Clinical trials: Spinal
Amyotrophic Lateral Sclerosis
Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)
The purpose of this research study is to evaluate the safety and effectiveness of CK-2017357 when taken with or without riluzole (also called Rilutek®) in patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT01709149
- Testing
- CK-2017357, Riluzole
- Where
- 75 sites in United States, Canada and 6 more
- Volunteers
- 711 people
- Sponsor
- Cytokinetics
Spinal Cord Injuries
Heated Vest for Persons With Spinal Cord Injury
Persons with higher levels of spinal cord injury (above the 2nd thoracic vertebrae; tetraplegia) are unable to maintain normal core body temperature (Tcore) when exposed to cool environments.
- Trial name
- NCT03662308
- Testing
- Heated Vest, Non-Heated Vest
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cesarean Section Complications
Effect of Preoperative Oral Energy Drinks Compared to Warming Matress on Body Temperature During Combined Spinal-epidural Anesthesia for Elective Cesarean Delivery.
It is not known which is better for intraoperative temperature protection, warming matress or preoperative oral functional drinks in elective cesarean section.
- Trial name
- NCT06017076
- Testing
- Oral energy drinks, Warming matress
- Where
- China
- Volunteers
- 302 people
- Sponsor
- Peking University People's Hospital
Hip Fractures
Conventional Spinal Anaesthesia Versus Fractional Spinal Anaesthesia on Hemodynamics
compare the systemic haemodynamic response to fractional spinal anaesthesia versus conventional spinal anaesthesia , in a group of elderly and comorbid patients with hip fracture.
- Trial name
- NCT06583213
- Testing
- Fractional Spinal Anaesthesia., Conventional Spinal Anaesthesia
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Ain Shams University
Inflammatory Response in Total Knee Arthroplasty
Spinal Versus General Anesthesia and Inflammatory Response Measured by Delta Neutrophil Index in Total Knee Arthroplasty: An Observational Study
This study aims to compare the effects of spinal versus general anesthesia on the inflammatory response measured by Delta Neutrophil Index (DNI) in patients undergoing total knee arthroplasty.
- Trial name
- DNA-TKA (NCT07214558)
- Testing
- Routine Clinical Anesthesia Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Low Back Pain
Evaluation of the Effect of Lumbar Belt on Spinal Mobility in Subjects With and Without Low Back Pain
Low back pain (LBP) is a common condition worldwide as the lifetime prevalence is up to 80%. It is defined as pain in the lumbosacral region in which the etiological causes are most often mechanical, and it is therefore defined…
- Trial name
- LombaMob (NCT05600543)
- Testing
- Lumbar belt, Lombaskin lumbar belt and the Lyne Up percko postural T-shirt.
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Thuasne
Pain, Postoperative
The Effect of Bilateral Erector Spina Plane Block on Postoperative Analgesia in Cesarean Section Under SpinalAnaesthesia
Acute pain after cesarean section (SC) can be variable. Untreated pain can affect patients' life quality. Currently regional nerve blocks are frequently used as a part of multimodal analgesia.
- Trial name
- NCT05695625
- Testing
- Spinal anesthesia + bilateral erector spine plane block, Spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ankara University
Complications; Cesarean Section, Anesthesia; Adverse Effect, Spinal and Epidural
Non-invasive Cardiac Output Monitoring in Obstetric Patients
The investigators hypothesize that continuously measuring stroke volume (SV) and cardiac output (CO) will 1) reveal hemodynamic instability in a timely manner and alert the physician promptly, 2) provide information for the…
- Trial name
- NCT01516697
- Testing
- experimental, Control
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Effects of Dexmedetomidine & Magnesium Sulphate on Patients Undergoing DHS
Comparison Between Intrathecal Magnesium Sulphate & Dexmedetomidine in DHS
To compare the efficacy and safety of intrathecal dexmedetomidine and magnesium sulphate as adjuvants to 0.5% hyperbaric bupivacaine in patients undergoing elective DHS fixation, focusing on onset and duration of sensory and…
- Trial name
- NCT07326397
- Testing
- Dexmedetomidine, Magnesium Sulphate
- Volunteers
- 92 people
- Sponsor
- Assiut University
Orthostatic Hypotension, Spinal Cord Injury
Safety and Efficacy of L-NAME and Midodrine to Increase MAP
After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects…
- Trial name
- NCT00835224
- Testing
- L-NAME, Midodrine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Amyotrophic Lateral Sclerosis, Psychological Stress
Psychological Therapy for Patients With ALS
Amyotrophic lateral sclerosis (ALS) is a disease that is inevitably fatal. To be diagnosed with a terminal illness such as ALS deeply affects one's personal existence and goes along with significant changes regarding the…
- Trial name
- NCT03975608
- Testing
- Adaptation of "CALM"
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- University of Leipzig
Scoliosis Idiopathic Adolescent, Scoliosis
Deep Learning for Early Scoliosis Detection Using mmWave Radar Gait Data
Scoliosis is a sideways curvature of the spine that often develops during childhood and adolescence. When detected early, scoliosis can be managed effectively with non-invasive approaches such as bracing and physiotherapy, while…
- Trial name
- ScoliRadar-AI (NCT07593560)
- Testing
- mmWave Radar Gait Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gebze Technical University
Low Back Pain, Spondylolisthesis
Effects of Exercise Intervention in Patients With Spondylolisthesis Related LBP
The first purpose of this study is to define parameters of the trunk neuromuscular functions that are pathologically altered in patients with low back pain due to spondylolytic spondylolisthesis.
- Trial name
- EXER-SPO-TNC (NCT01985776)
- Testing
- Exercise intervention, Exercise and e-stim
- Where
- 4 sites in Slovenia
- Volunteers
- 48 people
- Sponsor
- University of Primorska
Amyotrophic Lateral Sclerosis (ALS)
A Study to Evaluate the Performance of a Diagnostic Test in ALS
Prospective multicenter study of subjects who were recently diagnosed with amyotrophic lateral sclerosis (ALS) or another neurodegenerative disease (including spinal cord diseases, muscle diseases and neurological diseases such…
- Trial name
- NCT02759913
- Testing
- Lumbar puncture
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Iron Horse Diagnostics, Inc.
Leptomeningeal Metastasis, Leptomeningeal Disease
A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide
The FORESEE Study is a multi-center, prospective clinical trial enrolling patients with Breast or Non-Small Cell Lung Cancer (NSCLC) who have suspicious or confirmed Leptomeningeal Metastases (LM).
- Conditions
- Leptomeningeal Metastasis, Leptomeningeal Disease, Leptomeningeal Neoplasms, Breast Cancer
- Trial name
- FORESEE (NCT05414123)
- Testing
- CNSide
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Biocept, Inc.
Intervertebral Disc Degeneration, Stenosis, Spinal
Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure
This study is designed to evaluate the clinical utility of a known intraoperative neuromonitoring modality (SSEP) using saphenous nerve as the site of stimulation to identify changes to the lumbar nerves which may be at risk…
- Conditions
- Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity
- Trial name
- NCT05648474
- Testing
- Somatosensory evoked potential [SSEP] intraoperative monitoring
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alphatec Spine, Inc.
Spinocerebellar Ataxia Type 3, Machado Joseph Disease
Safety and Efficacy of Lithium Carbonate in Patients With Spinocerebellar Ataxia Type 3
Design: Phase II-III, double-blind, parallel, placebo controlled randomized Clinical trial Background: Spinocerebellar ataxia type 3 (SCA-3) is an autosomal dominant adult-onset neurodegenerative disorder for which there is no…
- Trial name
- NCT01096082
- Testing
- Lithium Carbonate
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
HTLV-I Infections, HTLV-II Infections
Evaluation of the MP Diagnostics HTLV Blot 2.4
The purpose of this study is: 1. To assess the validity and reproducibility of the MP Diagnostics HTLV Blot 2.4. 2. To conduct a sensitivity analysis of the HTLV Blot 2.4 using a known positive population.
- Conditions
- HTLV-I Infections, HTLV-II Infections, Human T-lymphotropic Virus 1, Human T-lymphotropic Virus 2
- Trial name
- NCT01467024
- Testing
- CDPHL Algorithm
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- MP Biomedicals, LLC
Back Pain With Radiation
Evaluation of the Percutaneous SCS Trial Using the DSSEP Collision Testing
This study is to objectively evaluate the success of a spinal cord stimulator (SCS) trial using testing (DSSEP) to determine if the paresthesia (tingling sensation) or pain reduction achieved correlates with the degree of…
- Trial name
- NCT02614079
- Testing
- DSSEP
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Toledo Health Science Campus
Pregnancy
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
The purpose of this study is to determine what dose of medication administered through a combined spinal epidural (CSE) provides the optimal pain relief with the minimal amount of side effects.
- Trial name
- NCT02159807
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
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