Clinical trials: Spinal Bone Metastases
Cancer, Hematologic Malignancies
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.
- Conditions
- Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology
- Trial name
- NCT01345019
- Testing
- Denosumab, Zoledronic acid, Denosumab (for the open-label treatment phase)
- Where
- 309 sites in United States, Australia and 27 more
- Volunteers
- 1,718 people
- Sponsor
- Amgen
Cancer, Spinal Disease
Anderson Circulating Tumor Cell Burden (CTCB) Study
Phase 1 - Optimization Phase: Primary Objective: The primary objective of Phase 1 of this study is to determine the time point at which maximal Circulating Tumor Cell Burden (CTCB) occurs following standard vertebroplasty and…
- Conditions
- Cancer, Spinal Disease, Vertebral Compression Fractures
- Trial name
- NCT00819832
- Testing
- Kyphoplasty, Vertebroplasty, Cavity SpineWand
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Cancers, Multiple Myeloma
Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer
Vertebral augmentation with radiotherapy to increase the functional status and quality of life for patients with vertebral body metastatic cancers.
- Conditions
- Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
- Trial name
- NCT02376933
- Testing
- Vertebroplasty, Radiotherapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Arizona
Non-Small-Cell Lung Carcinoma, Liver Cancer
Stereotactic Body Radiation Therapy (SBRT) in Metastatic Non-small Cell Lung Cancer
This protocol is a single arm phase II multi-center trial evaluating the efficacy of Stereotactic Body Radiation Therapy (SBRT) in patients with oligometastatic non-small cell lung cancer (NSCLC) with response or stable disease…
- Conditions
- Non-Small-Cell Lung Carcinoma, Liver Cancer, Adrenal Cancer
- Trial name
- NCT01185639
- Testing
- stereotactic body radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Wake Forest University Health Sciences
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder
Lumbar Herniated Disc
Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy
To compare the outcomes of percutaneous lumbar Hydrodiscectomy (HydroD) with the SpineJet Hydrodiscectomy System to transforaminal epidural steroid injections (TESI) in patients with lumbar radiculopathy due to contained disc…
- Trial name
- NCT02414698
- Testing
- Percutaneous Hydrodiscectomy, TESI
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Spinal Neoplasms
Evaluation of Single Session Stereotactic Body Radiotherapy
The goal of this clinical research study is to find out if stereotactic body radiotherapy to the spine using computerized tomography (CT)-on-Rails is safe and effective in the treatment of metastatic spine tumors.
- Trial name
- NCT00492817
- Testing
- Stereotactic Body Radiotherapy
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Cancer, Pain
Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00922974
- Testing
- External beam radiation therapy, Radiosurgery/SBRT
- Where
- 38 sites in United States, Canada and 1 more
- Volunteers
- 399 people
- Sponsor
- Radiation Therapy Oncology Group