Clinical trials: Spinal Anesthesia for Cesarean Section
Anesthesia, Spinal
Norepinephrine vs. Phenylephrine for Hypotension in Low-Dose Spinal Anesthesia for Cesarean Delivery
This clinical trial was conducted to compare the effectiveness and safety of two medications, norepinephrine and phenylephrine, in preventing hypotension during low-dose spinal anesthesia for cesarean delivery (CD).
- Conditions
- Anesthesia, Spinal, Cesarean Section, Hypotension, Controlled
- Trial name
- NORPHE-CD (NCT07327320)
- Testing
- Norepinephrine, Phenylephrine
- Where
- Vietnam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tam Anh Research Institute
Anesthesia; Adverse Effect, Spinal and Epidural, Hypotension
Colloid Preload Versus Colloid Coload During Cesarean Deliveries
The investigators aimed to compare the methods colloid preloading and colloid coloading in terms of the incidence of maternal hypotension and impacts on neonatal outcomes.
- Trial name
- NCT02393196
- Testing
- hydroxyethyl starch (% 6 HES 130/0.4) (Voluven®), hydroxyethyl starch (%6 HES 130/0.4) (Voluven®)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sifa University
Outcome
Intensive Versus Standard Treatment for Spinal Anesthesia-induced Hypotension on Maternal Hemodynamics
The objective of this study is to investigate the impact of varying maternal blood pressure maintenance targets on maternal hemodynamics following cesarean section.
- Trial name
- NCT06151496
- Testing
- Alpha-Agonist, α-adrenergic receptor agonist
- Volunteers
- 300 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia, Obstetrical, Anesthesia, Spinal
Phenylephrine and Hypotension During Spinal Anesthesia for Cesarean Section
Pregnant women with a positive preoperative Supine stress test were found to be a subgroup at increased risk of symptomatic hypotension after spinal anesthesia
- Trial name
- NCT02958215
- Testing
- Phenylephrine
- Where
- Egypt
- Volunteers
- 980 people
- Sponsor
- Assiut University
Postoperative Pain
Intravenous Ketamine and Postoperative Pain Following Cesarean Section.
The purpose of this study is to investigate the analgesic effect of low-dose intravenous ketamine in pregnant mothers undergoing cesarean section under Bupivacaine spinal anesthesia.
- Trial name
- NCT03018301
- Testing
- Ketamine, Normal saline
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Headache
Postdural Puncture Headache After Spinal Anesthesia for Cesarean Section
Post-dural puncture headache (PDPH) is a potential and debilitating complication of spinal anesthesia in pregnant patients undergoing caesarean sections (CS), with a reported incidence of 0.5%-2% .
- Trial name
- NCT06683807
- Testing
- Hyperbaric bupivacaine 0.5% (2.5 mL) aspirated immediately after opening the bupivacaine ampule, Hyperbaric bupivacaine 0.5% (2.5 mL) aspirated 5 minutes delayed after opening the bupivacaine ampule
- Volunteers
- 55 people
- Sponsor
- Assiut University
Cesarean Section Complications
Intravenous Dexmedetomidine in Cesarean Section Under Spinal Anesthesia
The present study hypothesized that intravenous dexmedetomidine use during spinal anesthesia for cesarean section has a beneficial influence on hemodynamic stability and epigastric pain together with satisfactory analgesic…
- Trial name
- NCT04358367
- Testing
- Dexmedetomidine Injectable Product, Saline
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Egyptian Biomedical Research Network
Hypotension Symptomatic, Obstetric Anesthesia Problems
Prevention of Hypotension During Cesarean Section
The aim of this double-blind randomized study will be to compare a fixed-rate prophylactic noradrenaline infusion to a fixed-rate prophylactic phenylephrine infusion during elective cesarean section under combined spinal-epidural…
- Conditions
- Hypotension Symptomatic, Obstetric Anesthesia Problems, Cesarean Section Complications, Vasoconstriction
- Trial name
- NOR-PHEN (NCT03842046)
- Testing
- phenylephrine infusion, norepinephrine infusion
- Where
- 2 sites in Greece
- Volunteers
- 82 people
- Sponsor
- Aretaieion University Hospital
Pregnancy, Cesarean Section
The Effect of Low-dose Atropine on Sympathetic Blockade in Spinal Cesarean Section Patients
The most common side effect in cesarean section surgeries performed under spinal anesthesia is hypotension, which is seen in over 80% and can cause significant morbidity for the mother and fetus.
- Conditions
- Pregnancy, Cesarean Section, Anesthesia, Spinal
- Trial name
- NCT05892913
- Testing
- Slow dose preemptive Atropine, Ephedrine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abant Izzet Baysal University
Pregnancy, Cesarean Delivery
Crystalloid Versus Colloid Rapid Co-load for Cesarean Delivery Under Spinal Anesthesia
The study aims to compare crystalloid co-loading and colloid co-loading in parturients receiving prophylactic phenylephrine infusion during cesarean delivery in terms of the incidence of hypotension.
- Conditions
- Pregnancy, Cesarean Delivery, Hypotension
- Trial name
- NCT03729076
- Testing
- Crystalloid, Colloid
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Cesarean Section
Fluid Management for Cesarean Section II
Fluid management plays an essential role in cesarean section. In previous study (NCT00488111) the investigators found that prior-epidural anesthesia fluid management produced a more significant role in stabilizing the blood…
- Trial name
- FMCS-II (NCT00973791)
- Testing
- Ringer's Lactate, Six percent hydroxyethyl starch
- Where
- China
- Volunteers
- 860 people
- Sponsor
- Nanjing Medical University
Hypotension
Norepinephrine and Phenylephrine for Maternal Cardiac Output During Spinal Anesthesia for Elective Cesarean Delivery
The purpose of this study is to compare norepinephrine and phenylephrine on the effects of maintaining the cardiac output in Cesarean section under spinal anesthesia.
- Trial name
- NCT02969239
- Testing
- Norepinephrine, Phenylephrine
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Jeju National University Hospital
Post Operative Pain, Cesarean Section Complications
Postoperative Analgesic Efficacy of Trans Abdominis Plane Block
Transverse abdominis plane (TAP) block is an effective method to manage postoperative pain in patients with midline abdominal wall incisions.
- Trial name
- NCT05831501
- Testing
- Trans abdominis plane block
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Hospital, Pakistan
Preoperative Anxiety, Cesarean Delivery
Video Versus Verbal Preoperative Education in Elective Cesarean Delivery
This prospective randomized controlled trial aims to evaluate the effects of verbal and video-based preoperative education on anxiety levels and serum cortisol response in women scheduled for elective cesarean delivery under…
- Conditions
- Preoperative Anxiety, Cesarean Delivery, Stress Response
- Trial name
- VIDEO-CS (NCT07647601)
- Testing
- Video-Based Preoperative Education, Verbal Preoperative Education
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
Postoperative Nausea and Vomiting
Effect of Propofol on Postoperative Nausea and Vomiting.
As PONV is an unpleasant experience that badly affects the patients' quality of life after surgery and the anti-emetic effects of propofol have been seldomly studied in Pakistan, this study aims at investigation of the beneficial…
- Trial name
- (PONV) (NCT05071794)
- Testing
- Propofol, saline 0.9%
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Hemodynamics
Non-invasive vs Invasive Cardiac Output Monitoring During Cesarean Section
This study aims to evaluate the consistency of hemodynamic monitoring between NICAP and NICCO technologies (T20A; Chongqing, China) and the traditional pulse wave analysis method (EV1000; USA).
- Trial name
- NCT06473818
- Testing
- Non-invasive monitoring, Invasive monitoring
- Where
- China
- Volunteers
- 45 people
- Sponsor
- General Hospital of Ningxia Medical University
Adverse Effect
Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine
The purpose of this study is to investigate the effect of different 6% hydroxyethyl starch (130/0.4) coload volumes on the 90% effective dose of norepinephrine infusion prophylaxis for hypotension during spinal anesthesia for…
- Trial name
- NCT05712018
- Testing
- Hydroxyethyl starch coload - 0 ml/kg, Hydroxyethyl starch coload - 5 ml/kg, Hydroxyethyl starch coload - 10 ml/kg
- Where
- China
- Volunteers
- 90 people
- Sponsor
- General Hospital of Ningxia Medical University
Hypotension, Pregnancy
ET50 With Fentanyl for Post Caesarean Section Spinal Hypotension
Hypotension is extremely common after induction of spinal anesthesia for cesarean delivery. Anesthetic blockade of the sympathetic outflow of the spinal cord causes vasodilation, and is one cause of this hypotension.
- Trial name
- ET-50-Fent (NCT01896960)
- Testing
- Bupivacaine with 15 micrograms of fentanyl
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Patient Compliance
Propofol Spinal Procedural Sedation for Cesarean Section
Patient's safety and satisfaction are major concerns of anesthesiologists and obstetricians. According to evidence, guidelines and quality markers, regional anesthesia is preferred over general anesthesia in obstetric surgery.
- Trial name
- NCT03437980
- Testing
- propofol
- Where
- 3 sites in Egypt
- Volunteers
- 228 people
- Sponsor
- Mansoura University
Cesarean Section, Cardiac Output
Best Regimen for Phenylephrine Administration During Cesarean Section
During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low blood pressure is the most common side effect of the spinal medication used to anesthetize the patient prior to the start of surgery.
- Conditions
- Cesarean Section, Cardiac Output, Hypotension
- Trial name
- NCT00996190
- Testing
- Phenylephrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital