Clinical trials: Spinal Cord Injury, Chronic
Bone Loss, Spinal Cord Injuries
Intervention on Bone Health in Wheelchair Users
The low mechanical loading of bones among wheelchair users leads to an increased risk of bone fractures and associated complications due to low bone mineral density (BMD).
- Conditions
- Bone Loss, Spinal Cord Injuries, Cerebral Palsy, Spina Bifida
- Trial name
- BoneWheel (NCT05615402)
- Testing
- Bone-specific strength training, Nutrition optimalisation
- Where
- Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Injury
Comparison of Lokomat and Aquatic Exercise for Individuals With Chronic Incomplete Spinal Cord Injury
Many people with spinal cord injury (SCI) hold some ability to move their leg muscles, and are therefore considered to demonstrate a motor incomplete injury.
- Trial name
- NCT01407354
- Testing
- Lokomat treadmill training, Aquatic exercise therapy
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Maryland, Baltimore
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Spinal Cord Injury
Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition
The study will be conducted in two steps: 1. Determination of the Minimal Effective Dose (MED) among the four doses of the panel 2. Estimation of the probability of response associated to the MED.
- Trial name
- RILUSCI (NCT02859792)
- Testing
- Riluzole, Blood Samples
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Spinal Cord Injury, Paraplegia
The Safety of ahSC in Chronic SCI With Rehabilitation
The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) transplantation in participants with chronic SCI.
- Conditions
- Spinal Cord Injury, Paraplegia, Quadriplegia, Tetraplegia
- Trial name
- NCT02354625
- Testing
- Autologous human Schwann cells
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- W. Dalton Dietrich
Spinal Cord Injuries, Constipation
Trancutaneous Abdominal Stimulation on Bowel Function.
This is a prospective, single-center, feasibility study to determine the sensations elicited by non-invasive abdominal electrical stimulation and its effects on bowel function in spinal cord injured individuals and in able-bodied…
- Trial name
- NCT04627168
- Testing
- Non-invasive, surface electrical stimulation device, DS5 Digitimer
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Amol Soin, M.D., MBA
Spinal Cord Injury
NeuroRegen Scaffold™ With Bone Marrow Mononuclear Cells Transplantation vs. Intradural Decompression and Adhesiolysis in SCI
The purpose of this study is to investigate the efficacy and safety of NeuroRegen Scaffold with bone marrow mononuclear cells (BMMCs) on neurological recovery following chronic and complete spinal cord injury, compared to the…
- Trial name
- NCT02688062
- Testing
- NeuroRegen Scaffold with BMMCs transplantation, Surgical intradural decompression and adhesiolysis
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Chinese Academy of Sciences
Spinal Cord Injuries
Neuro-navigated TMS for Chronic SCI Patients
Can neuro-navigated Transcranial Magnetic Stimulation be used as an additional outcome measure to EM-SCI assessments in a Spinal cord injury trial? Compare EM-SCI assessment with nTMS in ten chronic thoracic SCI patients Compare…
- Trial name
- NCT06075056
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust
Spinal Cord Injuries, Spinal Cord Diseases
Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal
The objectives of this study are to (1) determine the effects of neuromodulation techniques on mobility in persons with chronic SCI, as measured by subjective and objective measures, and (2) to determine the optimal combination…
- Trial name
- RISES-T2 (NCT05994846)
- Testing
- RISES-T System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Spinal Cord Injuries, Tetraplegia
Combined Robotic Training and tDCS in Chronic SCI
The purpose of this study is to establish the value of combined non-invasive stimulation (tDCS) and behavioral training (robotics) in SCI rehabilitation, and understand the mechanisms of this interaction and its relationship to…
- Trial name
- NCT03555838
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Burke Medical Research Institute
Spinal Cord Injuries
Acceptance and Commitment Therapy for Chronic Pain in SCI: Development and Testing of an eHealth Program
This study will test the newly-developed My spinal cord injury (SCI) Toolkit program in two formats - unguided use of the program and use supported by a coach.
- Trial name
- NCT06098170
- Testing
- Unguided use of the My SCI Toolkit program, Coached My SCI Toolkit
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Michigan
Neuromuscular Disorders, Neurodevelopmental Disorders
Efficacy and Usability of the EXPLORER Exoskeleton in Children With Neurodevelopmental Disorders in Natural Environments
Neurodevelopmental disorders often lead to abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as an inability to stand and walk.
- Trial name
- NCT06765070
- Testing
- EXPLORER
- Where
- 6 sites in Spain
- Volunteers
- 15 people
- Sponsor
- MarsiBionics
Spinal Cord Injury
The Effect of rTMS in Patients With Spinal Cord Injury (rTMS:Repetetive Transcranial Magnetic Stimulation)
It is postulated that high frequency repetitive transcranial magnetic stimulation (rTMS) can decrease the corticospinal inhibition and enhance the motor recovery.
- Trial name
- rTMS: (NCT04372134)
- Testing
- repetitive transcranial magnetic stimulation therapy
- Volunteers
- 28 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Spinal Cord Injuries, Hypotension
The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)
This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic…
- Conditions
- Spinal Cord Injuries, Hypotension, Orthostatic Hypotension, Spinal Cord Diseases
- Trial name
- SCI (NCT05725499)
- Testing
- Biostim-5 transcutaneous spinal stimulator, Tilt-table orthostatic stress testing
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation
Neuropathic Pain, Spinal Cord Injury
The Effects of Anodal tsDCS on Chronic Neuropathic Pain After SCI
The purpose of this study is to evaluate the analgesic effect of transcutaneous spinal direct current stimulation (tsDCS) applied on spinal cord in patients with spinal cord injury who have chronic neuropathic pain.
- Trial name
- NCT02863315
- Testing
- tsDCS
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Spinal Cord Injuries, Spinal Cord Diseases
Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury
This study is a single blinded prospective randomized monocentric study examining the effectiveness of transcutaneous auricular vagus nerve stimulation paired with rehabilitation and low frequency/antidromic stimulation of the…
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Nervous System Diseases, Trauma, Nervous System
- Trial name
- taVNS (NCT05852379)
- Testing
- active taVNS
- Volunteers
- 10 people
- Sponsor
- Possover International Medical Center AG
Spinal Cord Injuries
FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI
The main objective of this study is to determine the effectiveness of a new treatment regime that uses electrical stimulation for the improvement of hand function in persons with spinal cord injuries (SCI).
- Trial name
- NCT01208688
- Testing
- FES Therapy, Conventional Occupational Therapy
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Toronto Rehabilitation Institute
Spinal Cord Injury, Chronic Pain
Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury
The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with spinal cord injury. This study is part of the Spaulding-Harvard Model System.
- Conditions
- Spinal Cord Injury, Chronic Pain, Neuropathic Pain
- Trial name
- NCT01599767
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury
NeuroRegen Scaffold™ Combined With Stem Cells for Chronic Spinal Cord Injury Repair
The purpose of this study is to assess the efficacy and safety of mesenchymal stem cells or neural stem cells combined with NeuroRegen scaffold transplantation in patients with spinal cord injury.
- Trial name
- NCT02688049
- Testing
- NeuroRegen scaffold/mesenchymal stem cells transplantation, NeuroRegen scaffold/neural stem cells transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese Academy of Sciences