Clinical trials: Spinal Decompression
Pain, Disability
Additional Effects of Pain Neuroscience Education With Standard Pre-operative Physiotherapy on Post-laminectomy Pain and Disability.
This randomized controlled trial investigates whether adding Pain Neuroscience Education (PNE) to standard pre-operative physiotherapy improves outcomes after lumbar laminectomy.
- Conditions
- Pain, Disability, Laminectomy, Physical Therapy
- Trial name
- NCT07801586
- Testing
- Experimental Group - Pain Neuroscience Education + Standard Pre-operative Protocol, Control Group - Standard Pre-Operative Care
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Foundation University Islamabad
Postoperative Pain
Use of IV Acetaminophen in the Treatment of Post Operative Pain in Patients Undergoing Craniotomy and Spine Surgery
The purpose of this study is to investigate the effectiveness of intravenous acetaminophen (Tylenol) for post operative pain control in patients undergoing craniotomies (brain surgery) and spine surgery.
- Trial name
- NCT03261310
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Chiari Malformation Type I, Tonsillectomy
PFDD Versus PFDRT in Chiari Decompression Surgery
The purpose of this study is to determine whether a posterior fossa decompression and duraplasty with or without tonsil manipulation results in better patient outcomes with fewer complications and improved quality of life in…
- Trial name
- NCT06079125
- Testing
- Posterior fossa decompression with duraplasty, PFDD with tonsillar resection/reduction
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xuanwu Hospital, Beijing
Spinal Cord Injuries
Early Surgical Intervention Combined With Weight-supported Walking Training
To determine the efficacy of a novel combinatorial treatment involving early surgical intervention and long-term weight-bearing walking training in spinal cord injury (SCI) patients clinically diagnosed as complete or American…
- Trial name
- NCT04034108
- Testing
- Surgical intervention combined with weight-supported ambulation training
- Where
- 2 sites in China
- Volunteers
- 339 people
- Sponsor
- Kunming Tongren Hospital
Thyroid Associated Orbitopathy
Changes in Orbital Macrovascular and Intraocular Microvascular Blood Flow After Orbital Decompression Surgery in Patients With Thyroid Eye Disease
This study aims to evaluate the effects of balanced orbital decompression surgery in patients with inactive thyroid-associated orbitopathy.
- Trial name
- BOD-VASC (NCT07393230)
- Testing
- Balanced Orbital Decompression Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Postoperative Pain
Fentanyl 12 Mcg Transdermal Patch For Postoperative Pain
The investigators designed a prospective randomized study to investigate the effect of fentanyl 12 mcg transdermal patch on postoperative pain following unilateral, single-level laminectomy/discectomy.
- Trial name
- NCT03199157
- Testing
- Fentanyl transdermal patch
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Baskent University
Ossification of the Posterior Longitudinal Ligament
A Prospective Study Comparing the Efficacy of Laminoplasty and Laminectomy With Fusion for Ossification of the Posterior Longitudinal Ligament With High Occupation Rate in Cervical Spine
The efficacy of laminoplasty and laminectomy with fusion for ossification of the posterior longitudinal ligament with high occupation rate in the cervical spine is not clear in the literature report so far.
- Trial name
- NCT05019001
- Testing
- Laminoplasty, Laminectomy With Fusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Spinal Stenosis Cervical
Multicentric Case Series of Uniportal Endoscopic Posterior Cervical Decompression for Cervical Spinal Stenosis
Cervical spinal stenosis is a condition that can cause pain, sensory disturbances, and motor deficits due to the compression of neural structures in the cervical spine.
- Trial name
- DEC-SCM (NCT06886802)
- Testing
- Posterior Uniportal Endoscopic Cervical Decompression
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- TecSalud Investigación Clínica
Single Level Spinal Fusion, Discetomy
Integration of Mindfulness and Acupuncture After Spine Surgery
The Integration of Mindfulness and Acupuncture for individuals undergoing Spine Surgery (I-MASS) is a novel combination of integrative treatments to improve post-surgical recovery.
- Conditions
- Single Level Spinal Fusion, Discetomy, Laminectomy
- Trial name
- I-MASS (NCT06429072)
- Testing
- Mindfulness training, Acupuncture, Enhanced education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Lumbar Spinal Stenosis
Long-Term Outcomes for Lumbar Spinal Stenosis Patients Treated With X STOP®
The Long-Term Outcomes Study (LTOS) is a multi-center longitudinal cohort study of all patients who received the X-STOP device in the Pivotal Trial, Continued Access Protocol (CAP), or Cross-over Study (COS).
