Clinical trials: Spinal Bone Metastases
Spinal Metastases, Spinal Tumor
En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor.
The purpose of this clinical trial is to explore the impact of En bloc surgery and separation surgery combined with radiation therapy on the prognosis and survival of patients with spinal oligometastatic cancer, describe the…
- Conditions
- Spinal Metastases, Spinal Tumor, Radiotherapy, Malignant Bone Tumor
- Trial name
- NCT06120426
- Testing
- total en bloc spondylectomy
- Where
- China
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Secondary Osteoporosis, Spinal Cord Injury
The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury
The purpose of this study is to determine the usefulness of a drug, denosumab, to prevent the loss of bone in participants legs due to SCI.
- Trial name
- NCT03029442
- Testing
- Denosumab (Prolia)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Degenerative Disc Disease
Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease
This study is looking at a new machine called the Accu-Spina which administers internal disc decompression by following a computer program.
- Trial name
- NCT00165893
- Testing
- Accu-Spina Device/IDD therapy, Physical Therapy
- Volunteers
- 50 people
- Sponsor
- Emory University
Ankylosing Spondylitis, Axial Spondyloarthritis
Terbinafine Treatment of Axial Spondyloarthropathy
This is a pilot study to determine if further research is warranted to assess if anti-fungal therapy is an effective adjunctive treatment for axial spondyloarthropathy
- Conditions
- Ankylosing Spondylitis, Axial Spondyloarthritis, Psoriatic Spondylitis, Spondylitis Secondary to Inflammatory Bowel Disease
- Trial name
- FUN (NCT05119712)
- Testing
- Terbinafine Tablets, Laboratory Testing
- Where
- United States
- Sponsor
- Oregon Health and Science University
Spinal Metastases, Spinal Tumors
SBRT Technique Implementation for Spinal Metastases Irradiation
Stereotactic body radiotherapy (SBRT) is a highly precise, image-guided radiotherapy technique delivering 1-5 high-dose fractions to spinal metastases.
- Conditions
- Spinal Metastases, Spinal Tumors, Bone Metastases
- Trial name
- NCT07429422
- Testing
- Stereotactic Body Radiotherapy (SBRT) for Spinal Metastases
- Where
- 2 sites in Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
Hemangioma, Neoplasm Metastasis
Direct Injection of Alcohol for the Treatment of Spinal Tumors
Tumors of the spine can be described as primary, meaning that the tumor originated from cells normally found in the spine, or metastatic, cells from another area of the body that have spread to the spine.
- Conditions
- Hemangioma, Neoplasm Metastasis, Spinal Neoplasm
- Trial name
- NCT00001417
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Long-term Outcomes of Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation or Spinal Stenosis
The rate of success 12 months after surgery is reported to be 60-65% in patients with lumbar disc herniation and 60-70% in patients with spinal stenosis.
- Trial name
- NCT02836730
- Testing
- Low back pain surgery
- Where
- Denmark
- Volunteers
- 425 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone
Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement
This clinical trial tests how well monitoring the sacral reflexes during surgery (intraoperatively) works to predict the post operative function for patients undergoing removal of the lowest part of the spine (sacrectomy) for…
- Trial name
- NCT07707024
- Testing
- Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- City of Hope Medical Center
Scoliosis
Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
The purpose of this study is to determine whether full-time high dose prophylactic bracing (23 hours or more per day) is more effective than low dose bracing (12 hours or less per day) in preventing or delaying spinal curve…
- Trial name
- NCT00256672
- Testing
- Thoraco-Lumbar-Sacral-Orthoses (TLSO) / Flex-Foam
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Shriners Hospitals for Children
Spinal Bone Metastases, Radiation Therapy
A Single-center Observational Clinical Trial of Stereotactic Radiotherapy on Metastatic Spinal Tumors Using TomoTherapy
A single-center observational clinical trial will be performed for metastatic spinal tumors by stereotactic radiotherapy using TomoTherapy.
