Clinical trials: Spinal Cord Tumor
Spinal Metastases, Spinal Tumor
The Effect of Radiotherapy After Separation Surgery for Spinal Metastases
The aim of this clinical study is to explore the impact of whether radiotherapy is administered after spinal metastasis surgery on the prognosis and survival of patients, to describe the clinical outcomes, and to optimize future…
- Conditions
- Spinal Metastases, Spinal Tumor, Radiotherapy, Separation Surgery
- Trial name
- NCT07527884
- Testing
- radiotherapy
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Wei Xu
Hemangioblastoma, Hippel Lindau Disease
Study of Brain and Spinal Cord Tumor Growth and Cyst Development in Patients With Von Hippel Lindau Disease
The purpose of this study is to learn more about the growth of brain and spinal cord tumors and cysts that develop in association with them in patients with von Hippel-Lindau disease.
- Trial name
- NCT00005902
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neurofibromatosis Type 1, Plexiform Neurofibroma
AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine
This phase II trial is studying how well AZD2171 works in treating patients with neurofibromatosis type 1 and plexiform neurofibroma and/or neurofibroma near the spine.
- Conditions
- Neurofibromatosis Type 1, Plexiform Neurofibroma, Spinal Cord Neurofibroma
- Trial name
- NCT00326872
- Testing
- Cediranib Maleate
- Where
- 9 sites in United States
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Disease, Spinal Cord Injury
Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.
- Conditions
- Metastatic Disease, Spinal Cord Injury, Spinal Degeneration, Spinal Deformity
- Trial name
- NCT03632005
- Testing
- Vacuum Assisted Closure, Sterile dressing
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- John Street
Metastatic Epidural Spinal Cord Compression
Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression
The aim of this trial is to evaluate the differences in pain relief, neurological function, quality of life and survival in patients with metastatic epidural spinal cord compression (MESCC) who are managed with a combination of…
- Trial name
- MESCC (NCT00634426)
- Testing
- Surgical excision of the metastatic process, Radiotherapy of the metastatic spine process
- Where
- 10 sites in United States, Canada
- Volunteers
- 163 people
- Sponsor
- AOSpine North America Research Network
Central Nervous System Tumor
Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System
The purpose of this study is to examine the use of a single dose of tozuleristide (24 or 36 mg) and the Canvas imaging system during surgical resection of primary central nervous system (CNS) tumors: Primary gadolinium enhancing…
- Trial name
- NCT04743310
- Testing
- tozuleristide, Canvas imaging system, Surgical resection of tumor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Yu
Spinal Tumors, Surgical Treatment
Swiss Spinal Tumor Registry (Swiss-STR)
The Swiss Spinal Tumor Registry is a prospective REDCap-based registry, collecting data of surgically treated patients with primary and metastatic tumors of the spine.
- Trial name
- SSTR (NCT06869746)
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Luzerner Kantonsspital
Spinal Diseases, Spinal Metastases
Intra-arterial Chemotherapy for Spinal Metastases
Metastatic malignant tumors comprise the vast majority of spinal tumors in adults. The most devastating complication of spinal metastatic disease (SMD) is invasion of the spinal canal and compression of the spinal cord or the…
- Conditions
- Spinal Diseases, Spinal Metastases, Spinal Tumors
- Trial name
- SIAC (NCT01637766)
- Testing
- Melphalan (intra-arterial infusion)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Spinal Cord Tumor
Development of the MDASI-Spine Tumor Module
The goal of this research study is to learn the severity of certain symptoms in patients with tumors of the spine or spinal cord. Researchers also want to learn if the M. D.
- Trial name
- NCT00430872
- Testing
- Survey
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- M.D. Anderson Cancer Center
Glioma, Glioma of Brain
Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently
Functional magnetic resonance imaging (fMRI) is a non-invasive test used to detect changes in brain activity by taking picture of changes in blood flow. The imaging helps doctors better understand how the brain works.