- Trial name
- NCT00534092
- Testing
- X STOP® Interspinous Process Decompression System
- Where
- 5 sites in United States
- Volunteers
- 69 people
- Sponsor
- Medtronic Spine LLC
Posterior Cervical Surgery, Posterior Cervical Fusion
Clavicle Splint for Pain Reduction After Posterior Cervicothoracic Surgery
The purpose of the study is to see whether a clavicle splint can decrease the pain after posterior cervicothoracic surgery. The term "cervicle splint" conveys that the investigators do not deal with clavicle fractures here but…
- Conditions
- Posterior Cervical Surgery, Posterior Cervical Fusion, Posterior Cervical Laminectomy, Posterior Cervical Laminoplasty
- Trial name
- NCT01977690
- Testing
- Clavicle Brace
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Postoperative Pain, Lumbar Laminectomy
Thoracolumbar Interfascial Plane Block Versus Bilateral Erector Spinae Plane Block In Lumbar Laminectomy
The aim of this prospective randomized trial is to compare the efficacy ultrasound guided thoracolumbar interfascial plane block versus bilateral ultrasound guided erector spinae plane block for post-operative pain management…
- Conditions
- Postoperative Pain, Lumbar Laminectomy, Thoracolumbar Interfascial Plane Block, Erector Spinae Plane Block
- Trial name
- NCT04757480
- Testing
- Thoracolumbar Interfascial Plane Block (TLIP), Bilateral Erector Spinae plane Block (ESB)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Lumbar Spinal Stenosis
Condition of Approval Study
This prospective, multicenter longitudinal five-year study of X-STOP PEEK usage in LSS patients is designed to supplement pre-market safety and effectiveness data with information on longer-term device performance in a population…
- Trial name
- COAST (NCT00517751)
- Testing
- X-STOP PEEK
- Where
- 23 sites in United States
- Volunteers
- 176 people
- Sponsor
- Medtronic Spine LLC
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Pain and Anxiety in Patients Undergoing Surgery for Lumbar Laminectomy.
Perioperative Melatonin in Lumbar Laminectomy
Patients undergoing lumbar laminectomy surgery will receive either 5 or 10 mg melatonin or placebo once the evening before surgery and again 90 minutes before surgery.
- Trial name
- NCT01126294
- Testing
- 5 mg melatonin, 10 mg melatonin
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University Health Network, Toronto
Lumbar Laminectomy
A Study of Epidural Bupivacain-soaked Absorbable Gelatin Sponge on Post-operative Pain in Lumbar Laminectomy
The effective relief of pain is of paramount importance to anyone treating patients undergoing surgery. Post-operative pain increases the possibility of post-surgical complications, raises the cost of medical care, and most…
- Trial name
- NCT01847339
- Testing
- bupivacaine, saline solution
- Where
- United States
- Sponsor
- The Cleveland Clinic
Hemifacial Spasm, Microvascular Decompression
Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery
There have been reports of monitoring LSR during MVD surgery helps predicting the clinical outcome of MVD.However, there have been no evidence of which degree of partial neuromuscular blockade should be performed or no…
- Conditions
- Hemifacial Spasm, Microvascular Decompression, Lateral Spread Response Monitoring
- Trial name
- NCT01598961
- Testing
- TOF count-guided partial NMB, T1/Tc guided partial NMB, No NMB
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Surgical Site Infection, Antibiotics Prophylaxis
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay.
- Trial name
- NCT05398081
- Testing
- Cefuroxime (Zinnat®), Ceftriaxone (Rocephin®)
- Where
- Nigeria
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr. Promise Tamunoipiriala Jaja
Spinal Stenosis, Spondylolisthesis
Decompression vs. Fusion for Stable Degenerative Spondylolisthesis
The purpose of this study is to assess the feasibility of a full-scale multicenter randomized, controlled trial comparing the effectiveness of two surgical treatments for a condition associated with lumbar spinal stenosis called…
- Trial name
- NCT02348645
- Testing
- Spinal fusion, Spinal decompression
- Where
- 8 sites in Canada
- Volunteers
- 70 people
- Sponsor
- University Health Network, Toronto
Lumbar Spinal Stenosis
Comparision of Endoscopic Discectomy and Microdiscectomy for the Treatment of Lumbar Spinal Stenosis
The purpose of this study is to conduct a multicenter comparison of the clinical efficacy of Endo-Surgi Plus endoscopic technique, UBE endoscopic technique, and microdiscectomy technique in the treatment of lumbar spinal…
- Trial name
- NCT06719037
- Testing
- Endo-Surgi Plus endoscopic surgery, Unilateral biportal endoscopic surgery, Microdiscectomy
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Qilu Hospital of Shandong University