Clinical trials: Spinal Cord Stimulation
Neuropathic Pain, Multidisciplinary Approach
An Integrated Intervention of Spinal Cord Stimulation and Multidisciplinary Rehabilitation for Chronic Neuropathic Leg Pain: A Single-case Experimental Design Protocol
People with nerve damage can develop nerve pain. The pain can sometimes be severe and unpredictable, causing odd or alarming sensations - for example, lightning-like or electric shock feelings in the area served by the damaged…
- Conditions
- Neuropathic Pain, Multidisciplinary Approach, Rehabilitation Exercise, Acceptance & Commitment Therapy
- Trial name
- SCS-R (NCT07403331)
- Testing
- Treatment bundle
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
Neuromodulation to Overcome Severe Restless Legs Syndrome
This prospective, single-center, first-in-indication feasibility study will evaluate the safety and preliminary effectiveness of spinal cord stimulation (SCS) for the treatment of severe, treatment-refractory primary Restless…
- Trial name
- NO RLS (NCT07780032)
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marshall Holland
Spinal Cord Stimulation
Prospective Evaluation of the Optimal SCS Trial Length
This study aims to determine the ideal length of a spinal cord stimulation (SCS) trial period by analyzing daily pain scores, patient satisfaction, and when patients decide whether to proceed with permanent implantation.
- Trial name
- NCT07709351
- Testing
- Spinal Cord Stimulation (SCS) Trial
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Ohio State University
Back Pain Lower Back Chronic, Spinal Cord Stimulation
EVOKE ECAP-Controlled Lead Placement and Programming in Chronic Pain Patients
This study is designed to evaluate the feasibility of using intra-operative ECAP and Late-Response (LR) recordings for confirmation of activating the neuronal target of the dorsal column in a single-stage SCS lead placement…
- Trial name
- ECAP (NCT05704751)
- Testing
- spinal cord stimulation
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Spinal Cord Stimulation
Does Spinal Cord Stimulation Have an Effect Beyond Patients' Expectations? An Investigation of Treatment and Placebo Effects
The aim of the study is to evaluate treatment outcomes of Spinal Cord Stimulation. In the study each patient participates in four test sessions of 4-5 hours. Patients arrive for test days with their stimulation on.
- Trial name
- NCT07330466
- Testing
- Stimulation ON, Stimulation OFF, Told ON
- Where
- Denmark
- Sponsor
- University of Aarhus
Spinal Cord Stimulation, Electric Stimulation Therapy
Evaluating Safety and Feasibility of Transcutaneous Spinal Cord Stimulation Following Traumatic and Non-Traumatic Spinal Cord Injury: A Pilot Study
The study will be a non-randomized, non-blinded pilot study to analyze the safety and feasibility of a non-significant risk device, transcutaneous spinal cord stimulation.
- Conditions
- Spinal Cord Stimulation, Electric Stimulation Therapy, Traumatic Spinal Cord Injury, Cervical Myelopathy
- Trial name
- STIM (NCT06520020)
- Testing
- Transcutaneous Spinal Cord Stimulation (Tc-SCS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Francis Farhadi
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
The Effect of Spinal Cord Stimulators on Restless Leg Syndrome
This study aims to evaluate neurophysiological responses and symptom changes in individuals with Restless Legs Syndrome (RLS) and/or chronic pain.
- Trial name
- NCT07179406
- Testing
- H-Reflex, Somatosensory evoked potential (SSEP), Vibratory Electrophysiological Response Potential (ERP)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease (PD), Spinal Cord Stimulation (SCS)
Trial of Four Spinal Cord Stimulation Paradigms for Gait Impairment in Parkinson's Disease
Patients with PD and SCS treatment for gait impairment entered a cross-over trial of four stimulation paradigms; high frequency/low pulse width, low frequency/high pulse width, Fast-Acting Sub-perception Therapy, and MicroBurst.
- Trial name
- NCT07659405
- Testing
- Stimulation paradigm: High frequency / low pulse width, Stimulation paradigm: Low frequency / high pulse width, MicroBurst
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- University of Aarhus
Chronic Neuropathic Pain, Chronic Pain Management
Exploring Neurosphere's Remote Monitoring and Virtual Clinic Features in Improve Quality of Life and Reduce Costs
This study evaluates the effectiveness of Abbott's Proclaim™ and Eterna™ Spinal Cord Stimulator (SCS) systems, along with the Neurosphere™ virtual clinic platform, in managing chronic pain.
- Conditions
- Chronic Neuropathic Pain, Chronic Pain Management, Spinal Cord Stimulation (SCS), Pain Modulation
- Trial name
- TRC-AB-1 (NCT06647576)
- Testing
- Spinal Cord Stimulation - In Clinic, Spinal Cord Stimulation - Neurosphere
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mahesh Pattabiraman
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Parkinson's Disease (PD), Gait Disorders
Effects of the Stimulation Site of tsMS With TMS on Functional Mobility in Individuals With Parkinson's Disease
This randomized clinical trial aims to compare the effects of two different trans-spinal magnetic stimulation (tsMS) application sites, cervical versus thoracic, when combined with repetitive transcranial magnetic stimulation…
- Conditions
- Parkinson's Disease (PD), Gait Disorders, Transcranial Magnetic Stimulation, Spinal Cord Stimulation
- Trial name
- NCT07488026
- Testing
- Repetitive Transcranial Magnetic Stimulation, Cervical Trans-spinal Magnetic Stimulation, Thoracic Trans-spinal Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Pernambuco
Spinal Cord Injuries, Spinal Cord Stimulation
Spinal Cord Stimulation and Respiration After Injury
Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this NIH-funded study is to develop a rehabilitation strategy for respiration in…
- Conditions
- Spinal Cord Injuries, Spinal Cord Stimulation, Breathing Exercises, Rehabilitation
- Trial name
- NCT05178056
- Testing
- Spinal Cord Epidural Stimulation, Respiratory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation
Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation
This study is being conducted in patients who will receive a spinal cord stimulator. This device helps manage chronic neuropathic pain in the trunk and/or limbs.
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- NCT07413731
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Brai²n
Spinal Cord Injuries, Non Invasive Spinal Stimulation
Development of a Novel Strategy to Analyze the Effect on Gait Using Transcutaneous Spinal Current Stimulation in Incomplete Spinal Cord Injured Patients
To determine whether the combination of non-invasive spinal cord stimulation together with gait rehabilitation reduces spasticity and facilitates recovery of lower limb motor strength and gait function in patients with incomplete…
- Conditions
- Spinal Cord Injuries, Non Invasive Spinal Stimulation, Gait Disorders, Neurologic, Motor Function; Retardation
- Trial name
- NCT07289191
- Testing
- transcutaneous spinal cord stimulation
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut Guttmann
Parkinson Disease, Freezing of Gait
Application of Thoracic Epidural SCS for Managing FOG in Patients With Advanced Parkinson's Disease
Spinal cord stimulation (SCS) has proven to be effective for pain that is unresponsive to medication. This technique involves an anesthesiologist or a neurosurgeon placing stimulation electrodes at the thoracic vertebrae to…
- Conditions
- Parkinson Disease, Freezing of Gait, Spinal Cord Stimulation
- Trial name
- NCT06630702
- Testing
- SCS electrode stimulation 1, SCS electrode stimulation 2, SCS electrode stimulation 3
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Peripheral Arterial Disease, Painful Diabetic Neuropathy
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition.
- Conditions
- Peripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic Pain
- Trial name
- NCT06480786
- Testing
- Spinal cord stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Nebraska
Failed Back Surgery Syndrome, Spinal Cord Stimulation
Return to Work for Persistent Spinal Pain Syndrome Type II Patients
A multicenter randomized controlled trial will be conducted to evaluate whether the ability to work in Persistent Spinal Pain Syndrome Type II (PSPS-T2) patients after SCS implantation is different after a personalized…
- Trial name
- OPERA (NCT05269212)
- Testing
- Usual Care trajectory, A biopsychosocial rehabilitation program
- Where
- 5 sites in Belgium
- Volunteers
- 112 people
- Sponsor
- Moens Maarten
Neuropathic Pain, Chronic Pain
Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)
This project aims to identify key cells and molecules involved in the development and modulation of neuropathic pain treated with spinal cord stimulation (SCS).
- Conditions
- Neuropathic Pain, Chronic Pain, Spinal Cord Stimulation (SCS)
- Trial name
- NCT07153211
- Testing
- Immunological Factors
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Pawel Sokal
Spinal Cord Injury, Spinal Cord Injury Thoracic
Investigating the Impact of Spinal Cord Electrical Stimulation Combined With Individualized Physical Therapy on Lower Extremity Function in Patients With Spinal Cord Injury
This study aims to understand the differences in the effects of two rehabilitation approaches on lower limb function recovery in patients with spinal cord injuries: 1.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Thoracic, Spinal Cord Injury/Damage, Spinal Cord Injury T1-L2
- Trial name
- NCT07037628
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Lian-Cing Yan, MSPT