Clinical trials: Spinal Disorders/Injuries, open to volunteers
Osteoporosis Fracture, Osteoporosis Vertebral
Development and Validation of a Postoperative Re-fracture Risk Model for Osteoporotic Spinal Fractures
In this project, IDEAL-IQ technology and PDFF and R2* image-based imaging methods are used to analyze the intrinsic relationship between preoperative vertebral bone marrow fat content, magnetic susceptibility properties of bone…
- Conditions
- Osteoporosis Fracture, Osteoporosis Vertebral, Compression Fracture, Perform PVP / PKP Treatment
- Trial name
- NCT06379243
- Testing
- PVP/PKP
- Where
- China
- Volunteers
- 560 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
Spinal Cord Injury
The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury
The goal of this clinical trial is to evaluate the effect of probiotic and prebiotic supplementation in individuals with chronic spinal cord injury experiencing gastrointestinal complaints.
- Trial name
- PRO-GIDSCI (NCT06870331)
- Testing
- Probiotic, Prebiotic
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Osteo Arthritis Shoulders, Osteonecrosis
Exactech Shoulder Post Market Clinical Follow-up Study
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time.
- Conditions
- Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
- Trial name
- NCT05603728
- Where
- 40 sites in United States, Canada and 4 more
- Volunteers
- 20,000 people
- Sponsor
- Exactech
Neurological Disorders, Wheelchair Mobility
Evaluation of the Wheelchair School (Drivkraft) a Clinical Study
This project will evaluate the Wheelchair School with the Drivkraft Methodology in a clinical setting. Participants are adults with chronic neurological diagnoses.
- Conditions
- Neurological Disorders, Wheelchair Mobility, Rehabilitation
- Trial name
- NCT07131553
- Testing
- Wheelchair school, Comparison group, conventional rehabilitation
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Tetraplegia/Tetraparesis, Quadriplegia
VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration
The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- NCT07224256
- Testing
- N1 Implant, R1 Robot
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Neuralink Corp
Metastatic Epidural Spinal Cord Compression, Spinal Cord Compression
Miami "RADAR" Trial
The purpose of this study is to see if treating cancer with radiation therapy administered by the Varian Ethos system can control patient's tumor and eliminate the need for surgery used to treat nerves in the spine flattened by…
- Trial name
- RADAR (NCT06077071)
- Testing
- Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Neuropathic Pain
Virtual Walking and Neuromulation to Reduce Neuropathic Pain After a Spinal Cord Injury
The goal of this single-subject design is to evaluate an intervention combining neuromodulation, virtual reality, and muscle vibration to reduce neuropathic pain in individuals following a spinal cord injury.
- Trial name
- NCT07254767
- Testing
- Transcranial Direct Current Stimulation (tDCS) combined with virtual reality and muscle vibration
- Volunteers
- 10 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Spinal Cord Injuries, Neuropathic Pain
Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Neurological Injury, Pain
- Trial name
- NCT05492188
- Testing
- Operant Conditioning of Cutaneous Reflexes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injuries, Neuropathic Pain
Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain
The purpose of this study is to investigate the effectiveness of bodily illusions combined with transcranial direct current stimulation (tDCS) on neuropathic pain symptoms and sensory functions in participants with spinal cord…
- Trial name
- NCT06010251
- Testing
- tDCS and bodily illusions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis
Spinal Cord Associative Plasticity Study
Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis, Cervical Myelopathy
- Trial name
- SCAP (NCT05163639)
- Testing
- Non-invasive pairing of cortical and spinal stimulation, Intraoperative pairing of cortical and spinal stimulation, Non-invasive repeated pairing of cortical and spinal stimulation (SCAP)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D)
Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia
This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history.
- Conditions
- Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D), Cardiac Remodeling
- Trial name
- HEART_REMOD_AD (NCT07456722)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Cerebrovascular Accident, Post-polio Syndrome
Nomad P-KAFO Study
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk.
- Conditions
- Cerebrovascular Accident, Post-polio Syndrome, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- NCT05644522
- Testing
- Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Upper Limb Spinal Cord Stimulation for Rehabilitation Enhancement
In the United Kingdom, there are more than 1000 new cases of spinal cord injury (SCI) each year, with around half of these injuries affecting the cervical spine.
- Trial name
- Up-Stim (NCT05991804)
- Testing
- Transcutaneous spinal cord stimulation added to inpatient rehabilitation
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University College, London
Lumbar Spinal Stenosis, Carpal Tunnel Syndrome (CTS)
124I-Evuzamitide PET/CT Imaging In Patients With Lumbar Spinal Stenosis and Carpal Tunnel Syndrome
This clinical trial will use the amyloid-binding radiotracer, 124I-evuzamitide, to potentially detect amyloid, in the heart and elsewhere, in patients who have a history of lumbar spinal stenosis and/or carpal tunnel syndrome.
- Conditions
- Lumbar Spinal Stenosis, Carpal Tunnel Syndrome (CTS), Cardiac Amyloidosis
- Trial name
- NCT06907849
- Testing
- 124I-evuzamitide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Phantom Limb Pain
Study of Phantom Limb Pain Suppression Using Neuromodulation Methods
This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral…
- Trial name
- NCT06644807
- Testing
- Motor Cortex Stimulation, Spinal cord stimulation, Peripheral Nerve Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Spinal Cord Injury
Auricular Acupressure and Limb Massage for Neuropathic Pain in Spinal Cord Injury
This randomized controlled trial included 90 patients with spinal cord injury, divided into an experimental group and a control group (45 each).
- Trial name
- NCT06700278
- Testing
- auricular acupressure, body acupoint massage
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Neurogenic Detrusor Overactivity
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
- Trial name
- KANGUROO (NCT05491525)
- Testing
- Vibegron
- Where
- 38 sites in United States, Belgium and 14 more
- Volunteers
- 71 people
- Sponsor
- Urovant Sciences GmbH
Spinal Cord Injury, Chronic Spinal Cord Injury
First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury
This study aim to investigate the safety and exploratory efficacy of STUP-001 which is AAV-based spinal cord injury investigational product.
- Trial name
- STUP-001 (NCT06922890)
- Testing
- STUP-001
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Yonsei University
Stroke, Gait Disorders, Neurologic
ZEPU AI9 Exoskeleton Rehabilitation Robot
The goal of this clinical trial is to learn whether the ZEPU AI9 lower limb exoskeleton robot is feasible, safe, and effective for people with walking difficulty caused by stroke, incomplete spinal cord injury, or orthopedic…
- Conditions
- Stroke, Gait Disorders, Neurologic, Spinal Cord Injuries, Incomplete, Postoperative Complication
- Trial name
- NCT07750808
- Testing
- ZEPU-AI9 Lower Limb Exoskeleton Gait Training, Standard-of-Care Rehabilitation
- Where
- Bangladesh
- Volunteers
- 36 people
- Sponsor
- Bangladesh Medical University
Osteoarthritis, Tendinitis
Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions
The aim of the study is to determine the efficacy of an Amniotic Fluid Tissue Product for pain relief and functional improvements for all types of musculoskeletal conditions.
- Conditions
- Osteoarthritis, Tendinitis, Sports Injury, Degenerative Disc Disease
- Trial name
- NCT03390920
- Testing
- Umbilical Allograft
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- R3 Stem Cell