Clinical trials: Spinal Cord Injuries (SCI)
Spinal Cord Injuries, Spinal Cord Diseases
Targeted HD-tDCS to Improve Upper Limb Rehabilitation in SCI
The proposed project seeks to maximize the functional recovery achieved during the rehabilitation of the paretic upper limbs in individuals with SCI.
- Trial name
- NCT05589415
- Testing
- High-definition Transcranial Direct Current Stimulation, Conventional Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas Rio Grande Valley
SCI - Spinal Cord Injury, PD - Parkinson's Disease
Differential Assessment of Hypertonia
Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements.
- Trial name
- NCT06596187
- Testing
- Continuous passive motion device (CPM) of ankle - fast, Continuous passive motion device (CPM) of ankle - slow
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Spinal Cord Injuries
Training for Persons With Complete SCI for FES Cycling: a Case Series
The main objective of this study is to validate the effectivity of a simple home-based training for cycling with functional electrical stimulation (FES).
- Trial name
- NCT04412447
- Testing
- Functional Electrical Stimulation
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Centre de Rééducation et Réadaptation Fonctionnelle La Châtaigneraie
Spinal Cord Injury
FES Rowing for Skeletal Health After SCI
Following a complete spinal cord injury (SCI), individuals experience progressive bone loss, especially in the legs, with up to 70% of persons with SCI sustaining a fracture at some point during their lifetime.
- Trial name
- FES-R (NCT02008149)
- Testing
- Rowing exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
SCI - Spinal Cord Injury
Food Intake and Thermogenesis in High Spinal Cord Injury
The purpose of this research is to determine the effects of food on cardiovascular and metabolic health in men with and without spinal cord injury (SCI).
- Trial name
- NCT07103993
- Testing
- Low meal condition, Moderate meal condition, High meal condition
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Miami
Spinal Cord Injury, Spinal Cord Injury Cervical
Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury
Stimulation of the spinal cord and brain represents a new experimental therapy that may have potential to restore movement after spinal cord injury.
- Trial name
- NCT06867809
- Testing
- Epidural spinal cord stimulation and paired spine and brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Jason Carmel
Spinal Cord Injury (SCI), Respiratory Complication
Effect of Resistive Inspiratory Muscle Training Optimizing Lung Function in Spinal Cord Injury
The goal of this clinical trial is to evaluate the effectiveness of resistive inspiratory muscle training (RIMT) in optimizing lung function in individuals with spinal cord injury (SCI).
- Trial name
- NCT06547606
- Testing
- Usual Care
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dhaka
Spinal Cord Injury
Indego Exoskeleton After SCI
The purpose of this study is to assess the use of Indego as a gait training tool for subjects with complete or incomplete paraplegia as a result of spinal cord injury (SCI) who have preserved lower extremity function.
- Trial name
- NCT02793635
- Testing
- Indego Powered Exoskeleton
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Parker Hannifin Corporation
Spinal Cord Injuries
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury (BoxSwitch)
The purpose of this pre-market clinical study is to assess the preliminary safety and efficacy of the ARC Therapy using the ARC-IM Lumbar System at supporting mobility in participants who have previously received a spinal array…
- Trial name
- BoxSwitch (NCT05942339)
- Testing
- Procedure/Surgery
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injuries
TCES for Upper Limb Function in Cervical SCI
Following a cervical spinal cord injury (cSCI; damage to the spinal cord at the neck) there is catastrophic loss of hand and grip function. This has a devastating effect on quality of life and functional independence.
- Trial name
- NCT05801536
- Testing
- SCONE
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Leeds
Spinal Cord Injuries
Safety of Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal Injection for SCI
This trial will study the safety and efficacy of intrathecal injection of cultured allogeneic adult umbilical-cord or placental derived mesenchymal stem cells for the treatment of spinal cord injury
- Trial name
- NCT05018793
- Testing
- Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal injection
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Cervical Spinal Cord Injury, Tetraplegia
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
- Trial name
- NCT06288763
- Where
- 10 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries, Chronic Pain
SCI Pain App Intervention Study
The purpose of this study is to find out if using an app is a feasible and acceptable treatment for chronic pain in persons with spinal cord injury.
- Trial name
- NCT04818814
- Testing
- Mindfulness Meditation App, Engagement and Distraction App
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Gait Impairment, Cerebral Palsy (CP)
Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting
The primary objective of the study is to validate the safety and clinical performance of the ABLE Kids device in pediatric patients with neurological gait disorders or muscular weakness during a 10-session gait training program…
- Conditions
- Gait Impairment, Cerebral Palsy (CP), Neuromuscular Diseases (NMD), Spinal Cord Injuries (SCI)
- Trial name
- NCT07745712
- Testing
- ABLE Kids
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- ABLE Human Motion S.L.
Spinal Cord Injuries
Longitudinal Assessment of Spinal Cord Structural Plasticity Using DTI in SCI Patients
This study will apply novel magnetic resonance imaging (MRI) techniques to investigation of spinal cord injury (SCI) to learn how nerve fibers repair and neural cells regain ability to control muscle during the rehabilitation.
- Trial name
- NCT03069222
- Testing
- Standard Rehabilitative Treatment
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Spinal Cord Diseases
SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training
This is a single blind, sham controlled crossover trial that will evaluate the effectiveness of acute intermittent hypoxia therapy (AIH) combined with transcutaneous (non-invasive) spinal cord stimulation on gait and balance…
- Trial name
- NCT03922802
- Testing
- Acute Intermittent Hypoxia + Non Invasive Spinal Cord Stimulation + Gait Training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
SCI-Lynx: A Mobile Platform for Physical Activity Social Support for People With SCI Pilot Study
Physical activity is important to maintain health, fitness, and function in people with spinal cord injury (SCI) and social support is one of the most effective ways to increase physical activity participation.
- Trial name
- NCT05764135
- Testing
- SCI-Lynx Mobile Application
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Brigham and Women's Hospital
Spinal Cord Injuries
Efficacy of a Wearable Noninvasive Neuromodulation Device
The aim of this study is to investigate the potential of transcutaneous neuromodulation (TNM) to treat slow colonic transit and constipation, termed the Neurogenic bowel dysfunction (NBD), in people with SCI.
- Trial name
- NCT07171489
- Testing
- TNM at a leg point (AccelBand)- randomized arm, TNM at a leg point (AccelBand)- open-label
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Spinal Cord Injuries and Disorders (SCI/D)
Using Non-invasive Brain and Spinal Cord Stimulation to Improve Arm and Hand Function After Spinal Cord Injury
Cervical spinal cord injury (SCI) disrupts communication between the brain and spinal circuits, affecting voluntary movement control and contributing to arm and hand impairments, the top recovery priority for people with…
- Trial name
- NCT07423949
- Testing
- Cerebellar theta burst stimulation, Cervical transcutaneous spinal cord stimulation, Functional task practice
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development