (n = 27).
- Conditions
- Musculoskeletal Pain, Flexibility, Well Being
- Trial name
- NCT07865143
- Testing
- Active Break
- Where
- Slovenia
- Volunteers
- 55 people
- Sponsor
- Julia Wegener
Amyotrophic Lateral Sclerosis
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis
In this proposed study, the investigators will evaluate the safety and efficacy of lipoic acid in treatment of Amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT04518540
- Testing
- lipoic acid group, control group
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ankylosing Spondylitis
Efficacy of Myofascial Release in Patients With Axial Spondyloarthritis.
Axial spondyloarthritis (AS), is a chronic and disabling disease that mainly affects young people, generating clear limitations in mobility and functional capacity in patients who develop this disease.
- Trial name
- NCT04424589
- Testing
- Myofascial release
- Volunteers
- 82 people
- Sponsor
- Universidad de la Sabana
Radical Prostatectomy, Postoperative Pain
Postoperative Pain, Recovery and Discharge Following Robot-assisted Laparoscopic Prostatectomy
Prostate cancer is the commonest cancer form in men in Northern Europe. Management of the cancer often includes surgical removal of the primary tumor.
- Trial name
- RAPID (NCT03639389)
- Testing
- Bupivacaine, Analgesics
- Where
- 2 sites in Sweden
- Volunteers
- 211 people
- Sponsor
- Karolinska Institutet
Optic Nerve Sheath Diameter
Effect of Different Positive End-Expiratory Pressure (PEEP) Levels on Optic Nerve Sheath Diameter
The goal of this prospective observational study is to evaluate the effects of different PEEP values on the optic nerve sheath diameter (ONSD), a noninvasive indicator of intracranial pressure (ICP), in patients undergoing…
- Trial name
- NCT07085949
- Testing
- 5 cmH2O PEEP, 10 cmH2O PEEP
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Izmir City Hospital
Spinal Degenerative Disorder, Spinal Stenosis
Physical Activity Intervention for Patients Following Lumbar Spine Surgery
There is a critical need to target physical activity during postoperative management to optimize long-term recovery after lumbar spine surgery.
- Conditions
- Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
- Trial name
- PASS (NCT04591249)
- Testing
- Physical activity intervention, Usual care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Spinocerebellar Ataxia 3
Clinical Effects of Oral Trehalose In Patients With Spinocerebellar Ataxia 3
There are no clinically established treatments which have been proven to delay the disease progression in spinocerebellar ataxia (SCA) 3.
- Trial name
- NCT04426149
- Testing
- trehalose
- Where
- Malaysia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Low Back Pain
Interventional Study of Effects on Spine Height With Two Unloading Positions
The purpose of this study is to test a physical therapy intervention for reducing pain in the low back and into the legs. With individuals over the age of 40 years, this pain may be associated to changes in back height from aging…
- Trial name
- NCT01048749
- Testing
- aquatic vertical suspension., land-based supine flexion
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Texas Tech University Health Sciences Center
Spine Osteoarthritis, Spa Resorts
Effectiveness of Spa Treatment, Outpatient Physiotherapy and no Physiotherapy in Spine Osteoarthritis
In the first study group will participate patients with spine osteoarthritis who will be treated in polish spas in Subcarpathian Region. Complex physiotherapy including balneotherapy will be applied in study group participants.
- Trial name
- NCT03974308
- Testing
- Comprehensive physiotherapy including balneotherapy and filling questionaire, Comprehensive physiotherapy without balneotherapy and filling questionaire, No intervention, only filling questionaire
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- University of Rzeszow
Inflammatory Bowel Diseases
Azathioprine Linked With Impaired Intestinal Epithelial Postoperative Regeneration in Crohn's Disease
What is known? the impact of AZA, immunomodulatory drug widely used in active CD, on the intestinal wall differs from those of steroids, what is reflected in the significant difference in the postoperative anastomotic leaks rate…
- Trial name
- NCT05456776
- Volunteers
- 35 people
- Sponsor
- Centre of Postgraduate Medical Education
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