- Conditions
- Glioma, Glioma of Brain, Glioma of Spinal Cord
- Trial name
- NCT03496181
- Testing
- Multilingual Aphasia Examination, Language paradigms + RS fMRI, Language paradigms + RS fMRI + one anatomical sequence
- Where
- 3 sites in United States, Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neoplasm Metastasis, Spinal Cord Diseases
Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases
The purpose of this research is to combine two complementary modes of treatment, spinal interstitial laser ablation and stereotactic spine radiosurgery (SSRS) for the treatment for spinal tumors near the spinal cord with an…
- Conditions
- Neoplasm Metastasis, Spinal Cord Diseases, Spinal Cord Compression, Spinal Cord Tumor
- Trial name
- NCT05023772
- Testing
- Stereotactic Laser Ablation, Stereotactic Radiosurgery, MRI guided laser ablation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Henry Ford Health System
Brain and Central Nervous System Tumors, Metastatic Cancer
Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00541138
- Testing
- carboplatin, tamoxifen citrate, topotecan hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- City of Hope Medical Center
Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor
Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma
This phase I trial is studying the side effects and best dose of ispinesib in treating young patients with relapsed or refractory solid tumors or lymphoma.
- Conditions
- Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma
- Trial name
- NCT00363272
- Testing
- ispinesib, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Triple-negative Breast Cancer, NSCLC, Squamous or Non-Squamous
AN0025 and Pembrolizumab Combination in Advanced Solid Tumors
This is an open-label, multicenter, phase Ib study to evaluate the safety and preliminary efficacy of AN0025 in combination with pembrolizumab in patients with locally advanced/metastatic tumors.
- Conditions
- Triple-negative Breast Cancer, NSCLC, Squamous or Non-Squamous, Urothelial Carcinoma of the Bladder, Microsatellite Stable (MSS) Colorectal Cancer (CRC)
- Trial name
- NCT04432857
- Testing
- AN0025, Pembrolizumab
- Where
- 6 sites in United States, France
- Volunteers
- 63 people
- Sponsor
- Adlai Nortye Biopharma Co., Ltd.
Salivary Gland Cancer
Androgen Deprivation Therapy in Advanced Salivary Gland Cancer
Salivary Gland (SG) Cancers are a rare and heterogeneous group of tumors, usually approached by multidisciplinary teams in high specialized centers. Until today no standard of care exists to treat these cancers.
- Trial name
- NCT01969578
- Testing
- bicalutamide + triptorelin, Cisplatin + Doxorubicin, Carboplatin + Paclitaxel
- Where
- 26 sites in Austria, Belgium and 6 more
- Volunteers
- 149 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Stereotactic Radiosurgery, Spinal Tumor
Stereotactic Radiosurgery Prognosis Assessment for Spinal Tumors Based on Radiomics
This study aims to assess multimodal Radiomics-based prediction model for prognostic prediction in spinal tumors.
- Conditions
- Stereotactic Radiosurgery, Spinal Tumor, Radiomics, Prognosis
- Trial name
- NCT05369689
- Testing
- No interventions
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhuang Hongqing
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Adult Spinal Cord Neoplasm, Spinal Bone Metastases
Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
This pilot clinical trial studies beta-tricalcium phosphate bone graft in treating patients undergoing surgery for metastatic spine cancer.
- Conditions
- Adult Spinal Cord Neoplasm, Spinal Bone Metastases, Spinal Cord Compression
- Trial name
- NCT01407341
- Testing
- musculoskeletal complications management/prevention, bone graft, quality-of-life assessment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Southern California
Spinal Tumor, Spinal Hemangioma
The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma
Spinal hemangioma is one of the most common benign vertebral tumours. Being mostly asymptomatic, it is still associated with a pain syndrome especially if encroaches into the neural canal.
- Conditions
- Spinal Tumor, Spinal Hemangioma, Beta Blocker Toxicity
- Trial name
- NCT05106179
- Testing
- Atenolol Pill, Propranolol Pill
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Center for Vascular Pathology, Moscow
Spinal Cord Metastasis, Spinal Cord Tumor Malignant Intramedullary
Microsurgical Resection of Intramedullary Spinal Cord Metastases
The aim of the study is to establish a multi-center, retrospective database for patients with intramedullary spinal cord metastases (ISCM) and analyse the functional outcome in surgically treated ISCM patients.
- Conditions
- Spinal Cord Metastasis, Spinal Cord Tumor Malignant Intramedullary, Functional Outcome, Radiotherapy; Complications
- Trial name
- NCT06042946
- Testing
- Microsurgical resection of ISCM
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Cantonal Hospital of St. Gallen