Clinical trials: Spinal
Respiratory Depression
Respiratory Depression in Women With BMI≥30 Underwent Spinal Anesthesia With Intrathecal Morphine in Elective C-section
The study will examine whether there is a difference in the frequencies of respiratory depression among obese women receiving spinal anesthesia combined with opioids compared to women with normal BMI.
- Trial name
- NCT02819661
- Testing
- SOMNOTOUCH RESP, Caesarean section, Spinal anesthesia with intrathecal morphine
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy Type III
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
The purpose of this study is to identify the maximum tolerated dosage of sodium phenylbutyrate in children with spinal muscular atrophy types II or III; and to determine if the drug has an effect on SMN mRNA and protein levels.
- Trial name
- NPTUNE01 (NCT00439569)
- Testing
- sodium phenylbutyrate
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- Westat
Vision; Disorder, Loss
The Influence of Prone Position for Spinal Surgery on Visual Acuity
This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery.
- Trial name
- NCT03644641
- Testing
- Desflurane Group, Propofol Group
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Hradec Kralove
Healthy
A Study in Healthy Men to Test How Different Doses of BI 474121 Are Taken up and How They Influence the Amount of a Molecular Messenger (cGMP) in the Spinal Fluid
The main objectives of this trial are: To evaluate the effect of BI 474121 on cyclic guanosine monophosphate (cGMP) levels in cerebrospinal fluid (CSF) To assess the exposure of BI 474121 in CSF relative to plasma To determine…
- Trial name
- NCT04672954
- Testing
- 2.5 milligram (mg) BI 474121, 10 milligram (mg) BI 474121, 20 milligram (mg) BI 474121
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Adolescent Idiopathic Scoliosis
MRI-Guided Dynamic Support System for Scoliosis Correction
This prospective pilot study evaluates the feasibility and effectiveness of an MRI-guided dynamic support system (MRI-DSS) for rapid, quantitative correction of adolescent idiopathic scoliosis (AIS).
- Trial name
- NCT07246122
- Testing
- MRI-guided Dynamic Support System
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Spinal Stenosis Lumbar
Coflex PS3 Actual Conditions for Use Study
A 2 and 5 year evaluation of clinical outcomes in the treatment of degenerative spinal stenosis with concomitant low back pain by decompression with additional stabilization using the coflex® Interlaminar Technology for FDA…
- Trial name
- PAS003 (NCT02555280)
- Testing
- coflex® Interlaminar Technology, Decompression
- Where
- 14 sites in United States
- Volunteers
- 40 people
- Sponsor
- Companion Spine, LLC
Lumbar Spinal Stenosis
Balance Amongst Patients With Lumbar Spinal Stenosis
Lumbar spinal stenosis (LSS) is one of the most common degenerative diseases of the spinal column, with symptoms including low back pain which worsens with ambulation, poor balance, decreased activity due to pain, and a marked…
- Trial name
- B-ATLAS (NCT06075862)
- Testing
- Decompressive surgery
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Region Zealand
Spinal Cord Injuries, Heart Diseases
Coronary Heart Disease as Measured by Coronary Calcium Score Among Individuals With Chronic Traumatic Spinal Cord Injury
This study includes male subjects age 45 to 70, who have sustained a traumatic Spinal Cord Injury (SCI) at least 10 years prior. Subjects will be interviewed for demographic data, including heart disease risk factors.
- Trial name
- NCT00628446
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Wake Forest University Health Sciences
Hypotension, Pregnancy Related
Non-invasive Haemodynamic Monitoring to Predict Spinal Hypotension During Caesarian Section
Spinal anaesthesia for elective caesarean section is associated with maternal hypotension, secondary to alteration of sympathetic tone and hypovolemia, in up to 70% of cases.
- Conditions
- Hypotension, Pregnancy Related, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
- Trial name
- NCT04608227
- Testing
- Clearsight monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospital Nord
Diuresis, Bladder Retention Volume
Effect of Preload on Bladder Retention Volume During Spinal Anesthesia
The purpose of this study is to assess the influence of different fluid infusions on the quantity of bladder retention after spinal anesthesia.
