Clinical trials: Spinal Cord Injury
Spinal Cord Injury
Comparison of Lokomat and Aquatic Exercise for Individuals With Chronic Incomplete Spinal Cord Injury
Many people with spinal cord injury (SCI) hold some ability to move their leg muscles, and are therefore considered to demonstrate a motor incomplete injury.
- Trial name
- NCT01407354
- Testing
- Lokomat treadmill training, Aquatic exercise therapy
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Maryland, Baltimore
Spinal Cord Injury
Improving Motor Function After Spinal Cord Injury
The goals of this study are to examine the physiology of Central Nervous System pathways contributing to the control of upper and lower extremity movements after SCI, and to promote the recovery of extremity movements by using…
- Trial name
- NCT01915095
- Testing
- rTMS, Training, Motor Task
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Wheelchair Users
Impact of Pushrim Activated Power Assist Wheelchairs on Mobility Among People With Tetraplegia
The purpose of this three phase study is to evaluate a Pushrim Activated Power Assist Wheelchair (PAPAW). Phase I will examine whether the steady-state, metabolic energy efficiency for propelling a manual wheelchair with and…
- Trial name
- NCT00281463
- Testing
- Pushrim Activated Power Assist
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- VA Pittsburgh Healthcare System
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Spinal Cord Injuries, Deglutition Disorders
Respiratory Capacity and Swallowing Function in Spinal Disorders: A Pilot Study
This study is part of a larger grant, for which the overall goal is to collect measurements of liquid flow through the oropharynx (i.e., mouth and throat) during swallowing.The focus of this study is to evaluate the flow of…
- Trial name
- NCT04114604
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Neuralgia, Spinal Cord Injuries
A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
The purpose of this study is to evaluate if pregabalin relieves nerve pain associated with spinal cord injury compared to placebo (pill that contains no active medicine).
- Trial name
- NCT00407745
- Testing
- pregabalin
- Where
- 67 sites in United States, Chile and 8 more
- Volunteers
- 220 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Neuropathic Back Pain, Spinal Cord Injury
Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury
Back pain is a common secondary condition of both acute and chronic spinal cord injury (SCI). Current existing treatment including both pharmacologic and non-pharmacologic are limited by marginal efficacy or intolerable side…
- Trial name
- NCT02736890
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injury
Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury
We propose to demonstrate that epidural stimulation (ES) can be used to recover significant levels of autonomic control of cardiovascular and respiratory function as well as the ability to voluntarily control leg movements below…
- Trial name
- NCT02037620
- Testing
- 5-6-5 Specify electrode, Restore Advance Pulse Generator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Louisville
Spinal Cord Injuries
Non-invasive Cervical Electrical Stimulation for SCI
Most spinal cord injuries (SCI) are anatomically incomplete - some nerve circuits remain intact, even if the individual cannot feel or control them. Activating spared nerve circuits may improve functional recovery.
- Trial name
- NCT03414424
- Testing
- CES at rest, CES plus active hand or wrist movements
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Spinal Cord Injuries, Neuropathic Pain
Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to pharmacological intervention. Preliminary data suggest brivaracetam is a mechanism-based pharmacological intervention for neuropathic…
- Trial name
- NCT05639946
- Testing
- brivaracetam
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Spinal Cord Injury
Enhancement of Pressure Healing With Pulsatile Lavage
The purpose of this study is to investigate the use of pulsatile lavage to enhance the healing of pressure ulcers in individuals with spinal cord injury (SCI).
- Trial name
- NCT00047619
- Testing
- Pulsatile Lavage
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injuries
Neural Facilitation of Movements in People With SCI
Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery.
- Trial name
- NCT05354206
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Training with some stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lower Urinary Tract Symptoms
Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB
As a collaborative effort between MedStar National Rehabilitation Hospital (NRH)/MedStar Health Research Institute (MHRI), Children's National Medical Center (CNMC) Department of Urology, Children's Research Institute (CRI)…
- Trial name
- NCT02748317
- Testing
- Lactobacillus rhamnosus GG
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- Medstar Health Research Institute
Injuries, Spinal Cord
Clinical Trial to Evaluate One-to-one Peer Mentoring
The research will examine the effects of enhanced peer mentor interactions on facilitating a successful transition to community living following traumatic spinal cord injury (SCI).
- Trial name
- NCT02274649
- Testing
- one-to-one peer mentoring, general peer support
- Volunteers
- 194 people
- Sponsor
- Shepherd Center, Atlanta GA
Spinal Cord Injury
Indego® Exoskeleton; Assessing Mobility for Persons With Spinal Cord Injury (SCI).
This study will evaluate the Indego® device for safety and effectiveness at allowing persons with SCI who are non-ambulatory or poorly ambulatory to stand up and walk under a variety of conditions.
- Trial name
- Indego (NCT02202538)
- Testing
- Indego
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- Parker Hannifin Corporation
Spinal Cord Injuries
Heated Vest for Persons With Spinal Cord Injury
Persons with higher levels of spinal cord injury (above the 2nd thoracic vertebrae; tetraplegia) are unable to maintain normal core body temperature (Tcore) when exposed to cool environments.
- Trial name
- NCT03662308
- Testing
- Heated Vest, Non-Heated Vest
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Pain, Brain Injuries, Traumatic
Telehealth Pain Self-Management for Employed Adults
The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed.
- Conditions
- Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- E-TIPS (NCT04248725)
- Testing
- E-TIPS
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Washington
Spinal Cord Injury, Constipation
Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI
An injury to the spinal cord results in a number of secondary medical problems, including the inability to voluntarily control the bowels.
- Conditions
- Spinal Cord Injury, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT02406859
- Testing
- Bowel Biofeedback, Anorectal Manometry
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Trigeminal Nerve Injuries, Post-herpetic Neuralgia
Transcranial Magnetic Stimulation for Facial Pain
Complex oro-facial pain is a poorly diagnosed and poorly treated cause of significant suffering and disability. This study will explore the ability of fMRI to identify patients with complex oro-facial pain who respond to…
- Conditions
- Trigeminal Nerve Injuries, Post-herpetic Neuralgia, Facial Pain, Nervus Intermedius Neuralgia
- Trial name
- NCT02633306
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota