Clinical trials: Spinal
Degenerative Disc Disease, Chronic Low-back Pain
Post Market Observational Trial for the PerQdisc Nucleus Replacement Device
PerQdisc PMCF1 is a post-market clinical follow-up observational trial to follow subjects receiving a PerQdisc spinal implant for a duration of 5 years.
- Trial name
- PMCF1 (NCT05105490)
- Testing
- PerQdisc
- Where
- Germany
- Sponsor
- Spinal Stabilization Technologies
Cervical Intervertebral Disc Disease, Cervical Spinal Stenosis
Prospective Observation of the Fluoroscopy-guided Cervical Epidural Approach Using the Contralateral Oblique View
The aim of the present study is to investigate the safety and clinical utility of contralateral oblique view for fluoroscopic guided cervical epidural access.
- Conditions
- Cervical Intervertebral Disc Disease, Cervical Spinal Stenosis, Cervical Radicular Pain, Herpes Zoster
- Trial name
- NCT04774458
- Testing
- Fluoroscopic-guided cervical epidural access
- Where
- South Korea
- Volunteers
- 439 people
- Sponsor
- Asan Medical Center
Inguinal Hernia, Nausea
Intrathecal Morphine for Inguinal Hernia Repair.
The aim of this study was to compare the effects of two different doses of intrathecal morphine (0.1 mg and 0.4 mg) combined with 7.5 mg of heavy bupivacaine on postoperative block regression times, postoperative analgesia and…
- Conditions
- Inguinal Hernia, Nausea, Vomiting, Pruritus
- Trial name
- NCT02001948
- Testing
- intrathecal morphine 0.1 mg combined with intrathecal heavy bupivacaine 7.5 mg, intrathecal morphine 0.4 mg combined with intrathecal heavy bupivacaine 7.5 mg, standard monitoring with Datex Ohmeda anesthesia monitor, GE, Finland
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ankara University
Fecal Incontinenece
A Double Blinded Study to Examine the Effect of Coated Suppositories on Fecal Incontinence in Patients With Spinal Cord Injury
This is a double blinded cross over study. Approximately 20 spinal cord injury patients will be participating in this 4 weeks study.The primary outcome is difference in fecal incontinence as recorded in diaries, between the…
- Trial name
- NCT01297608
- Testing
- caoted suppository, coated suppository
- Where
- Israel
- Sponsor
- RDD Pharma Ltd
Labor Pain, Pain
The Effects of Intermittent Epidural Bolus on Fever During Labor Analgesia
Epidural analgesia is associated with maternal intra-partum fever during labor. Intermittent epidural injections appear to reduce the incidence of maternal intra-partum fever compared to continuous epidural infusion during labor…
- Conditions
- Labor Pain, Pain, Neurologic Manifestations, Signs and Symptoms
- Trial name
- EIEBFLA (NCT01708668)
- Testing
- Epidural analgesia, Combined spinal-epidural analgesia, Continuous epidural infusion
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- ShanWu Feng, M.D.
Poliomyelitis
Fractional Inactivated Poliovirus Vaccine Booster and Rotavirus Study
This is an open-label phase IV, randomized controlled trial of inactivated poliovirus vaccine (IPV) and rotavirus vaccines. This trial will assess immunogenicity of a booster dose of fractional IPV (fIPV) in comparison with a…
- Trial name
- fIPV (NCT02847026)
- Testing
- IPV at 14 and 22 weeks of age, Rotarix, IPV at 14 and 22 weeks of age, RotaTeq, IPV at 14 and fIPV at 22 weeks, Rotarix
- Where
- Bangladesh
- Volunteers
- 1,144 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Ankylosing Spondylitis
A Study to Evaluate the Efficacy and Safety of Bimekizumab in Subjects With Active Ankylosing Spondylitis
The purpose of the study is to demonstrate the efficacy, safety and tolerability of bimekizumab administered subcutaneously (sc) compared to placebo in the treatment of subjects with active ankylosing spondylitis (AS).
- Trial name
- BE MOBILE 2 (NCT03928743)
- Testing
- Bimekizumab
- Where
- 83 sites in United States, Belgium and 12 more
- Volunteers
- 332 people
- Sponsor
- UCB Biopharma SRL
Spinal Cord Injury
Coronary Artery Calcification Score and Risk Factors for Coronary Artery Disease in Persons With Spinal Cord Injury
Although conventional risk factors for coronary heart disease (CHD) have been identified and routinely used to determine risk for CHD in the general population, a systematic approach to determine population-specific risk for CHD…
- Trial name
- CAC (NCT02007226)
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Cerebral Palsy, Spastic
Multidimensional Approach in Patients With Severe Cerebral Palsy, Prospective Cohort(MAPCP Cohort)-Offline
In children with cerebral palsy, secondary problems lead to hip dislocation and scoliosis. But There is no definite evidence for the dislocation of hip and scoliosis.
- Trial name
- NCT03677843
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ju Seok Ryu
Spinal Cord Injuries, Neuropathic Pain
Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury
Many adults with spinal cord injury (SCI) suffer from long-term debilitating neuropathic pain. Available treatments, including opioids, are ineffective at eliminating this pain.
- Trial name
- NCT04706208
- Testing
- Cognitive Multisensory Therapy, Usual Care, Clinical Assessment
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depression, Postpartum, Labor Pain
CSE v. Epidural for Postpartum Depression
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms.
- Trial name
- COPE (NCT03022526)
- Testing
- CSE, Epidural, Bupivacaine / fentaNYL
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Disc Degenerative Disease, Spondylolisthesis
A Clinical Study of a Spine Fusion System in Vertebral Body Fusion Surgery
The primary objective of this study is to demonstrate that the efficacy and safety of Spine fusion system manufactured in China is no inferior than imported product.
- Conditions
- Disc Degenerative Disease, Spondylolisthesis, Spinal Fracture, Spinal Deformity
- Trial name
- NCT02252185
- Testing
- Johnson&Johnson Medical Suzhou made Spine Fusion System, Imported EXPEDIUM screws and OPAL cage
- Where
- 8 sites in China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Medical (Suzhou) Ltd.
Spinal Cord Injury
Effects of Wheelchair Treadmill and Conventional Exercises on Trunk Balance in Spinal Cord Injury Patients
This study aims to determine whether wheelchair treadmill exercises improve trunk balance and stability compared to conventional wheelchair exercises.
- Trial name
- NCT06876285
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Muscular Atrophy, Spinal
A Study of Dosing Patterns and Costs in Patients With Spinal Muscular Atrophy Receiving Disease Modifying Therapies
The aim of this study was to assess real-world dosing patterns, long-term healthcare costs, and characteristics of SMA patients who received treatment with DMTs. DMTs included onasemnogene abeparvovec, nusinersen, and risdiplam.
- Trial name
- NCT07378943
- Where
- United States
- Volunteers
- 4,114 people
- Sponsor
- Novartis Pharmaceuticals
Adolescent Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis (AIS) Patient Positioning in EOS System®
The EOS® imaging system, a new imaging modality which offers low dose, weight bearing and full body X-ray imaging, requires a new standing position where patients put their hands and forearms on the wall vertically for stability.
- Trial name
- NCT02269657
- Testing
- EOS® imaging system
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Children's Hospital of Philadelphia
Lumbar Puncture
The First Puncture Success Rate of a Novel Injeq IQ-Tip™ System in Pediatric Lumbar Punctures
The investigation aims to demonstrate the first puncture success rate, as proxy of clinical benefit and clinical performance, of bioimpedance spectroscopy based spinal needle guidance method among pediatric hemato-oncology…
- Trial name
- IQ-LP-03 (NCT04070144)
- Testing
- IQ-Tip(tm) system
- Where
- 3 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Injeq Ltd
Spinal Cord Injuries
Brain Monitoring, tDCS and Robotic Training in SCI
To explore the neurophysiological and electroencephalography (EEG) changes that one single session of tDCS and robotics has in the SCI population (Study 1); and to investigate upper limb motor recovery in chronic tetraplegia SCI…
- Trial name
- NCT06813287
- Testing
- Electroencephalography (EEG), Upper extremity robot
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Kathleen Friel
Spinal Degenerative Disorder
Telehealth Activity Intervention After Lumbar Spine Surgery
The overall objective of this randomized controlled study is to examine the preliminary efficacy of a physical activity intervention that includes wearable technology and remote physical therapist support in patients undergoing…
- Trial name
- PASS (NCT04968821)
- Testing
- Physical activity intervention, Usual care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Spinal Cord Injury Cervical
Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial
This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life.
- Trial name
- NCT06903416
- Testing
- Transcutaneous Cervical Spinal Cord Stimulation, Paired Corticospinal Motoneuronal Stimulation, Functional Task Practice
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Spinal Cord Neoplasm
Validation of Pre-clinical Nano-Based Analgesics in Cells From Human Dorsal Root Ganglia
This study investigates the pre-clinical nano-based analgesics in cells from human dorsal root ganglia (clusters of neurons). Collecting these neurons may help future research related to safe and effective pain treatment.
- Trial name
- NCT04533919
- Testing
- Biospecimen Collection
- Sponsor
- M.D. Anderson Cancer Center
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