- Conditions
- Diuresis, Bladder Retention Volume, Hypotension
- Trial name
- NCT00550186
- Testing
- Ringers Lactate, HaemoHES 6%
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Rijnstate Hospital
Acute Pain, Surgery
Clinical Study to Evaluate Clinical Impact of PGx-Guided Treatment for Patients Undergoing Elective Spinal Surgical Procedures
The purpose of this study is to evaluate the effect of pharmacogenetic (PGx) guided treatment when implemented into the pre-operative process for patients undergoing an elective spinal surgical procedure and requiring…
- Trial name
- NCT02599870
- Testing
- NeuroIDgenetix Test Panel
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- AltheaDx
Spinal Stenosis
Neurogenic Intermittent Claudication Evaluation Study
The objective of the NICE study is to provide clinical evidence proving that the Aperius™ PercLID™ System is safe and non-inferior to standalone decompressive surgery with regards to clinical outcomes in patients suffering from…
- Trial name
- NICE (NCT00905359)
- Testing
- Aperius™ PercLID™ System, Standalone Decompressive Surgery
- Where
- 19 sites in Australia, Belgium and 8 more
- Volunteers
- 163 people
- Sponsor
- Medtronic Spinal and Biologics
Lumbar Disc Disease, Lumbar Disc Herniation
Physiotherapy in Lumbar Disc Pathologies
The aim of this study is to compare the effectiveness of four physical therapy treatment approaches for lumbar region pathologies. Eighty volunteers who have back pain will be included in the study.
- Conditions
- Lumbar Disc Disease, Lumbar Disc Herniation, Low Back Pain, Mechanical, Low Back Strain
- Trial name
- NCT04061759
- Testing
- Effectiveness of four physical therapy approaches (soft tissue manual therapy, Kinesio® Taping techniques, stabilization exercises and reflex therapy) for treating lumbar disc pathologies.
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Guven Health Group
Spondyloarthropathies, Ankylosing Spondylitis
Faecal Analyses in Spondyloarthritis Therapy
This study evaluates the intestinal microbiome and disease activity in patients with spondyloarthropathies receiving immunosuppressive therapy.
- Trial name
- FAST (NCT03839862)
- Testing
- TNF-inhibition
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Scoliosis
The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery
The primary objective of this study is to determine whether magnesium sulfate has a clinically important effect on the amplitude and latency of somatosensory and motor evoked potentials in patients undergoing surgical correction…
- Trial name
- NCT01148888
- Testing
- Magnesium
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
Cervical Disc Herniation, Lumbar Disc Herniation
The Value of Short-term Pain Relief for the Prediction of Long-term Outcome After Cervical or Lumbar Nerve Root Infiltration
The purpose if this study is to assess the response to nerve root infiltration therapy in patients with cervical or lumbar disc herniations.
- Trial name
- InfStu (NCT01945554)
- Testing
- Cervical nerve root infiltration, Lumbar nerve root infiltration, Mephamesone
- Where
- 3 sites in Switzerland
- Volunteers
- 250 people
- Sponsor
- Holger Joswig
Spinal Cord Injuries
Combination Therapy to Improve SCI Recovery.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.
- Trial name
- BO2ST (NCT05563103)
- Testing
- Daily acute intermittent hypoxia, Walking + tSTIM
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spondylodiscitis
Cytokine Profiles and suPAR in Spondylodiscitis
Spondylodiscitis is an infectious disease of the intervertebral discs and adjacent vertebral bodies, which often has a protracted progression.
- Trial name
- NCT02554227
- Testing
- Cytokine Profile and suPAR
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Cologne
Spinal Cord Injuries, Multiple Sclerosis
Functional and Physiological Responses to Lokomat Therapy (Pilot Study)
Individuals with neurological deficiencies such as those who have spinal cord injury, stroke, traumatic brain injury, Parkinson's disease, and multiple sclerosis often lose their ability to ambulate over ground.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Stroke
- Trial name
- NCT00883142
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- US Department of Veterans Affairs
Undefined
Reducing Pain Intensity During Spinal Needle Insertion: Valsalva Maneuver vs. Control Technique
This study was aimed to observe the efficacy of Valsalva maneuver in reducing pain intensity during spinal needle insertion.
- Trial name
- NCT04029662
- Testing
- Valsalva Maneuver
- Where
- Indonesia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
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