Clinical trials: Spinal
Spondyloarthritis, Rheumatoid Arthritis
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
The primary objective of the study aims to compare the biodiversity of intestinal microbiota between spondylarthritis (SPA) or rheumatoid arthritis (RA) patients and healthy volunteers, by microbiota DNA sequencing in order to…
- Trial name
- MICROBIART (NCT04292067)
- Testing
- Faecal sampling, Blood sampling
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Cord Injuries (SCI), Detrusor Overactivity
The Effectiveness of Transcutaneous Sacral Neuromodulation Techniques-Magnetic Stimulation and Electrical Stimulation-on Detrusor Overactivity in Patients With Spinal Cord Injury
The goal of this prospective, randomized clinical trial is to compare the efficacy and safety of transcutaneous sacral magnetic stimulation versus sacral electrical stimulation for detrusor overactivity in 40 male and female…
- Trial name
- NCT07578532
- Testing
- Transcutaneous Sacral Electrical Stimulation, Transcutaneous sacral magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Diphtheria, Tetanus
Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand
The present clinical study will assess the immunogenicity and reactogenicity of Sanofi Pasteur's DTacP-IPV// PRP~T combined vaccine (Pentavac™ or Pentaxim™) as a three-dose primary vaccination at 2, 4, and 6 months of age…
- Conditions
- Diphtheria, Tetanus, Poliomyelitis, Haemophilus Infections
- Trial name
- NCT00255021
- Testing
- Diphtheria, Tetanus, Polio, Acellular Pertussis and Hib Vac
- Where
- Thailand
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Sanofi
Spine Metastases
Prophylactic Radiotherapy of MInimally Symptomatic Spinal Disease
Early palliative care has been shown to improve the quality of life and even survival for patients with metastatic cancer. More and more supportive oncology teams in cancer centers now advocate for early integration of radiation…
- Trial name
- PROMISSeD (NCT05534321)
- Testing
- Prophylactic Radiotherapy, Standard of care systemic therapy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Baptist Health South Florida
Axial Spondyloarthritis
Add-on Therapy for Axial Spondyloarthritis
Rationale: Recent investigations suggest that, through certain concentration/meditation techniques, it is possible to modulate autonomic activity.
- Trial name
- NCT02744014
- Testing
- Add-on Therapy for Axial Spondyloarthritis
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pain, Postoperative
Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .
Analgesia in liver surgery is a challenge, postoperative coagulopathy risk raises fears an epidural haematoma formation following the epidural analgesia, "gold standard" in major abdominal surgery.
- Trial name
- CATHEPAT (NCT03238430)
- Testing
- intrathecal morphine, Morphine PCA, Ropivacaine infiltration
- Where
- France
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Degenerative Disc Disease
Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel
Degenerative disc disease (DDD) refers to a syndrome in which a degenerating disc causes chronic back pain, significantly impacting an individual's ability to function.
- Trial name
- NCT01028300
- Testing
- ProDisc™-L Total Disc Replacement (TDR)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Synthes USA HQ, Inc.
Muscular Atrophy, Spinal
A Real-World Study of Clinical Use of Available Treatments for Pediatric Patients With Spinal Muscular Atrophy
The aim of this study was to evaluate real-world treatment patterns and clinical outcomes in pediatric SMA patients in the Czech and Slovak Republics, using data from the Registry of muscular Dystrophy (REaDY).
- Trial name
- NCT07474311
- Where
- Czechia
- Volunteers
- 213 people
- Sponsor
- Novartis Pharmaceuticals
Scoliosis Patients
Hemoglobin Monitoring in Scoliosis Surgery
The study is planned to include patients who will undergo elective scoliosis surgery under general anesthesia at the Health Sciences University Antalya Education and Research Hospital.
- Trial name
- NCT07054411
- Testing
- Radical-7 Pulse CO-Oximeter
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Erhan Ozyurt
Friedreich Ataxia
Digital Outcome Assessment Using AI Active Gaming and Motion Capture in Friedreich Ataxia
Friedreich ataxia (FA) is a rare, inherited condition that progressively affects balance, coordination, and walking. Clinical trials of new FA treatments rely largely on standard clinical rating scales, but these can be tiring…
- Trial name
- STEP-OUT FA (NCT07731971)
- Testing
- Laboratory validation session (VSimulator), Home-based active gaming assessment
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Chronic Subdural Hematoma
Spinal CSF Leaks in Chronic Subdural Hematoma
Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8/100.000.
- Trial name
- SPICE (NCT06323434)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Freiburg
Phenylephrine
Anxiety and Phenylephrine Dosage
Spinal anesthesia is considered gold standard anesthetic technique of choice for cesarean delivery (1). However its use is frequently associated with maternal hypotension, which occurs in up to 71% of cases, without prophylactic…
- Trial name
- NCT03696732
- Testing
- Anxiety questionnaire, VAS questionnaire
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Degenerative Disc Disease, Spinal Stenosis
Effectiveness of Lumbar Fusion When NanOss Bioactive Is Used With Posterolateral Gutter Fusions
Spine fusion is one of the most common procedures performed in spinal surgery. Several surgical techniques can achieve a solid union, but the intertransverse posterolateral fusion (PLF) is the most widely used.
- Conditions
- Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT01452516
- Testing
- nanOss Bioactive Bone void filler, Interbody FCage
- Where
- 7 sites in United States
- Volunteers
- 28 people
- Sponsor
- Pioneer Surgical Technology, Inc.
Spinal Cord Injuries
KAFO Orthoses Versus the ABLE Exoskeleton
This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting.
- Trial name
- NCT04855916
- Testing
- ABLE Exoskeleton, KAFO Orthosis
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Chronic Pain
Effectiveness and Safety of Implantable Neurostimulation Systems for Chronic Pain: A Spanish Multicenter Study (STIM-RENASED)
Chronic pain is a prevalent condition that negatively affects patients' quality of life. Implantable neurostimulation therapies have been proposed as a treatment option for chronic pain.
- Trial name
- STIM-RENASED (NCT05770700)
- Where
- 16 sites in Spain
- Volunteers
- 504 people
- Sponsor
- Sociedad Espanola del Dolor
Spinal Nerve Root Disorder Nos
Concurrent Treatment for Patients With Cervical Radiculopathy
This study evaluates the effectiveness of two treatment interventions in patients with cervical radiculopathy. One group will receive a concurrent approach using traction and neuromobilizations.
- Trial name
- NCT03636009
- Testing
- concurrent traction and neuromobilization technique, sequential traction and neuromobilization technique, active exercise program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Indianapolis
Blood Loss
Salient Aquamantys Spine Trial
The purpose of this study is to compare standard of care hemostasis techniques with and without the use of Aquamantys in reducing peri-operative blood loss.
- Trial name
- NCT01331499
- Testing
- Bipolar Sealer (Aquamantys), Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Salient Surgical Technologies
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Osteoporosis, Spinal Fusion
Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) in Patients With Osteoporosis After Lumbar Fusion
rhBMP-2 has been used to promote spinal fusion. Despite potential risk of complications, satisfied results could be obtained with low dose of rhBMP-2.
- Trial name
- NCT05911477
- Testing
- RhBMP-2
- Volunteers
- 76 people
- Sponsor
- Xijing Hospital
Degenerative Disc Disease (DDD)
Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease
This study will look at the result of using the FLD device as an artificial lumbar disc. The study will compare the safety and effectiveness of the FLD artificial lumbar disc to an already approved artificial lumbar disc.
- Trial name
- FLD (NCT00775801)
- Testing
- FLD, Control
- Where
- 14 sites in United States, Germany
- Volunteers
- 300 people
- Sponsor
- AxioMed Spine Corporation
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