- Trial name
- SM-SBRT (NCT05808998)
- Testing
- Stereotactic body radiotherapy
- Volunteers
- 45 people
- Sponsor
- Shanghai Zhongshan Hospital
Spinal Fracture, Osteoporosis
Quality of Life After Vertebroplasty Versus Conservative Treatment in Patients With Painful Osteoporotic Vertebral Fractures
The purpose of this study is to determine whether percutaneous vertebroplasty is able to improve long-term quality of life in patients with pain secondary to osteoporotic vertebral fractures, compared to conventional medical…
- Conditions
- Spinal Fracture, Osteoporosis, Back Pain
- Trial name
- NCT00994032
- Testing
- percutaneous injection of cement into the vertebral body, Medical treatment
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Clinic of Barcelona
Vertebral Bony Metastases
Differentiated Resistance Training of the Paravertebral Muscles in Patients With Unstable Spinal Bone Metastasis Under Concomitant Radiotherapy
Standard indications for palliative radiation of bony metastases include pain, spinal cord compression, and impending pathologic fractures.
- Trial name
- DISPO-2 (NCT02847754)
- Testing
- Isometric resistance training
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Intervertebral Disc Displacement, Intervertebral Disc Degeneration
Safety and Efficacy With NOVOCART® Disc Plus (ADCT) for the Treatment of Degenerative Disc Disease in Lumbar Spine
NOVOCART® Disc plus is being investigated to explore its clinical applicability, safety and efficacy in the repair of a herniated disc with an indication for an elective sequestrectomy, and of the adjacent degenerated disc, if…
- Trial name
- NDisc (NCT01640457)
- Testing
- NOVOCART® Disc plus, NOVOCART® Disc basic
- Where
- 10 sites in Austria, Germany
- Volunteers
- 120 people
- Sponsor
- Tetec AG
Cuff Tear Arthropathy, Primary Osteoarthritis
Follow-up Evaluating Clinical and Radiological Outcomes of Total Shoulder Arthroplasty With Permedica's MIRAI Prosthesis
This observational study is conducted in order to evaluate the effectiveness of the primary total shoulder arthroplasty with the Permedica's MIRAI Modular Shoulder Prosthesis System on the general population of patients who are…
- Conditions
- Cuff Tear Arthropathy, Primary Osteoarthritis, Secondary Osteoarthritis, Shoulder Osteoarthritis
- Trial name
- NCT05128500
- Testing
- Total Shoulder Arthroplasty with Permedica's MIRAI
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 76 people
- Sponsor
- Permedica spa
Spinal Cord Injury (=3 Years), Sublesional Bone Loss Secondary to SCI
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date.
- Trial name
- Chronic Romo (NCT04232657)
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Surgery, Brain Tumor
Neurosurgical Transitional Care Programme
Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery.
- Conditions
- Surgery, Brain Tumor, Brain Tumor, Recurrent, Brain Pathology
- Trial name
- TCP (NCT03593330)
- Testing
- Transitional Care Programme
- Where
- United Kingdom
- Volunteers
- 242 people
- Sponsor
- Barts & The London NHS Trust
Lumbar Spinal Stenosis Secondary to Other Disease
NanOss Bioactive With Autograft and Bone Marrow Aspirate in the Posterolateral Spine
The purpose of this study is to assess lumbar fusion using nanOss Bioactive bone void filler
- Trial name
- NCT02005341
- Testing
- nanOSS, Autograft
- Sponsor
- Pioneer Surgical Technology, Inc.
Spondyloarthritis
Comparative Analysis of Two Therapeutic Strategies in Patients With Spondyloarthritis Treated With Anti-tnf Biologics
The objective of the study is to evaluate two therapeutic strategies: "early switch" or "therapeutic intensification" in patients with spondyloarthritis in case of secondary treatment failure suspicion to a first monoclonal…
- Trial name
- STRADA (NCT01971918)
- Testing
- anti drug antibodies dosage
- Where
- 7 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Rouen
Bone Metastases in Subjects With Advanced Cancer
Research on the Optimization of Treatment for Spinal Metastases With Radioactive Particle Implantation Using TPS and Mechanical Dual Simulation
This prospective, open-label randomized trial evaluates a dual-simulation planning strategy that combines standard brachytherapy TPS with patient-specific biomechanical modeling for radioactive seed implantation in bone…
- Trial name
- NCT07171996
- Testing
- Dual-Simulation TPS + Biomechanical Planning, Conventional TPS Planning
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Li Min
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley