Clinical trials: Spinal Disorder
Poliomyelitis
Immunogenicity of Intramuscular and Intradermal IPV
This is an open-label phase IV randomized clinical trial that will compare immune responses among infants who receive different dose schedules of either fractional dose or full dose inactivated poliovirus vaccine (IPV), delivered…
- Trial name
- IM and ID IPV (NCT04063150)
- Testing
- fIPV (0.1 mL) ID, fIPV (0.1mL) IM, fIPV (0.2mL) IM
- Where
- Bangladesh
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Preeclampsia, Hypotension
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Hypotension remains a common clinical problem after induction of spinal anesthesia for cesarean delivery. Maternal hypotension has been associated with considerable morbidity (maternal nausea and vomiting and fetal/neonatal…
- Trial name
- NCT00458003
- Testing
- Ephedrine, Phenylephrine
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Psoriatic Arthritis, Arthritis
99mTc-anti-TNF-alpha Scintigraphy in the Evaluation of Inflammatory Processes Activity
Rheumatoid and psoriatic arthritis patients benefit from anti-TNF-α therapy, once it is effective in reducing joint and skin manifestations in 60-70% of patients with inflammatory articular joint and skin diseases.
- Trial name
- NCT02134613
- Testing
- 99mTc-anti-TNF-alpha Scintigraphy
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Diphtheria, Tetanus
Antibody Persistence at Age 3.5 and 4.5 Years After Primary and Booster DTaP-IPV-Hep B-PRP~T or Infanrix Hexa Vaccination
This is a follow-up of the primary series vaccination schedule in Study A3L24 (NCT01177722) and booster vaccination in Study A3L27 (NCT01444781).
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01983540
- Testing
- DTaP-IPV-Hep B- PRP~T + Prevenar + Rotarix vaccine, DTaP- IPV-Hep B-PRP~T + Prevenar + Rotarix + Infanrix hexa vaccine, Infanrix hexa + Prevenar + Rotarix vaccine
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 558 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Poliomyelitis
A Study to Evaluate Safety and Immunogenicity of Sequential Vaccination of Sabin Inactivated Poliomyelitis Vaccine (Vero Cell) and Live Attenuated Poliomyelitis Vaccine in Healthy 2-month-old Infants
The goal of this clinical trial is to evaluate the immunogenicity and safety of a Sabin Inactivated Poliomyelitis Vaccine (sIPV) and a commercially available Live Attenuated Poliomyelitis Vaccine (bOPV) according to the "2+1…
- Trial name
- NCT06752174
- Testing
- sIPV+bOPV, wIPV+bOPV
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Minhai Biotechnology Co., Ltd
Double Level Lumbar Spondylolisthesis (L3-L5), Posterior Lumbar Interbody Fusion (PLIF)
Effect of Addition of Dexmedetomidine During Ultrasound Guided Bilateral Single Shot Erector Spinae Plane Block in Patients Undergoing Posterior Lumbar Interbody Fusion Under General Anesthesia
Posterior lumbar interbody fusion (PLIF) is the management of choice in double level lumbar (L) spondylolisthesis (L3-L5) after ineffective conservative treatment.
- Conditions
- Double Level Lumbar Spondylolisthesis (L3-L5), Posterior Lumbar Interbody Fusion (PLIF), Lumbar Fixation Surgery
- Trial name
- NCT03746418
- Testing
- Ultrasound Guided Bilateral single shot Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Compression of Spinal Nerve Root, Spinal Disorder
Soleus H-Reflex in Different Sitting Postures
The purpose of this study was to examine the effect of prolonged sitting duration and three different sitting postures (erect, slumped, and slouched sitting postures) on spinal nerve root function by measuring the soleus (SOL)…
- Conditions
- Compression of Spinal Nerve Root, Spinal Disorder, Low Back Pain
- Trial name
- NCT01744899
- Testing
- Sitting posture
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Skin Physiology, Spinal Cord Injuries
Intelligent Underwear (IU) in Paraplegics
Pressure injuries are a major problem in patients with no or limited mobility and sensation such as paraplegics. Changes in skin physiology like changes in skin perfusion, oxygenation and humidity may explain and help to detect…
- Conditions
- Skin Physiology, Spinal Cord Injuries, Pressure Injury
- Trial name
- ProTex (NCT04008160)
- Testing
- ProTex
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Diphtheria, Tetanus
Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines
The present clinical study will assess the immunogenicity and reactogenicity of the subsequent administration of Aventis Pasteur's DTacP-IPV//PRP~T combined vaccine (PENTAVAC™/PENTAXIM), as a three-dose primary vaccination in 6…
- Conditions
- Diphtheria, Tetanus, Polio, Pertussis
- Trial name
- NCT00254917
- Testing
- Diphteria, Tetanus, Polio, Acellular Pertussis, Hib vaccine
- Where
- Philippines
- Volunteers
- 387 people, healthy volunteers welcome
- Sponsor
- Sanofi
Scoliosis
The Idiopathic Scoliosis and Its Treatment (Orthopaedic and Surgery): Effect of the Severity, the Orthosis and the Arthrodesis on the Gait
The purposes of this study were as follows: 1) to compare locomotion parameters (kinematic, EMG, mechanical work and energy cost changes during walking in able-bodied subjects and AIS patients,2) to evaluate the effects of the…
- Trial name
- scoliosis (NCT00842218)
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Haemophilus Infections, Diphtheria
Surveillance Program to Determine Product Specific Rates of Invasive Hib Disease
To monitor the occurrence of invasive Hib disease over time and to determine product-specific rates of invasive Hib disease within the monitored population.
- Conditions
- Haemophilus Infections, Diphtheria, Tetanus, Polio
- Trial name
- NCT00855855
- Testing
- DTaP-IPV/Hib
- Where
- 59 sites in United States
- Volunteers
- 20,830 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Degeneration, Spondylosis
Prospective Clinical Evaluation of the New Aegis Plate for Anterior Interbody Fusions
Introduction: Degenerative changes of the discs and facet joints in the lumbar spine can result in pain and disability from spondylosis, spondylolisthesis and stenosis.
- Conditions
- Degeneration, Spondylosis, Spondylolithesis, Stenosis
- Trial name
- Aegis (NCT00555659)
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Columbia Orthopaedic Group, LLP
SCI - Spinal Cord Injury
Effect of tSCS on Ankle Movement Training in Individuals With SCI
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI).
- Trial name
- NCT06596174
- Testing
- Transcutaneous spinal cord stimulation (tSCS), Short-term Machine-Assisted Ankle Movement Training with tSCS, Long-term Effects of Machine-Assisted Ankle Movement Training with tSCS
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Scoliosis Idiopathic
The Effect of Asymmetric Spinal Stabilization Exercise on Scoliosis
The purpose of this study is to evaluate the effect of asymmetric spinal stabilization exercise on scoliosis
- Trial name
- NCT03497520
- Testing
- asymmetric spinal stabilization exercise
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Spinal Cord Injuries, Incomplete Spinal Cord Injury
A Novel System for Quasi Real-Time Tracking of Neuromuscular Responses During NMES
Neuromuscular electrical stimulation (NMES) remains as one of the effective rehabilitation modalities for addressing recovery of neuromuscular function after a spinal cord injury (SCI).
- Trial name
- NCT05243576
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Disc Degeneration
Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease
This study seeks to bridge these technologies and obtain data regarding the safety and efficacy of image guided percutaneous needle injection of expanded autologous bone marrow derived mesenchymal stem cells to symptomatic…
- Trial name
- NCT03692221
- Testing
- MSC Treatment group 1 (low dose), MSC Treatment group 2 (high dose), Healthy Control (no treatment)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Spinal Cord Injuries, Shoulder Impingement Syndrome
Freehand Ultrasound to Evaluate Scapular Kinematics in People With Paraplegia
Shoulder pain is very common in people with spinal cord injury (SCI). Persons with high-level paraplegia have higher chances to suffer shoulder pain and injury than those with lower-level paraplegia due to the shoulder muscle…
- Trial name
- FUS (NCT02357914)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Spinal Cord Injuries
The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments.
The aim of the study is to investigate the effectiveness of a new rehabilitation technology for paralysis that occurs after stroke or spinal cord injury.
- Trial name
- NCT05115149
- Testing
- VIBRAINT RehUp robotic orthosis, tSCS during the exercise, tSCS prior to the exercise
- Where
- 6 sites in Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Anesthesia, Adverse Effect
Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia
The purpose of the study is to determine the more effective intravenous bolus of norepinephrine for maintaining blood pressure during a spinal anesthesia for a cesarean delivery with the fewer side effects.
- Conditions
- Anesthesia, Adverse Effect, Hypotension, Cesarean Section Complications
- Trial name
- NCT03706755
- Testing
- Norepinephrine: 1mcg/kg, Norepinephrine 0,5mcg/kg
- Where
- Tunisia
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
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