Clinical trials: Spinal Cord Injury(SCI)
Lower Urinary Tract Symptoms
Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB
As a collaborative effort between MedStar National Rehabilitation Hospital (NRH)/MedStar Health Research Institute (MHRI), Children's National Medical Center (CNMC) Department of Urology, Children's Research Institute (CRI)…
- Trial name
- NCT02748317
- Testing
- Lactobacillus rhamnosus GG
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Medstar Health Research Institute
Trauma, Spinal Cord, SPINAL Fracture
A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury.
The study is designed to investigate whether autonomic shifts (dysautonomia, sympatho-vagal instability) that develop after SCI have value in predicting SCI-associated infections (SCI-AI).
- Trial name
- NCT03253952
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Incomplete Spinal Cord Injury (SCI)
Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.
The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury.
- Trial name
- tSCS_SJD_PMI_1 (NCT07445685)
- Testing
- Transcutaneous spinal cord stimulation on the dorsal region between T11 and T12
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Sant Joan de Déu
Central Neuropathic Pain, Spinal Cord Injury
Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury
The goal of this pilot clinical trial is to find out how well low dose naltrexone works for people with pain due to spinal cord injury.
- Trial name
- NCT06723561
- Testing
- 4.5mg daily dose of naltrexone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical College of Wisconsin
Spinal Cord Injuries (SCI)
tESCS for Upper Limb Rehab in Spinal Cord Injury
Regaining hand and arm function is an important step towards regaining independence following high-level spinal cord injury (tetraplegia).
- Trial name
- SCIRUS (NCT07208188)
- Testing
- Transcutaneous spinal cord stimulation (tESCS) active group
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injuries, Spinal Injuries
DBS of PPN to Improve Walking in Chronic SCI Patients
Spinal cord injury (SCI) is a devastating condition affecting over 1 million individuals in North America. SCI often results in severe motor impairments with few available treatments options.
- Conditions
- Spinal Cord Injuries, Spinal Injuries, Spinal Fractures
- Trial name
- NCT04325165
- Testing
- DBS Implantation
- Sponsor
- University Health Network, Toronto
Spinal Cord Injury
Measurement of Autonomic Cardiovascular Integrity in Persons With SCI
People with a spinal cord injury (SCI) have limited ability to move and feel sensation below the level of the SCI. Doctors and researchers have tests which determine the level of function and sensation, this test was developed by…
- Trial name
- NCT01758692
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury
Home/Work, Community Mobility Skills in the ReWalk Exoskeleton in Persons With SCI
The overall goal of this project is to determine if non-ambulatory persons with spinal cord injury (SCI) who have already participated in at least 20 sessions of ReWalk training can be further trained to achieve more advanced…
- Trial name
- VA_ReWalk2 (NCT02118194)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Functional Electrical Stimulation During Cycling in People With Spinal Cord Injury
Neuroscience research that has identified potential for recovery (neuroplasticity) following incomplete SCI has changed clinical practice away from compensation strategies towards optimizing recovery.
- Trial name
- iCycle (NCT03834324)
- Testing
- FES
- Volunteers
- 11 people
- Sponsor
- University of Southampton
Spinal Cord Injury
The Effect of Neck Stabilization Exercise Plus Cardiopulmonary Rehabilitation on Pulmonary Function of SCI
Cervicocranial flexion exercise (CCFE) and superficial neck flexor endurance training have been widely implemented in clinical practice for curing chronic neck pain.
- Trial name
- NCT04500223
- Testing
- Cervical Cranioflexion exercise plus cardiopulmonary exercise, Cervical stretch exercise plus cardiopulmonary rehabilitation
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- Taoyuan General Hospital
Chronic Spinal Cord Injury
Impact of Persistent Conductances on Motor Unit Firing in SCI
This study is being done to measure the differences between the electrical activity of muscles and /single muscle fibers in individuals with long-term spinal cord injury and neurologically intact individuals without spinal cord…
- Trial name
- NCT02136823
- Testing
- sugar pill, Riluzole, Isradipine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries, Cognitive Decline
SCED Myokines and Cognition in SCI
Rationale: Individuals with spinal cord injury (SCI) suffer from accelerated cognitive aging. In able-bodied individuals, a vast amount of studies have shown that exercise interventions can improve cognitive function.
- Trial name
- NCT05822297
- Testing
- Neuromuscular electrical stimulation
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Adelante, Centre of Expertise in Rehabilitation and Audiology
Spinal Cord Injury (SCI), Chronic Urinary Retention
Tissue Bonding Cystostomy(TBC)
Spinal Cord Injured [SCI] patients typically cannot "pee". Injury to the spinal cord disrupts the in-coming and out-going brain signals that coordinate bladder sensation and the emptying of bladder.
- Conditions
- Spinal Cord Injury (SCI), Chronic Urinary Retention, Urinary Incontinence
- Trial name
- TBC (NCT01771159)
- Testing
- TBC
- Volunteers
- 10 people
- Sponsor
- Uro-Research, LLC
Spinal Cord Injuries (SCI)
RTsMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury
The aim of this study is to assess the feasibility of combining rTsMS with BWSTT for gait and sensorimotor recovery in individuals with incomplete spinal cord injury.
- Trial name
- NCT06886308
- Testing
- Repetitive trans-spinal magnetic stimulation
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Universidade Federal de Pernambuco
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Vibration for Muscle Spasms After Spinal Cord Injury
This study uses closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms responsible for spasm generation change in…
- Trial name
- NCT03598504
- Testing
- Wearable EMG/Vibration device
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Sleep Apnea, SCI/D
Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury
It is estimated that 1,275,000 people in the United States alone live with spinal cord injury, including around 100,000 Veterans with spinal cord injury, making the V.A.
- Conditions
- Sleep Apnea, SCI/D, Hypercapnia
- Trial name
- RECOV2SCI (NCT05536076)
- Testing
- Hypercapnia treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Using Muscle Functional MRI to Study Spatial Muscle Activation Patterns in People With SCI
Several types of treatment and therapy have been shown to promote improvements in movement and other health gains in people with spinal cord injury (SCI).
- Trial name
- NCT07073313
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Spinal Cord Injury
24hr Effects of Tiotropium Bromide in Tetraplegia
Respiratory complications are the leading cause of death during the initial year after acute SCI, and the third leading cause of death thereafter.
- Trial name
- NCT02586649
- Testing
- Tiotropium Bromide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center