Clinical trials: Spinal Cord Injury(SCI)
Spinal Cord Injury Cervical, Neuropathic Pain
PAS for Post-SCI Neuropathic Pain
The investigators have shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles.
- Trial name
- NCT05362422
- Testing
- long-term paired associative stimulation
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- Helsinki University Central Hospital
Spinal Cord Injuries
Effect of Vibration Therapy on Bone in Persons With Sub-acute Spinal Cord Injury
The purpose of this research study is to determine the effect of mechanical vibrations on bones of persons with spinal cord injury.
- Trial name
- NCT00886145
- Testing
- Vibration: Right Leg and No Vibration: Left Leg.
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- William A. Bauman, M.D.
Chronic Incomplete Cervical Spinal Cord Injury (SCI)
Safety and Feasibility of Paired Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Upper Limb Rehabilitation in Incomplete Spinal Cord Injury
The purpose of this study is to evaluate the safety and feasibility of transcutaneous auricular Vagus Nerve Stimulation (taVNS) paired with upper-limb rehabilitation in adults with tetraplegia caused by cervical spinal cord…
- Trial name
- NCT06543277
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries, Bowel Dysfunction
Noninvasive Spinal Cord Stimulation for Early SCI
The investigators are looking to determine the safety and efficacy of non-invasive transcutaneous spinal cord stimulation (TSCS) in promoting recovery of lower urinary tract (LUT), bowel, sexual, and cardiovascular function, as…
- Conditions
- Spinal Cord Injuries, Bowel Dysfunction, Sexual Dysfunction, Autonomic Dysfunction
- Trial name
- NCT06587841
- Testing
- Spinal COrd NEuromodulation™ (SCONE™) for transcutaneous spinal cord stimulation (TSCS)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries
Brain Monitoring, tDCS and Robotic Training in SCI
To explore the neurophysiological and electroencephalography (EEG) changes that one single session of tDCS and robotics has in the SCI population (Study 1); and to investigate upper limb motor recovery in chronic tetraplegia SCI…
- Trial name
- NCT06813287
- Testing
- Electroencephalography (EEG), Upper extremity robot
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Kathleen Friel
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Tetraplegia/Tetraparesis, Quadriplegia
Precise Robotically IMplanted Brain-Computer InterfacE
The PRIME Study is a first-in-human early feasibility study to evaluate the initial clinical safety and device functionality of the Neuralink N1 Implant and R1 Robot device designs in participants with tetraparesis or…
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- PRIME (NCT06429735)
- Testing
- N1 Implant, R1 Robot
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Neuralink Corp
Spinal Cord Injuries (SCI), Neurogenic Bladder
Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation
The goal of this clinical trial is to determine whether Lactobacillus crispatus strains isolated from the lower urinary tracts of adult women can be used as an antibiotic-sparing treatment for urinary symptoms and urinary tract…
- Conditions
- Spinal Cord Injuries (SCI), Neurogenic Bladder, Urinary Tract Infection (Diagnosis)
- Trial name
- NCT07308808
- Testing
- Lactobacillus Crispatus, Saline bladder wash
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medstar Health Research Institute
Spinal Cord Injury
Training of Eccentric Lower Extremity Function After SCI
This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill training at moderate speeds …
- Trial name
- NCT02498548
- Testing
- Trained SCI Knee or Trained SCI Hip
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Spinal Cord Injuries
LTFU Study of Subjects With Cervical SCI Who Received AST-OPC1
This is a LTFU study for cervical SCI subjects that were administered AST-OPC1 cells in the main study AST-OPC1-01.
- Trial name
- NCT05975424
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Lineage Cell Therapeutics, Inc.
Spinal Cord Injury
Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury.
- Trial name
- NCT01272349
- Testing
- Acute intermittent hypoxia, Room air
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Emory University
Spinal Cord Injuries
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury (BoxSwitch)
The purpose of this pre-market clinical study is to assess the preliminary safety and efficacy of the ARC Therapy using the ARC-IM Lumbar System at supporting mobility in participants who have previously received a spinal array…
- Trial name
- BoxSwitch (NCT05942339)
- Testing
- Procedure/Surgery
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injury
AIH-induced Walking Recovery After Subacute SCI
The purpose of this study is to determine how mild breathing bouts of low oxygen may restore walking and leg strength in persons who have sustained a spinal cord injury.
- Trial name
- NCT02632422
- Testing
- Daily acute intermittent hypoxia (dAIH), Walking
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury, Stroke
Medical Device for Magnetic Therapy for Spinal Cord Injuries (SCI)
A medical device for magnetic therapy for spinal cord injuries (SCI) will be disclosed. The apparatus comprises a combination of several magnets enclosed in a supportive cover.
- Trial name
- SCIMAG (NCT02333695)
- Testing
- Spinal Magnetic Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- American Society Of Thermalism And Climatology Inc
Spinal Cord Injuries
Spinal Neurorehabilitation for Veterans With SCI
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure.
- Trial name
- NCT07222046
- Testing
- Neurophysiological and anatomical testing, Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Neuropathic Pain, Spinal Cord Injuries (SCI)
High-frequency Alternating Current Stimulation for Neurophatic Pain in Spinal Cord Injury
To investigate the safety and effectiveness of transcutaneous electrical stimulation with 40 kHz alternating currents combined with standard treatment compared to placebo electrical stimulation plus standard treatment for…
- Trial name
- NCT07359677
- Testing
- Active group 40 kHz
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Castilla-La Mancha
Spinal Cord Injury (SCI)
Safety and Usability of the ATLAS 2030 Exoskeleton in Pediatric Patients With Spinal Cord Injury
The goal of this clinical trial is to analyze the usability and safety of the robotic gait ATLAS 2030 in a cohort of pediatric patients with Spinal Cord Injury, with the aim of extending its indication for use to pediatric spinal…
- Trial name
- NCT06772077
- Testing
- Rehabilitation treatment with ATLAS2030
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- MarsiBionics
Spinal Cord Injuries (SCI)
Myofascial Release and 20-m Speed in Wheelchair Rugby Athletes With Spinal Cord Injury
This study aims to investigate the effect of myofascial release on sprint performance in wheelchair rugby athletes with spinal cord injury.
- Trial name
- MFR20MWR (NCT07711015)
- Testing
- Myofascial Release
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Centro Universitário Augusto Motta
Sarcopenic Obesity, Spinal Cord Injuries
Sarcopenic Obesity in Neurodisabilities
To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities
- Conditions
- Sarcopenic Obesity, Spinal Cord Injuries, Stroke, Multiple Sclerosis
- Trial name
- SarcObeNDS (NCT03863379)
- Testing
- whole body DXA
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
Spinal Cord Injury, Ambulation Difficulty
Exoskeleton and Spinal Cord Stimulation for SCI
The overall aim of this project is to assess the effect of combining transcutaneous lumbosacral stimulation (TLS) during Exoskeleton Assisted Walking (EAW) compared to EAW alone without stimulation on walking recovery.
- Conditions
- Spinal Cord Injury, Ambulation Difficulty, Muscle Spasticity
- Trial name
- NCT03096197
- Testing
- Exoskeleton-Assisted Walking, Transcutaneous Lumbosacral Stimulation (TLS)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kessler Foundation